MIST vs. MSFT

Last updated Jun 23, 2026

MIST (Milestone Pharmaceuticals Inc.) and MSFT (Microsoft Corporation) are both stocks. MIST operates in Biotechnology (Healthcare), while MSFT operates in Software - Infrastructure (Technology). Over the past 5 years, MIST returned -26.09%/yr vs 7.61%/yr for MSFT. At a 0.12 correlation, their price movements are largely independent.

Performance

MIST vs. MSFT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Milestone Pharmaceuticals Inc. (MIST) and Microsoft Corporation (MSFT). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, MIST achieves a -35.15% return, which is significantly lower than MSFT's -23.71% return.

MIST

• 1D: 0.77%
• 1M: -7.09%
• YTD: -35.15%
• 6M: -36.71%
• 1Y: -22.49%
• 3Y*: -25.36%
• 5Y*: -26.09%
• 10Y*: —

MSFT

• 1D: -3.18%
• 1M: -12.24%
• YTD: -23.71%
• 6M: -23.91%
• 1Y: -22.44%
• 3Y*: 3.92%
• 5Y*: 7.61%
• 10Y*: 23.62%

*Multi-year figures are annualized to reflect compound growth (CAGR)

MIST vs. MSFT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
MIST Milestone Pharmaceuticals Inc.	-35.15%	-14.41%	41.32%	-57.83%	-39.54%	-2.24%	-58.15%	2.56%
MSFT Microsoft Corporation	-23.71%	15.58%	12.93%	58.19%	-28.02%	52.48%	42.53%	26.96%

Correlation

The correlation between MIST and MSFT is 0.17, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.17
Correlation (3Y) Calculated over the trailing 3-year period	0.09
Correlation (5Y) Calculated over the trailing 5-year period	0.11
Correlation (All Time) Calculated using the full available price history since May 9, 2019	0.12

Fundamentals

Market Cap MIST : $170.67M MSFT : $2.73T
EPS MIST : -$0.49 MSFT : $16.79
PS Ratio MIST : 63.69 MSFT : 8.61
PB Ratio MIST : 4.73 MSFT : 6.60
Total Revenue (TTM) MIST : $1.78M MSFT : $318.27B
Gross Profit (TTM) MIST : $1.75M MSFT : $217.41B
EBITDA (TTM) MIST : -$63.04M MSFT : $200.96B

Return for Risk

MIST vs. MSFT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MIST

MIST Risk / Return Rank: 33
MIST Sharpe Ratio Rank: 30
MIST Sortino Ratio Rank: 36
MIST Omega Ratio Rank: 36
MIST Calmar Ratio Rank: 30
MIST Martin Ratio Rank: 30

MSFT

MSFT Risk / Return Rank: 11
MSFT Sharpe Ratio Rank: 8
MSFT Sortino Ratio Rank: 10
MSFT Omega Ratio Rank: 10
MSFT Calmar Ratio Rank: 17
MSFT Martin Ratio Rank: 10

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MIST vs. MSFT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Milestone Pharmaceuticals Inc. (MIST) and Microsoft Corporation (MSFT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	MIST	MSFT	Difference
Sharpe ratio: Return per unit of total volatility	-0.27	-0.87	+0.60
Sortino ratio: Return per unit of downside risk	0.19	-1.10	+1.29
Omega ratio: Gain probability vs. loss probability	1.03	0.86	+0.17
Calmar ratio: Return relative to maximum drawdown	-0.34	-0.66	+0.32
Martin ratio: Return relative to average drawdown	-0.63	-1.32	+0.69

MIST vs. MSFT - Sharpe Ratio Comparison

The current MIST Sharpe Ratio is -0.27, which is higher than the MSFT Sharpe Ratio of -0.87. The chart below compares the historical Sharpe Ratios of MIST and MSFT, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

MIST vs. MSFT - Drawdown Comparison

The maximum MIST drawdown since its inception was -97.60%, which is greater than MSFT's maximum drawdown of -69.38%. Use the drawdown chart below to compare losses from any high point for MIST and MSFT.

Drawdown Indicators

	MIST	MSFT	Difference
Max Drawdown Largest peak-to-trough decline	-97.60%	-69.38%	-28.22%
Max Drawdown (1Y) Largest decline over 1 year	-65.76%	-33.91%	-31.85%
Max Drawdown (3Y) Largest decline over 3 years	-82.31%	-33.91%	-48.40%
Max Drawdown (5Y) Largest decline over 5 years	-93.13%	-37.15%	-55.98%
Max Drawdown (10Y) Largest decline over 10 years	—	-37.15%	—
Current Drawdown Current decline from peak	-95.17%	-31.80%	-63.37%
Average Drawdown Average peak-to-trough decline	-78.34%	-21.79%	-56.55%
Ulcer Index Depth and duration of drawdowns from previous peaks	35.63%	16.97%	+18.66%

Volatility

MIST vs. MSFT - Volatility Comparison

Milestone Pharmaceuticals Inc. (MIST) has a higher volatility of 12.76% compared to Microsoft Corporation (MSFT) at 11.08%. This indicates that MIST's price experiences larger fluctuations and is considered to be riskier than MSFT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MIST	MSFT	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.76%	11.08%	+1.68%
Volatility (6M) Calculated over the trailing 6-month period	54.45%	22.93%	+31.52%
Volatility (1Y) Calculated over the trailing 1-year period	83.41%	26.01%	+57.40%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	77.73%	26.78%	+50.95%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	105.01%	27.11%	+77.90%

Dividends

MIST vs. MSFT - Dividend Comparison

MIST has not paid dividends to shareholders, while MSFT's dividend yield for the trailing twelve months is around 0.97%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
MIST Milestone Pharmaceuticals Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
MSFT Microsoft Corporation	0.97%	0.70%	0.73%	0.74%	1.06%	0.68%	0.94%	1.20%	1.69%	1.86%	2.37%	2.33%

Financials

Frequently Asked Questions

Can I hold both MIST and MSFT in my portfolio?

MIST and MSFT have a correlation of 0.17, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, MIST or MSFT?

MIST has higher volatility (12.76%) compared to MSFT (11.08%). In terms of maximum drawdown, MIST dropped -97.60% vs MSFT's -69.38%.

Which has better risk-adjusted returns?

MIST currently has the higher Sharpe Ratio (-0.27 vs -0.87), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.