PGEN vs. VTI

Last updated Jun 23, 2026

PGEN (Precigen, Inc.) is a stock, while VTI (Vanguard Total Stock Market ETF) is Large Cap Blend Equities fund tracking the CRSP US Total Market Index. Over the past 10 years, PGEN returned -13.73%/yr vs 15.31%/yr for VTI. At a 0.39 correlation, their price movements are largely independent.

Performance

PGEN vs. VTI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Precigen, Inc. (PGEN) and Vanguard Total Stock Market ETF (VTI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PGEN achieves a 28.71% return, which is significantly higher than VTI's 10.35% return. Over the past 10 years, PGEN has underperformed VTI with an annualized return of -13.73%, while VTI has yielded a comparatively higher 15.31% annualized return.

PGEN

• 1D: 11.62%
• 1M: 26.89%
• YTD: 28.71%
• 6M: 22.83%
• 1Y: 271.03%
• 3Y*: 68.23%
• 5Y*: -4.01%
• 10Y*: -13.73%

VTI

• 1D: -0.32%
• 1M: 0.55%
• YTD: 10.35%
• 6M: 9.59%
• 1Y: 27.18%
• 3Y*: 21.19%
• 5Y*: 12.36%
• 10Y*: 15.31%

*Multi-year figures are annualized to reflect compound growth (CAGR)

PGEN vs. VTI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PGEN Precigen, Inc.	28.71%	273.21%	-16.42%	-11.84%	-59.03%	-63.63%	86.13%	-16.21%	-43.23%	-51.70%
VTI Vanguard Total Stock Market ETF	10.35%	17.10%	23.81%	26.05%	-19.52%	25.68%	21.08%	30.67%	-5.23%	21.21%

Correlation

The correlation between PGEN and VTI is 0.27, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.27
Correlation (3Y) Calculated over the trailing 3-year period	0.37
Correlation (5Y) Calculated over the trailing 5-year period	0.42
Correlation (10Y) Calculated over the trailing 10-year period	0.40
Correlation (All Time) Calculated using the full available price history since Aug 8, 2013	0.39

The correlation between PGEN and VTI shifts across timeframes, from 0.27 (1 year) to 0.42 (5 years), reflecting how their relationship changes across market environments.

Return for Risk

PGEN vs. VTI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PGEN

PGEN Risk / Return Rank: 93
PGEN Sharpe Ratio Rank: 93
PGEN Sortino Ratio Rank: 93
PGEN Omega Ratio Rank: 90
PGEN Calmar Ratio Rank: 95
PGEN Martin Ratio Rank: 92

VTI

VTI Risk / Return Rank: 68
VTI Sharpe Ratio Rank: 68
VTI Sortino Ratio Rank: 66
VTI Omega Ratio Rank: 67
VTI Calmar Ratio Rank: 64
VTI Martin Ratio Rank: 74

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PGEN vs. VTI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Precigen, Inc. (PGEN) and Vanguard Total Stock Market ETF (VTI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	PGEN	VTI	Difference
Sharpe ratio: Return per unit of total volatility	2.59	2.14	+0.45
Sortino ratio: Return per unit of downside risk	3.59	2.90	+0.69
Omega ratio: Gain probability vs. loss probability	1.42	1.38	+0.03
Calmar ratio: Return relative to maximum drawdown	6.74	3.06	+3.68
Martin ratio: Return relative to average drawdown	13.93	13.68	+0.26

PGEN vs. VTI - Sharpe Ratio Comparison

The current PGEN Sharpe Ratio is 2.59, which is comparable to the VTI Sharpe Ratio of 2.14. The chart below compares the historical Sharpe Ratios of PGEN and VTI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

PGEN vs. VTI - Drawdown Comparison

The maximum PGEN drawdown since its inception was -99.00%, which is greater than VTI's maximum drawdown of -55.45%. Use the drawdown chart below to compare losses from any high point for PGEN and VTI.

Drawdown Indicators

	PGEN	VTI	Difference
Max Drawdown Largest peak-to-trough decline	-99.00%	-55.45%	-43.55%
Max Drawdown (1Y) Largest decline over 1 year	-40.50%	-8.92%	-31.58%
Max Drawdown (3Y) Largest decline over 3 years	-64.17%	-19.30%	-44.87%
Max Drawdown (5Y) Largest decline over 5 years	-90.12%	-25.36%	-64.76%
Max Drawdown (10Y) Largest decline over 10 years	-97.90%	-35.00%	-62.90%
Current Drawdown Current decline from peak	-92.02%	-1.48%	-90.54%
Average Drawdown Average peak-to-trough decline	-76.52%	-8.01%	-68.51%
Ulcer Index Depth and duration of drawdowns from previous peaks	19.55%	1.99%	+17.56%

Volatility

PGEN vs. VTI - Volatility Comparison

Precigen, Inc. (PGEN) has a higher volatility of 25.00% compared to Vanguard Total Stock Market ETF (VTI) at 4.74%. This indicates that PGEN's price experiences larger fluctuations and is considered to be riskier than VTI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PGEN	VTI	Difference
Volatility (1M) Calculated over the trailing 1-month period	25.00%	4.74%	+20.26%
Volatility (6M) Calculated over the trailing 6-month period	58.98%	9.96%	+49.02%
Volatility (1Y) Calculated over the trailing 1-year period	105.54%	12.76%	+92.78%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	88.50%	17.49%	+71.01%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	91.60%	18.35%	+73.25%

Dividends

PGEN vs. VTI - Dividend Comparison

PGEN has not paid dividends to shareholders, while VTI's dividend yield for the trailing twelve months is around 1.02%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PGEN Precigen, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	2.09%	0.00%	5.66%
VTI Vanguard Total Stock Market ETF	1.02%	1.12%	1.27%	1.44%	1.66%	1.21%	1.42%	1.78%	2.04%	1.71%	1.92%	1.98%

Frequently Asked Questions

Can I hold both PGEN and VTI in my portfolio?

PGEN and VTI have a correlation of 0.27, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PGEN or VTI?

PGEN has higher volatility (25.00%) compared to VTI (4.74%). In terms of maximum drawdown, PGEN dropped -99.00% vs VTI's -55.45%.

Which has better risk-adjusted returns?

PGEN currently has the higher Sharpe Ratio (2.59 vs 2.14), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.