JNGLX vs. FIJYX

Last updated Apr 2, 2026

Compare and contrast key facts about Janus Henderson Global Life Sciences Fund (JNGLX) and Fidelity Advisor Biotechnology Fund Class Z (FIJYX).

JNGLX is managed by Janus Henderson. It was launched on Dec 30, 1998. FIJYX is managed by Fidelity. It was launched on Oct 2, 2018.

Performance

JNGLX vs. FIJYX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Global Life Sciences Fund (JNGLX) and Fidelity Advisor Biotechnology Fund Class Z (FIJYX). The values are adjusted to include any dividend payments, if applicable.

JNGLX vs. FIJYX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
JNGLX Janus Henderson Global Life Sciences Fund	-3.73%	24.84%	3.60%	7.51%	-2.69%	6.78%	25.66%	29.20%	-9.63%
FIJYX Fidelity Advisor Biotechnology Fund Class Z	2.35%	40.09%	0.03%	11.19%	-7.60%	-2.76%	32.72%	26.25%	-11.45%

Returns By Period

In the year-to-date period, JNGLX achieves a -3.73% return, which is significantly lower than FIJYX's 2.35% return.

JNGLX

• 1D: 3.08%
• 1M: -5.55%
• YTD: -3.73%
• 6M: 11.88%
• 1Y: 21.71%
• 3Y*: 10.69%
• 5Y*: 7.33%
• 10Y*: 11.02%

FIJYX

• 1D: 5.06%
• 1M: -0.73%
• YTD: 2.35%
• 6M: 15.76%
• 1Y: 55.98%
• 3Y*: 18.69%
• 5Y*: 8.12%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

JNGLX vs. FIJYX - Expense Ratio Comparison

JNGLX has a 0.80% expense ratio, which is higher than FIJYX's 0.61% expense ratio.

JNGLX

Janus Henderson Global Life Sciences Fund

FIJYX

Fidelity Advisor Biotechnology Fund Class Z

Return for Risk

JNGLX vs. FIJYX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JNGLX

JNGLX Risk / Return Rank: 55
JNGLX Sharpe Ratio Rank: 55
JNGLX Sortino Ratio Rank: 54
JNGLX Omega Ratio Rank: 44
JNGLX Calmar Ratio Rank: 73
JNGLX Martin Ratio Rank: 47

FIJYX

FIJYX Risk / Return Rank: 89
FIJYX Sharpe Ratio Rank: 90
FIJYX Sortino Ratio Rank: 88
FIJYX Omega Ratio Rank: 80
FIJYX Calmar Ratio Rank: 94
FIJYX Martin Ratio Rank: 94

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JNGLX vs. FIJYX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Global Life Sciences Fund (JNGLX) and Fidelity Advisor Biotechnology Fund Class Z (FIJYX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	JNGLX	FIJYX	Difference
Sharpe ratio Return per unit of total volatility	1.07	1.96	-0.89
Sortino ratio Return per unit of downside risk	1.54	2.56	-1.02
Omega ratio Gain probability vs. loss probability	1.20	1.33	-0.13
Calmar ratio Return relative to maximum drawdown	1.80	3.20	-1.40
Martin ratio Return relative to average drawdown	4.97	12.85	-7.87
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

JNGLX vs. FIJYX - Sharpe Ratio Comparison

The current JNGLX Sharpe Ratio is 1.07, which is lower than the FIJYX Sharpe Ratio of 1.96. The chart below compares the historical Sharpe Ratios of JNGLX and FIJYX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	JNGLX	FIJYX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.07	1.96	-0.89
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.47	0.35	+0.12
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.63	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.57	0.43	+0.14

Correlation

The correlation between JNGLX and FIJYX is 0.86, which is considered to be high. That indicates a strong positive relationship between their price movements. Having highly-correlated positions in a portfolio may signal a lack of diversification, potentially leading to increased risk during market downturns.

Dividends

JNGLX vs. FIJYX - Dividend Comparison

JNGLX's dividend yield for the trailing twelve months is around 4.74%, more than FIJYX's 1.41% yield.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JNGLX Janus Henderson Global Life Sciences Fund	4.74%	4.56%	5.84%	4.26%	0.25%	9.85%	7.80%	6.23%	13.32%	0.89%	0.30%	8.81%
FIJYX Fidelity Advisor Biotechnology Fund Class Z	1.41%	1.44%	0.00%	1.55%	0.00%	18.90%	8.13%	6.49%	2.35%	0.00%	0.00%	0.00%

Drawdowns

JNGLX vs. FIJYX - Drawdown Comparison

The maximum JNGLX drawdown since its inception was -59.00%, which is greater than FIJYX's maximum drawdown of -38.53%. Use the drawdown chart below to compare losses from any high point for JNGLX and FIJYX.

Drawdown Indicators

	JNGLX	FIJYX	Difference
Max Drawdown Largest peak-to-trough decline	-59.00%	-38.53%	-20.47%
Max Drawdown (1Y) Largest decline over 1 year	-9.68%	-13.59%	+3.91%
Max Drawdown (5Y) Largest decline over 5 years	-22.21%	-36.39%	+14.18%
Max Drawdown (10Y) Largest decline over 10 years	-27.37%	—	—
Current Drawdown Current decline from peak	-6.62%	-2.49%	-4.13%
Average Drawdown Average peak-to-trough decline	-17.73%	-11.76%	-5.97%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.61%	3.69%	-0.08%

Volatility

JNGLX vs. FIJYX - Volatility Comparison

The current volatility for Janus Henderson Global Life Sciences Fund (JNGLX) is 5.98%, while Fidelity Advisor Biotechnology Fund Class Z (FIJYX) has a volatility of 9.34%. This indicates that JNGLX experiences smaller price fluctuations and is considered to be less risky than FIJYX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JNGLX	FIJYX	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.98%	9.34%	-3.36%
Volatility (6M) Calculated over the trailing 6-month period	10.63%	17.01%	-6.38%
Volatility (1Y) Calculated over the trailing 1-year period	17.86%	26.00%	-8.14%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	15.69%	23.43%	-7.74%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	17.42%	25.07%	-7.65%