MIST vs. UNCY

Last updated Aug 1, 2026

MIST (Milestone Pharmaceuticals Inc.) and UNCY (Unicycive Therapeutics Inc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, MIST returned -27.91%/yr vs -28.91%/yr for UNCY. Their 0.15 correlation means their historical movements had little consistent relationship.

Performance

MIST vs. UNCY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Milestone Pharmaceuticals Inc. (MIST) and Unicycive Therapeutics Inc (UNCY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, MIST achieves a -45.05% return, which is significantly lower than UNCY's -13.17% return.

MIST

• 1D: -3.48%
• 1M: -15.91%
• 6M: -41.88%
• YTD: -45.05%
• 1Y: -22.38%
• 3Y*: -29.52%
• 5Y*: -27.91%
• 10Y*: —
• ALL TIME*: -30.63%

UNCY

• 1D: -5.47%
• 1M: -12.57%
• 6M: -16.08%
• YTD: -13.17%
• 1Y: 19.29%
• 3Y*: -24.41%
• 5Y*: -28.91%
• 10Y*: —
• ALL TIME*: -36.58%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
MIST Milestone Pharmaceuticals Inc.	$1.41M	$1.40M	$1.91M
UNCY Unicycive Therapeutics Inc	$4.23M	$6.09M	$9.40M

MIST vs. UNCY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
MIST Milestone Pharmaceuticals Inc.	-45.05%	-14.41%	41.32%	-57.83%	-39.54%	19.74%
UNCY Unicycive Therapeutics Inc	-13.17%	-27.35%	-8.47%	60.69%	-73.79%	-58.80%

Correlation

The correlation between MIST and UNCY is 0.33, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.33
Correlation (3Y) Balances recent behavior with more history.	0.20
Correlation (5Y) Shows whether the relationship held over a longer period.	0.15
Correlation (All Time) Calculated using the full available price history since Jul 12, 2021	0.15

The correlation between MIST and UNCY shifts across timeframes, from 0.15 (5 years) to 0.33 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap MIST : $95.34M UNCY : $133.77M
EPS MIST : -$0.45 UNCY : -$0.29
PB Ratio MIST : 4.01 UNCY : 31.77
Total Revenue (TTM) MIST : $1.78M UNCY : $0.00
Gross Profit (TTM) MIST : $1.75M UNCY : $0.00
EBITDA (TTM) MIST : -$63.04M UNCY : -$35.07M

Return for Risk

MIST vs. UNCY — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

MIST

MIST Risk / Return Rank: 31
MIST Sharpe Ratio Rank: 29
MIST Sortino Ratio Rank: 32
MIST Omega Ratio Rank: 32
MIST Calmar Ratio Rank: 32
MIST Martin Ratio Rank: 32

UNCY

UNCY Risk / Return Rank: 55
UNCY Sharpe Ratio Rank: 52
UNCY Sortino Ratio Rank: 54
UNCY Omega Ratio Rank: 56
UNCY Calmar Ratio Rank: 53
UNCY Martin Ratio Rank: 58

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

MIST vs. UNCY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Milestone Pharmaceuticals Inc. (MIST) and Unicycive Therapeutics Inc (UNCY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	MIST	UNCY	Difference
Sharpe ratio: Return per unit of total volatility	-0.33	0.20	-0.53
Sortino ratio: Return per unit of downside risk	-0.04	0.81	-0.85
Omega ratio: Gain probability vs. loss probability	1.00	1.12	-0.12
Calmar ratio: Return relative to maximum drawdown	-0.36	0.34	-0.70
Martin ratio: Return relative to average drawdown	-0.64	1.05	-1.70

MIST vs. UNCY - Sharpe Ratio Comparison

The current MIST Sharpe Ratio is -0.33, which is lower than the UNCY Sharpe Ratio of 0.20. The chart below compares the historical Sharpe Ratios of MIST and UNCY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

MIST vs. UNCY - Drawdown Comparison

The maximum MIST drawdown since its inception was -97.60%, roughly equal to the maximum UNCY drawdown of -95.97%. Use the drawdown chart below to compare losses from any high point for MIST and UNCY.

Drawdown Indicators

	MIST	UNCY	Difference
Max Drawdown Largest peak-to-trough decline	-97.60%	-95.97%	-1.63%
Max Drawdown (1Y) Largest decline over 1 year	-65.76%	-45.21%	-20.55%
Max Drawdown (3Y) Largest decline over 3 years	-81.18%	-86.82%	+5.64%
Max Drawdown (5Y) Largest decline over 5 years	-93.13%	-92.26%	-0.87%
Current Drawdown Current decline from peak	-95.91%	-91.44%	-4.47%
Average Drawdown Average peak-to-trough decline	-78.60%	-83.05%	+4.45%
Ulcer Index Depth and duration of drawdowns from previous peaks	36.42%	14.72%	+21.70%

Volatility

MIST vs. UNCY - Volatility Comparison

The current volatility for Milestone Pharmaceuticals Inc. (MIST) is 18.08%, while Unicycive Therapeutics Inc (UNCY) has a volatility of 21.35%. This indicates that MIST experiences smaller price fluctuations and is considered to be less risky than UNCY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MIST	UNCY	Difference
Volatility (1M) Calculated over the trailing 1-month period	18.08%	21.35%	-3.27%
Volatility (6M) Calculated over the trailing 6-month period	55.16%	71.93%	-16.77%
Volatility (1Y) Calculated over the trailing 1-year period	70.52%	78.88%	-8.36%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	78.04%	118.98%	-40.94%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	104.47%	120.08%	-15.61%

Dividends

MIST vs. UNCY - Dividend Comparison

Neither MIST nor UNCY has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both MIST and UNCY in my portfolio?

MIST and UNCY have a correlation of 0.33, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, MIST or UNCY?

UNCY has higher volatility (21.35%) compared to MIST (18.08%). In terms of maximum drawdown, MIST dropped -97.60% vs UNCY's -95.97%.

Which has better risk-adjusted returns?

UNCY currently has the higher Sharpe Ratio (0.20 vs -0.33), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.