OVID vs. LXRX

Last updated Jun 4, 2026

OVID (Ovid Therapeutics Inc.) and LXRX (Lexicon Pharmaceuticals, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, OVID returned -11.41%/yr vs -16.06%/yr for LXRX. At a 0.26 correlation, their price movements are largely independent.

Performance

OVID vs. LXRX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Ovid Therapeutics Inc. (OVID) and Lexicon Pharmaceuticals, Inc. (LXRX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, OVID achieves a 46.63% return, which is significantly lower than LXRX's 60.87% return.

OVID

• 1D: -0.42%
• 1M: -18.43%
• YTD: 46.63%
• 6M: 51.27%
• 1Y: 700.13%
• 3Y*: -13.28%
• 5Y*: -11.41%
• 10Y*: —

LXRX

• 1D: -2.12%
• 1M: 15.62%
• YTD: 60.87%
• 6M: 32.14%
• 1Y: 192.72%
• 3Y*: -12.32%
• 5Y*: -16.06%
• 10Y*: -18.68%

*Multi-year figures are annualized to reflect compound growth (CAGR)

OVID vs. LXRX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
OVID Ovid Therapeutics Inc.	46.63%	74.57%	-71.00%	73.12%	-42.06%	38.96%	-44.34%	71.49%	-75.48%	-19.43%
LXRX Lexicon Pharmaceuticals, Inc.	60.87%	55.72%	-51.73%	-19.90%	-51.52%	15.20%	-17.59%	-37.50%	-32.79%	-38.29%

Correlation

The correlation between OVID and LXRX is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.34
Correlation (3Y) Calculated over the trailing 3-year period	0.32
Correlation (5Y) Calculated over the trailing 5-year period	0.31
Correlation (All Time) Calculated using the full available price history since May 8, 2017	0.26

Fundamentals

Market Cap OVID : $325.45M LXRX : $740.44M
EPS OVID : -$0.27 LXRX : -$0.07
PS Ratio OVID : 30.21 LXRX : 9.90
PB Ratio OVID : 1.64 LXRX : 3.65
Total Revenue (TTM) OVID : $7.12M LXRX : $69.64M
Gross Profit (TTM) OVID : $7.06M LXRX : $69.00M
EBITDA (TTM) OVID : -$47.25M LXRX : -$20.38M

Return for Risk

OVID vs. LXRX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

OVID

OVID Risk / Return Rank: 98
OVID Sharpe Ratio Rank: 99
OVID Sortino Ratio Rank: 97
OVID Omega Ratio Rank: 95
OVID Calmar Ratio Rank: 99
OVID Martin Ratio Rank: 99

LXRX

LXRX Risk / Return Rank: 89
LXRX Sharpe Ratio Rank: 90
LXRX Sortino Ratio Rank: 87
LXRX Omega Ratio Rank: 83
LXRX Calmar Ratio Rank: 93
LXRX Martin Ratio Rank: 90

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

OVID vs. LXRX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Ovid Therapeutics Inc. (OVID) and Lexicon Pharmaceuticals, Inc. (LXRX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	OVID	LXRX	Difference
Sharpe ratio Return per unit of total volatility	6.24	2.26	+3.98
Sortino ratio Return per unit of downside risk	4.75	2.87	+1.88
Omega ratio Gain probability vs. loss probability	1.58	1.34	+0.24
Calmar ratio Return relative to maximum drawdown	20.32	5.69	+14.63
Martin ratio Return relative to average drawdown	50.85	12.51	+38.34
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

OVID vs. LXRX - Sharpe Ratio Comparison

The current OVID Sharpe Ratio is 6.24, which is higher than the LXRX Sharpe Ratio of 2.26. The chart below compares the historical Sharpe Ratios of OVID and LXRX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	OVID	LXRX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	6.24	2.26	+3.98
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.14	-0.16	+0.02
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	-0.19	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.19	-0.17	-0.02

Drawdowns

OVID vs. LXRX - Drawdown Comparison

The maximum OVID drawdown since its inception was -98.30%, roughly equal to the maximum LXRX drawdown of -99.91%. Use the drawdown chart below to compare losses from any high point for OVID and LXRX.

Drawdown Indicators

	OVID	LXRX	Difference
Max Drawdown Largest peak-to-trough decline	-98.30%	-99.91%	+1.61%
Max Drawdown (1Y) Largest decline over 1 year	-34.78%	-34.09%	-0.69%
Max Drawdown (3Y) Largest decline over 3 years	-93.69%	-91.83%	-1.86%
Max Drawdown (5Y) Largest decline over 5 years	-94.32%	-95.25%	+0.93%
Max Drawdown (10Y) Largest decline over 10 years	—	-98.48%	—
Current Drawdown Current decline from peak	-84.07%	-99.44%	+15.37%
Average Drawdown Average peak-to-trough decline	-75.11%	-93.20%	+18.09%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.87%	15.48%	-1.61%

Volatility

OVID vs. LXRX - Volatility Comparison

The current volatility for Ovid Therapeutics Inc. (OVID) is 16.65%, while Lexicon Pharmaceuticals, Inc. (LXRX) has a volatility of 29.25%. This indicates that OVID experiences smaller price fluctuations and is considered to be less risky than LXRX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	OVID	LXRX	Difference
Volatility (1M) Calculated over the trailing 1-month period	16.65%	29.25%	-12.60%
Volatility (6M) Calculated over the trailing 6-month period	58.76%	58.59%	+0.17%
Volatility (1Y) Calculated over the trailing 1-year period	113.35%	85.81%	+27.54%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	79.90%	98.26%	-18.36%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	85.71%	97.22%	-11.51%

Dividends

OVID vs. LXRX - Dividend Comparison

Neither OVID nor LXRX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both OVID and LXRX in my portfolio?

OVID and LXRX have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, OVID or LXRX?

LXRX has higher volatility (29.25%) compared to OVID (16.65%). In terms of maximum drawdown, OVID dropped -98.30% vs LXRX's -99.91%.

Which has better risk-adjusted returns?

OVID currently has the higher Sharpe Ratio (6.24 vs 2.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.