KRRO vs. PRAX

Last updated Apr 1, 2026

Compare and contrast key facts about Frequency Therapeutics Inc (KRRO) and Praxis Precision Medicines, Inc. (PRAX).

Performance

KRRO vs. PRAX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Frequency Therapeutics Inc (KRRO) and Praxis Precision Medicines, Inc. (PRAX). The values are adjusted to include any dividend payments, if applicable.

KRRO vs. PRAX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
KRRO Frequency Therapeutics Inc	41.32%	-78.96%	-20.57%	209.63%
PRAX Praxis Precision Medicines, Inc.	9.31%	282.98%	245.42%	50.67%

Fundamentals

Market Cap KRRO : $106.36M PRAX : $7.25B
EPS KRRO : -$12.48 PRAX : -$13.79
PB Ratio KRRO : 2.07 PRAX : 8.26
Total Revenue (TTM) KRRO : $6.39M PRAX : $0.00
Gross Profit (TTM) KRRO : $5.10M PRAX : $0.00
EBITDA (TTM) KRRO : -$117.05M PRAX : -$326.20M

Returns By Period

In the year-to-date period, KRRO achieves a 41.32% return, which is significantly higher than PRAX's 9.31% return.

KRRO

• 1D: 10.12%
• 1M: -6.68%
• YTD: 41.32%
• 6M: -76.36%
• 1Y: -34.98%
• 3Y*: —
• 5Y*: —
• 10Y*: —

PRAX

• 1D: 16.55%
• 1M: -4.32%
• YTD: 9.31%
• 6M: 507.91%
• 1Y: 750.78%
• 3Y*: 198.33%
• 5Y*: -6.98%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

KRRO vs. PRAX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

KRRO

KRRO Risk / Return Rank: 39
KRRO Sharpe Ratio Rank: 28
KRRO Sortino Ratio Rank: 51
KRRO Omega Ratio Rank: 56
KRRO Calmar Ratio Rank: 29
KRRO Martin Ratio Rank: 31

PRAX

PRAX Risk / Return Rank: 99
PRAX Sharpe Ratio Rank: 98
PRAX Sortino Ratio Rank: 99
PRAX Omega Ratio Rank: 99
PRAX Calmar Ratio Rank: 100
PRAX Martin Ratio Rank: 100

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

KRRO vs. PRAX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Frequency Therapeutics Inc (KRRO) and Praxis Precision Medicines, Inc. (PRAX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	KRRO	PRAX	Difference
Sharpe ratio Return per unit of total volatility	-0.27	3.82	-4.09
Sortino ratio Return per unit of downside risk	0.86	7.55	-6.69
Omega ratio Gain probability vs. loss probability	1.14	1.92	-0.78
Calmar ratio Return relative to maximum drawdown	-0.39	20.19	-20.58
Martin ratio Return relative to average drawdown	-0.65	61.41	-62.06
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

KRRO vs. PRAX - Sharpe Ratio Comparison

The current KRRO Sharpe Ratio is -0.27, which is lower than the PRAX Sharpe Ratio of 3.82. The chart below compares the historical Sharpe Ratios of KRRO and PRAX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	KRRO	PRAX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.27	3.82	-4.09
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.05	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.09	-0.04	-0.05

Correlation

The correlation between KRRO and PRAX is 0.24, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

KRRO vs. PRAX - Dividend Comparison

Neither KRRO nor PRAX has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

KRRO vs. PRAX - Drawdown Comparison

The maximum KRRO drawdown since its inception was -94.13%, roughly equal to the maximum PRAX drawdown of -98.67%. Use the drawdown chart below to compare losses from any high point for KRRO and PRAX.

Drawdown Indicators

	KRRO	PRAX	Difference
Max Drawdown Largest peak-to-trough decline	-94.13%	-98.67%	+4.54%
Max Drawdown (1Y) Largest decline over 1 year	-89.72%	-36.33%	-53.39%
Max Drawdown (5Y) Largest decline over 5 years	—	-97.57%	—
Current Drawdown Current decline from peak	-87.42%	-64.32%	-23.10%
Average Drawdown Average peak-to-trough decline	-57.12%	-81.22%	+24.10%
Ulcer Index Depth and duration of drawdowns from previous peaks	53.61%	11.94%	+41.67%

Volatility

KRRO vs. PRAX - Volatility Comparison

Frequency Therapeutics Inc (KRRO) has a higher volatility of 25.17% compared to Praxis Precision Medicines, Inc. (PRAX) at 21.48%. This indicates that KRRO's price experiences larger fluctuations and is considered to be riskier than PRAX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	KRRO	PRAX	Difference
Volatility (1M) Calculated over the trailing 1-month period	25.17%	21.48%	+3.69%
Volatility (6M) Calculated over the trailing 6-month period	169.84%	118.54%	+51.30%
Volatility (1Y) Calculated over the trailing 1-year period	129.21%	198.37%	-69.16%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	138.54%	128.56%	+9.98%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	138.54%	125.48%	+13.06%

Financials