OZEM vs. IXJ

Last updated Apr 1, 2026

Compare and contrast key facts about Roundhill Glp-1 & Weight Loss ETF (OZEM) and iShares Global Healthcare ETF (IXJ).

OZEM and IXJ are both exchange-traded funds (ETFs), meaning they are traded on stock exchanges and can be bought and sold throughout the day. OZEM is an actively managed fund by Roundhill. It was launched on May 20, 2024. IXJ is a passively managed fund by iShares that tracks the performance of the S&P Global Healthcare Sector Index. It was launched on Nov 13, 2001.

Performance

OZEM vs. IXJ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Roundhill Glp-1 & Weight Loss ETF (OZEM) and iShares Global Healthcare ETF (IXJ). The values are adjusted to include any dividend payments, if applicable.

OZEM vs. IXJ - Yearly Performance Comparison

	2026 (YTD)	2025	2024
OZEM Roundhill Glp-1 & Weight Loss ETF	-8.66%	41.87%	-3.78%
IXJ iShares Global Healthcare ETF	-3.96%	14.99%	-6.49%

Returns By Period

In the year-to-date period, OZEM achieves a -8.66% return, which is significantly lower than IXJ's -3.96% return.

OZEM

• 1D: 3.13%
• 1M: -7.94%
• YTD: -8.66%
• 6M: 15.54%
• 1Y: 33.42%
• 3Y*: —
• 5Y*: —
• 10Y*: —

IXJ

• 1D: 1.96%
• 1M: -8.03%
• YTD: -3.96%
• 6M: 6.20%
• 1Y: 4.10%
• 3Y*: 5.42%
• 5Y*: 5.33%
• 10Y*: 8.40%

*Multi-year figures are annualized to reflect compound growth (CAGR)

OZEM vs. IXJ - Expense Ratio Comparison

OZEM has a 0.59% expense ratio, which is higher than IXJ's 0.46% expense ratio.

OZEM

Roundhill Glp-1 & Weight Loss ETF

IXJ

iShares Global Healthcare ETF

Return for Risk

OZEM vs. IXJ — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

OZEM

OZEM Risk / Return Rank: 64
OZEM Sharpe Ratio Rank: 69
OZEM Sortino Ratio Rank: 70
OZEM Omega Ratio Rank: 59
OZEM Calmar Ratio Rank: 70
OZEM Martin Ratio Rank: 51

IXJ

IXJ Risk / Return Rank: 20
IXJ Sharpe Ratio Rank: 19
IXJ Sortino Ratio Rank: 19
IXJ Omega Ratio Rank: 18
IXJ Calmar Ratio Rank: 23
IXJ Martin Ratio Rank: 20

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

OZEM vs. IXJ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Roundhill Glp-1 & Weight Loss ETF (OZEM) and iShares Global Healthcare ETF (IXJ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	OZEM	IXJ	Difference
Sharpe ratio Return per unit of total volatility	1.22	0.24	+0.98
Sortino ratio Return per unit of downside risk	1.76	0.45	+1.31
Omega ratio Gain probability vs. loss probability	1.22	1.06	+0.16
Calmar ratio Return relative to maximum drawdown	1.78	0.44	+1.34
Martin ratio Return relative to average drawdown	4.85	1.04	+3.81
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

OZEM vs. IXJ - Sharpe Ratio Comparison

The current OZEM Sharpe Ratio is 1.22, which is higher than the IXJ Sharpe Ratio of 0.24. The chart below compares the historical Sharpe Ratios of OZEM and IXJ, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	OZEM	IXJ	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.22	0.24	+0.98
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.38	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.54	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.50	0.42	+0.08

Correlation

The correlation between OZEM and IXJ is 0.68, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.

Dividends

OZEM vs. IXJ - Dividend Comparison

OZEM's dividend yield for the trailing twelve months is around 1.31%, less than IXJ's 1.45% yield.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
OZEM Roundhill Glp-1 & Weight Loss ETF	1.31%	1.20%	0.22%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
IXJ iShares Global Healthcare ETF	1.45%	1.40%	1.50%	1.38%	1.17%	1.12%	1.27%	1.42%	2.11%	1.46%	1.73%	2.85%

Drawdowns

OZEM vs. IXJ - Drawdown Comparison

The maximum OZEM drawdown since its inception was -28.65%, smaller than the maximum IXJ drawdown of -40.60%. Use the drawdown chart below to compare losses from any high point for OZEM and IXJ.

Drawdown Indicators

	OZEM	IXJ	Difference
Max Drawdown Largest peak-to-trough decline	-28.65%	-40.60%	+11.95%
Max Drawdown (1Y) Largest decline over 1 year	-19.11%	-10.35%	-8.76%
Max Drawdown (5Y) Largest decline over 5 years	—	-18.14%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-27.35%	—
Current Drawdown Current decline from peak	-15.70%	-8.03%	-7.67%
Average Drawdown Average peak-to-trough decline	-8.30%	-6.92%	-1.38%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.02%	4.41%	+2.61%

Volatility

OZEM vs. IXJ - Volatility Comparison

Roundhill Glp-1 & Weight Loss ETF (OZEM) has a higher volatility of 6.60% compared to iShares Global Healthcare ETF (IXJ) at 5.06%. This indicates that OZEM's price experiences larger fluctuations and is considered to be riskier than IXJ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	OZEM	IXJ	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.60%	5.06%	+1.54%
Volatility (6M) Calculated over the trailing 6-month period	17.54%	10.43%	+7.11%
Volatility (1Y) Calculated over the trailing 1-year period	27.62%	17.31%	+10.31%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.37%	14.07%	+11.30%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.37%	15.66%	+9.71%