NAGE vs. VSGX

Last updated Apr 2, 2026

Compare and contrast key facts about Niagen Bioscience, Inc (NAGE) and Vanguard ESG International Stock ETF (VSGX).

VSGX is a passively managed fund by Vanguard that tracks the performance of the FTSE Global All Cap ex US Choice Index.. It was launched on Sep 18, 2018.

Performance

NAGE vs. VSGX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Niagen Bioscience, Inc (NAGE) and Vanguard ESG International Stock ETF (VSGX). The values are adjusted to include any dividend payments, if applicable.

NAGE vs. VSGX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
NAGE Niagen Bioscience, Inc	-28.93%	19.89%	270.98%	-14.88%	-55.08%	-22.08%	11.37%	25.66%	-12.72%
VSGX Vanguard ESG International Stock ETF	1.06%	30.77%	5.72%	15.62%	-18.61%	7.24%	13.01%	23.04%	-12.87%

Returns By Period

In the year-to-date period, NAGE achieves a -28.93% return, which is significantly lower than VSGX's 1.06% return.

NAGE

• 1D: 2.49%
• 1M: -9.42%
• YTD: -28.93%
• 6M: -42.71%
• 1Y: -34.21%
• 3Y*: 43.49%
• 5Y*: -14.15%
• 10Y*: 0.52%

VSGX

• 1D: -1.03%
• 1M: -3.28%
• YTD: 1.06%
• 6M: 4.54%
• 1Y: 25.60%
• 3Y*: 14.70%
• 5Y*: 6.05%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

NAGE vs. VSGX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

NAGE

NAGE Risk / Return Rank: 20
NAGE Sharpe Ratio Rank: 14
NAGE Sortino Ratio Rank: 16
NAGE Omega Ratio Rank: 17
NAGE Calmar Ratio Rank: 25
NAGE Martin Ratio Rank: 27

VSGX

VSGX Risk / Return Rank: 71
VSGX Sharpe Ratio Rank: 76
VSGX Sortino Ratio Rank: 74
VSGX Omega Ratio Rank: 73
VSGX Calmar Ratio Rank: 67
VSGX Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

NAGE vs. VSGX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Niagen Bioscience, Inc (NAGE) and Vanguard ESG International Stock ETF (VSGX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	NAGE	VSGX	Difference
Sharpe ratio Return per unit of total volatility	-0.61	1.46	-2.07
Sortino ratio Return per unit of downside risk	-0.62	2.00	-2.63
Omega ratio Gain probability vs. loss probability	0.93	1.29	-0.36
Calmar ratio Return relative to maximum drawdown	-0.49	2.02	-2.51
Martin ratio Return relative to average drawdown	-0.79	7.79	-8.58
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

NAGE vs. VSGX - Sharpe Ratio Comparison

The current NAGE Sharpe Ratio is -0.61, which is lower than the VSGX Sharpe Ratio of 1.46. The chart below compares the historical Sharpe Ratios of NAGE and VSGX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	NAGE	VSGX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.61	1.46	-2.07
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.18	0.38	-0.56
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.01	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.02	0.41	-0.43

Correlation

The correlation between NAGE and VSGX is 0.31, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

NAGE vs. VSGX - Dividend Comparison

NAGE has not paid dividends to shareholders, while VSGX's dividend yield for the trailing twelve months is around 3.26%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018
NAGE Niagen Bioscience, Inc	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VSGX Vanguard ESG International Stock ETF	3.26%	3.23%	3.10%	2.77%	2.61%	2.49%	1.67%	2.28%	0.38%

Drawdowns

NAGE vs. VSGX - Drawdown Comparison

The maximum NAGE drawdown since its inception was -97.00%, which is greater than VSGX's maximum drawdown of -33.09%. Use the drawdown chart below to compare losses from any high point for NAGE and VSGX.

Drawdown Indicators

	NAGE	VSGX	Difference
Max Drawdown Largest peak-to-trough decline	-97.00%	-33.09%	-63.91%
Max Drawdown (1Y) Largest decline over 1 year	-70.85%	-12.84%	-58.01%
Max Drawdown (5Y) Largest decline over 5 years	-89.10%	-32.14%	-56.96%
Max Drawdown (10Y) Largest decline over 10 years	-93.65%	—	—
Current Drawdown Current decline from peak	-75.88%	-9.45%	-66.43%
Average Drawdown Average peak-to-trough decline	-75.71%	-7.90%	-67.81%
Ulcer Index Depth and duration of drawdowns from previous peaks	43.61%	3.33%	+40.28%

Volatility

NAGE vs. VSGX - Volatility Comparison

Niagen Bioscience, Inc (NAGE) has a higher volatility of 13.64% compared to Vanguard ESG International Stock ETF (VSGX) at 8.18%. This indicates that NAGE's price experiences larger fluctuations and is considered to be riskier than VSGX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	NAGE	VSGX	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.64%	8.18%	+5.46%
Volatility (6M) Calculated over the trailing 6-month period	34.23%	12.27%	+21.96%
Volatility (1Y) Calculated over the trailing 1-year period	56.36%	17.57%	+38.79%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	77.58%	15.98%	+61.60%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	79.93%	17.95%	+61.98%