- ISIN
- US74006W1080
- CUSIP
- 74006W108
- Sector
- Healthcare
- Industry
- Biotechnology
- IPO Date
- Oct 16, 2020
Highlights
- Market Cap
- $8.58B
- Enterprise Value
- $8.05B
- EPS (TTM)
- -$13.35
- Total Revenue (TTM)
- -$92.00K
- Gross Profit (TTM)
- -$128.83M
- EBITDA (TTM)
- -$344.68M
- Year Range
- $37.19 - $366.52
- Target Price
- $544.40
- ROA (TTM)
- -22.36%
- ROE (TTM)
- -23.16%
- Avg. Volume (1M)
- 354K
- Avg. Volume Value (1M)
- $111.78M
Share Price Chart
Loading charts...
Compare stocks, funds, or ETFs
Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.
Performance
PRAX Performance Chart
Praxis Precision Medicines, Inc. (PRAX) is up 4.4% since the beginning of the year. At $308 per share, PRAX is trading 16.0% below its 52-week high of $367. Investors who bought $1,000 worth of PRAX shares 5 years ago would now be looking at an investment worth $1,316.
Loading charts...
Compare this symbol against anything
Returns By Period
Praxis Precision Medicines, Inc. (PRAX) has returned 4.44% so far this year and 469.11% over the past 12 months.
Praxis Precision Medicines, Inc.
- 1D
- 0.03%
- 1M
- -3.36%
- 6M
- -1.96%
- YTD
- 4.44%
- 1Y
- 469.11%
- 3Y*
- 177.75%
- 5Y*
- 5.64%
- 10Y*
- —
- ALL TIME*
- -3.97%
Benchmark (S&P 500 Index)
- 1D
- 0.70%
- 1M
- 0.09%
- 6M
- 7.94%
- YTD
- 9.41%
- 1Y
- 20.07%
- 3Y*
- 17.84%
- 5Y*
- 11.25%
- 10Y*
- 13.26%
- ALL TIME*
- 8.09%
PRAX Monthly Returns History
Based on dividend-adjusted daily data since Oct 16, 2020, PRAX's average daily return is +0.27%, while the average monthly return is +6.44%. At this rate, an investment would double in approximately 0.9 years.
Historically, 47% of months were positive and 53% were negative. The best month was Oct 2025 with a return of +275.0%, while the worst month was Mar 2023 at -73.6%. The longest winning streak lasted 5 consecutive months, and the longest losing streak was 7 months.
On a daily basis, PRAX closed higher 50% of trading days. The best single day was Oct 16, 2025 with a return of +183.7%, while the worst single day was Jun 6, 2022 at -78.1%.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | 6.53% | 7.25% | -4.32% | -1.04% | 9.77% | -4.34% | -8.05% | 4.44% | |||||
| 2025 | -0.53% | -49.58% | -1.89% | -0.61% | 2.42% | 9.08% | 28.94% | -16.01% | 16.38% | 275.02% | -1.16% | 50.03% | 282.98% |
| 2024 | 95.83% | 7.22% | 30.44% | -10.08% | -13.50% | -12.85% | 39.53% | -7.90% | 8.26% | 21.64% | 14.54% | -4.00% | 245.42% |
| 2023 | 109.24% | -38.45% | -73.61% | 28.55% | -17.33% | 33.75% | -13.90% | 48.47% | 16.33% | -39.77% | 17.80% | 22.42% | -37.59% |
| 2022 | -24.57% | -11.84% | -22.06% | -20.67% | 2.47% | -70.48% | 44.08% | -11.61% | -27.24% | -13.22% | 12.18% | 7.69% | -87.92% |
| 2021 | -7.51% | -14.52% | -24.69% | -6.41% | -36.11% | -6.69% | -14.66% | 27.37% | -6.95% | 12.49% | -17.74% | 15.14% | -64.19% |
Benchmark Metrics
Praxis Precision Medicines, Inc. has an annualized alpha of 66.82%, beta of 1.08, and R2 of 0.02 versus S&P 500 Index. Calculated based on daily prices since October 16, 2020.
- This stock participated in 213.92% of S&P 500 Index downside but only 196.52% of its upside - more exposed to losses than it benefited from rallies.
- R2 of 0.02 means this stock moves largely independently of S&P 500 Index - capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.
- Alpha
- 66.82%
- Beta
- 1.08
- R²
- 0.02
- Upside Capture
- 196.52%
- Downside Capture
- 213.92%
Return for Risk
Risk / Return Rank
PRAX ranks 98 for risk / return — above 98% of stocks peers on PortfoliosLab. Its historical combined result is among the stronger results in the peer group.
Risk / Return Metrics
The table below present risk-adjusted performance metrics for Praxis Precision Medicines, Inc. (PRAX) and compare them to S&P 500 Index.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| PRAX | Benchmark | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.95 | ||
| Sortino ratioReturn per unit of downside risk | +4.13 | ||
| Omega ratioGain probability vs. loss probability | 1.76 | 1.25 | +0.51 |
| Calmar ratioReturn relative to maximum drawdown | 14.46 | 2.00 | +12.46 |
| Martin ratioReturn relative to average drawdown | 41.02 | 8.49 | +32.53 |
Dividends
Dividend History
Drawdowns
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.
Loading charts...
Worst Drawdowns
The table below displays the maximum drawdowns of the Praxis Precision Medicines, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.
The maximum drawdown for the Praxis Precision Medicines, Inc. was 98.67%, occurring on Mar 30, 2023. The portfolio has not yet recovered.
The current Praxis Precision Medicines, Inc. drawdown is 65.91%.
Drawdown | Fall | Recovery | Underwater | Related event |
|---|---|---|---|---|
-98.67%Mar 2023 | 2y 2mo | — | 5y 6moJan 2021 - now | — |
-21.78%Nov 2020 | 1d | 15d | 15dNov 2020 - Nov 2020 | — |
-8.01%Dec 2020 | 1d | 8d | 8dDec 2020 - Jan 2021 | — |
-7.00%Dec 2020 | 1d | 7d | 7dDec 2020 - Dec 2020 | — |
-6.29%Nov 2020 | 1d | 6d | 7dNov 2020 - Nov 2020 | — |
Drawdown Indicators
| PRAX | Benchmark | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -98.67% | -56.78% | -41.89% |
Max Drawdown (1Y)Largest decline over 1 year | -32.61% | -9.10% | -23.51% |
Max Drawdown (3Y)Largest decline over 3 years | -68.64% | -18.90% | -49.74% |
Max Drawdown (5Y)Largest decline over 5 years | -96.50% | -25.43% | -71.07% |
Max Drawdown (10Y)Largest decline over 10 years | — | -33.92% | — |
Current DrawdownCurrent decline from peak | -65.91% | -1.58% | -64.33% |
Average DrawdownAverage peak-to-trough decline | -80.22% | -10.70% | -69.52% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 11.52% | 2.14% | +9.38% |
Volatility
Volatility Chart
The chart below shows the rolling one-month volatility.
Loading charts...
Financials
Financial Performance
The chart below illustrates the trends in the financial health of Praxis Precision Medicines, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.
Valuation
The Valuation section provides an overview of how Praxis Precision Medicines, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.
PB Ratio
The chart illustrates the Price-to-Book (P/B) ratio for PRAX in comparison with other companies in the Biotechnology industry. Currently, PRAX has a P/B value of 6.3. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.
Income Statement
| TTM | |
|---|---|
Revenue | |
Total Revenue | — |
Cost Of Revenue | — |
Gross Profit | — |
Operating Expenses | |
Selling, General & Admin Expenses | — |
R&D Expenses | — |
Depreciation And Amortization | — |
Total Operating Expenses | — |
Income | |
Income Before Tax | — |
Operating Income | — |
EBITDA | — |
EBIT | — |
Earnings From Continuing Operations | — |
Net Income | — |
Income Tax Expense | — |
Other Non-Operating Income (Expenses) | — |
Extraordinary Items | — |
Discontinued Operations | — |
Effect Of Accounting Charges | — |
Non Recurring | — |
Minority Interest | — |
Other Items | — |
Interest Income | — |
Interest Expense | — |
Net Interest Income | — |
Build a portfolio with PRAX
Add Praxis Precision Medicines, Inc. to a portfolio and analyze allocations for your target — whether that's maximizing returns, minimizing drawdowns, or balancing risk across holdings.
Open Portfolio Analyzer with PRAX