PRAX vs. SMH

Last updated Apr 2, 2026

Compare and contrast key facts about Praxis Precision Medicines, Inc. (PRAX) and VanEck Semiconductor ETF (SMH).

SMH is a passively managed fund by VanEck that tracks the performance of the MVIS US Listed Semiconductor 25 Index. It was launched on Dec 20, 2011.

Performance

PRAX vs. SMH - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Praxis Precision Medicines, Inc. (PRAX) and VanEck Semiconductor ETF (SMH). The values are adjusted to include any dividend payments, if applicable.

PRAX vs. SMH - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
PRAX Praxis Precision Medicines, Inc.	8.33%	282.98%	245.42%	-37.59%	-87.92%	-64.19%	97.91%
SMH VanEck Semiconductor ETF	8.84%	49.17%	39.10%	73.38%	-33.53%	42.13%	17.95%

Returns By Period

In the year-to-date period, PRAX achieves a 8.33% return, which is significantly lower than SMH's 8.84% return.

PRAX

• 1D: -0.90%
• 1M: -3.42%
• YTD: 8.33%
• 6M: 502.19%
• 1Y: 790.10%
• 3Y*: 197.42%
• 5Y*: -7.15%
• 10Y*: —

SMH

• 1D: 2.24%
• 1M: -3.55%
• YTD: 8.84%
• 6M: 17.83%
• 1Y: 85.04%
• 3Y*: 44.53%
• 5Y*: 26.15%
• 10Y*: 31.58%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PRAX vs. SMH — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PRAX

PRAX Risk / Return Rank: 99
PRAX Sharpe Ratio Rank: 98
PRAX Sortino Ratio Rank: 100
PRAX Omega Ratio Rank: 99
PRAX Calmar Ratio Rank: 100
PRAX Martin Ratio Rank: 100

SMH

SMH Risk / Return Rank: 95
SMH Sharpe Ratio Rank: 94
SMH Sortino Ratio Rank: 93
SMH Omega Ratio Rank: 92
SMH Calmar Ratio Rank: 97
SMH Martin Ratio Rank: 97

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PRAX vs. SMH - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Praxis Precision Medicines, Inc. (PRAX) and VanEck Semiconductor ETF (SMH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PRAX	SMH	Difference
Sharpe ratio Return per unit of total volatility	4.02	2.32	+1.71
Sortino ratio Return per unit of downside risk	7.71	2.92	+4.79
Omega ratio Gain probability vs. loss probability	1.95	1.41	+0.53
Calmar ratio Return relative to maximum drawdown	20.45	5.39	+15.07
Martin ratio Return relative to average drawdown	62.84	19.22	+43.62
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PRAX vs. SMH - Sharpe Ratio Comparison

The current PRAX Sharpe Ratio is 4.02, which is higher than the SMH Sharpe Ratio of 2.32. The chart below compares the historical Sharpe Ratios of PRAX and SMH, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PRAX	SMH	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	4.02	2.32	+1.71
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.06	0.76	-0.81
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.98	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.04	0.28	-0.32

Correlation

The correlation between PRAX and SMH is 0.22, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PRAX vs. SMH - Dividend Comparison

PRAX has not paid dividends to shareholders, while SMH's dividend yield for the trailing twelve months is around 0.28%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PRAX Praxis Precision Medicines, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SMH VanEck Semiconductor ETF	0.28%	0.31%	0.44%	0.60%	1.18%	0.51%	0.69%	1.50%	1.88%	1.43%	0.80%	2.14%

Drawdowns

PRAX vs. SMH - Drawdown Comparison

The maximum PRAX drawdown since its inception was -98.67%, which is greater than SMH's maximum drawdown of -84.96%. Use the drawdown chart below to compare losses from any high point for PRAX and SMH.

Drawdown Indicators

	PRAX	SMH	Difference
Max Drawdown Largest peak-to-trough decline	-98.67%	-84.96%	-13.71%
Max Drawdown (1Y) Largest decline over 1 year	-36.33%	-15.95%	-20.38%
Max Drawdown (5Y) Largest decline over 5 years	-97.57%	-45.30%	-52.27%
Max Drawdown (10Y) Largest decline over 10 years	—	-45.30%	—
Current Drawdown Current decline from peak	-64.64%	-8.02%	-56.62%
Average Drawdown Average peak-to-trough decline	-81.21%	-41.35%	-39.86%
Ulcer Index Depth and duration of drawdowns from previous peaks	11.82%	4.47%	+7.35%

Volatility

PRAX vs. SMH - Volatility Comparison

Praxis Precision Medicines, Inc. (PRAX) has a higher volatility of 21.15% compared to VanEck Semiconductor ETF (SMH) at 11.74%. This indicates that PRAX's price experiences larger fluctuations and is considered to be riskier than SMH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PRAX	SMH	Difference
Volatility (1M) Calculated over the trailing 1-month period	21.15%	11.74%	+9.41%
Volatility (6M) Calculated over the trailing 6-month period	118.56%	24.02%	+94.54%
Volatility (1Y) Calculated over the trailing 1-year period	198.35%	36.88%	+161.47%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	128.53%	34.68%	+93.85%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	125.44%	32.29%	+93.15%