KRRO vs. PRAX

Last updated Jun 4, 2026

KRRO (Frequency Therapeutics Inc) and PRAX (Praxis Precision Medicines, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past year, KRRO returned -7.12% vs 577.01% for PRAX. At a 0.24 correlation, their price movements are largely independent.

Performance

KRRO vs. PRAX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Frequency Therapeutics Inc (KRRO) and Praxis Precision Medicines, Inc. (PRAX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, KRRO achieves a 38.33% return, which is significantly higher than PRAX's -5.36% return.

KRRO

• 1D: 0.73%
• 1M: -14.97%
• YTD: 38.33%
• 6M: 83.44%
• 1Y: -7.12%
• 3Y*: —
• 5Y*: —
• 10Y*: —

PRAX

• 1D: 8.08%
• 1M: -17.38%
• YTD: -5.36%
• 6M: 49.84%
• 1Y: 577.01%
• 3Y*: 164.05%
• 5Y*: -0.71%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

KRRO vs. PRAX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
KRRO Frequency Therapeutics Inc	38.33%	-78.96%	-20.57%	209.63%
PRAX Praxis Precision Medicines, Inc.	-5.36%	282.98%	245.42%	50.67%

Correlation

The correlation between KRRO and PRAX is 0.26, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.26
Correlation (All Time) Calculated using the full available price history since Nov 7, 2023	0.24

Fundamentals

Market Cap KRRO : $128.51M PRAX : $8.06B
EPS KRRO : -$11.41 PRAX : -$13.77
PB Ratio KRRO : 1.07 PRAX : 5.71
Total Revenue (TTM) KRRO : $3.84M PRAX : -$92.00K
Gross Profit (TTM) KRRO : $3.19M PRAX : -$128.83M
EBITDA (TTM) KRRO : -$78.53M PRAX : -$344.68M

Return for Risk

KRRO vs. PRAX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

KRRO

KRRO Risk / Return Rank: 48
KRRO Sharpe Ratio Rank: 39
KRRO Sortino Ratio Rank: 59
KRRO Omega Ratio Rank: 67
KRRO Calmar Ratio Rank: 38
KRRO Martin Ratio Rank: 39

PRAX

PRAX Risk / Return Rank: 98
PRAX Sharpe Ratio Rank: 94
PRAX Sortino Ratio Rank: 99
PRAX Omega Ratio Rank: 98
PRAX Calmar Ratio Rank: 99
PRAX Martin Ratio Rank: 99

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

KRRO vs. PRAX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Frequency Therapeutics Inc (KRRO) and Praxis Precision Medicines, Inc. (PRAX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	KRRO	PRAX	Difference
Sharpe ratio Return per unit of total volatility	-0.06	2.93	-2.99
Sortino ratio Return per unit of downside risk	1.21	6.64	-5.43
Omega ratio Gain probability vs. loss probability	1.20	1.86	-0.66
Calmar ratio Return relative to maximum drawdown	-0.08	16.02	-16.10
Martin ratio Return relative to average drawdown	-0.12	50.51	-50.63
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

KRRO vs. PRAX - Sharpe Ratio Comparison

The current KRRO Sharpe Ratio is -0.06, which is lower than the PRAX Sharpe Ratio of 2.93. The chart below compares the historical Sharpe Ratios of KRRO and PRAX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	KRRO	PRAX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.06	2.93	-2.99
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.01	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.09	-0.06	-0.03

Drawdowns

KRRO vs. PRAX - Drawdown Comparison

The maximum KRRO drawdown since its inception was -94.13%, roughly equal to the maximum PRAX drawdown of -98.67%. Use the drawdown chart below to compare losses from any high point for KRRO and PRAX.

Drawdown Indicators

	KRRO	PRAX	Difference
Max Drawdown Largest peak-to-trough decline	-94.13%	-98.67%	+4.54%
Max Drawdown (1Y) Largest decline over 1 year	-89.72%	-36.33%	-53.39%
Max Drawdown (3Y) Largest decline over 3 years	—	-68.64%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-96.50%	—
Current Drawdown Current decline from peak	-87.69%	-69.11%	-18.58%
Average Drawdown Average peak-to-trough decline	-59.09%	-80.66%	+21.57%
Ulcer Index Depth and duration of drawdowns from previous peaks	59.78%	11.50%	+48.28%

Volatility

KRRO vs. PRAX - Volatility Comparison

Frequency Therapeutics Inc (KRRO) and Praxis Precision Medicines, Inc. (PRAX) have volatilities of 31.24% and 30.10%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	KRRO	PRAX	Difference
Volatility (1M) Calculated over the trailing 1-month period	31.24%	30.10%	+1.14%
Volatility (6M) Calculated over the trailing 6-month period	59.32%	54.82%	+4.50%
Volatility (1Y) Calculated over the trailing 1-year period	124.96%	198.58%	-73.62%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	135.87%	127.54%	+8.33%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	135.87%	124.23%	+11.64%

Dividends

KRRO vs. PRAX - Dividend Comparison

Neither KRRO nor PRAX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both KRRO and PRAX in my portfolio?

KRRO and PRAX have a correlation of 0.26, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, KRRO or PRAX?

KRRO has higher volatility (31.24%) compared to PRAX (30.10%). In terms of maximum drawdown, KRRO dropped -94.13% vs PRAX's -98.67%.

Which has better risk-adjusted returns?

PRAX currently has the higher Sharpe Ratio (2.93 vs -0.06), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.