JFRDX vs. JNGLX

Last updated Jun 24, 2026

JFRDX (Janus Henderson Forty Fund Class D) and JNGLX (Janus Henderson Global Life Sciences Fund) are both mutual funds - JFRDX is a Large Cap Growth Equities fund actively managed by Janus Henderson, while JNGLX is a Health & Biotech Equities fund managed by Janus Henderson. Over the past 5 years, JFRDX returned 9.50%/yr vs 7.47%/yr for JNGLX. A 0.65 correlation means they provide meaningful diversification when combined. JFRDX charges 0.63%/yr vs 0.80%/yr for JNGLX.

Performance

JFRDX vs. JNGLX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Forty Fund Class D (JFRDX) and Janus Henderson Global Life Sciences Fund (JNGLX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JFRDX achieves a 3.85% return, which is significantly higher than JNGLX's 2.46% return.

JFRDX

• 1D: -1.41%
• 1M: -0.05%
• YTD: 3.85%
• 6M: 2.98%
• 1Y: 18.47%
• 3Y*: 21.23%
• 5Y*: 9.50%
• 10Y*: —

JNGLX

• 1D: 1.87%
• 1M: 2.60%
• YTD: 2.46%
• 6M: 1.98%
• 1Y: 33.35%
• 3Y*: 11.29%
• 5Y*: 7.47%
• 10Y*: 11.69%

*Multi-year figures are annualized to reflect compound growth (CAGR)

JFRDX vs. JNGLX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JFRDX Janus Henderson Forty Fund Class D	3.85%	18.31%	28.26%	40.01%	-33.58%	22.73%	39.22%	36.75%	1.49%	16.74%
JNGLX Janus Henderson Global Life Sciences Fund	2.46%	24.84%	3.60%	7.51%	-2.69%	6.78%	25.66%	29.20%	4.17%	17.54%

Correlation

The correlation between JFRDX and JNGLX is 0.29, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.29
Correlation (3Y) Calculated over the trailing 3-year period	0.45
Correlation (5Y) Calculated over the trailing 5-year period	0.58
Correlation (All Time) Calculated using the full available price history since Feb 1, 2017	0.65

Over the past year, the correlation between JFRDX and JNGLX has dropped to 0.29 - well below their long-term average of 0.65, suggesting their price drivers have been diverging.

Return for Risk

JFRDX vs. JNGLX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JFRDX

JFRDX Risk / Return Rank: 14
JFRDX Sharpe Ratio Rank: 16
JFRDX Sortino Ratio Rank: 15
JFRDX Omega Ratio Rank: 15
JFRDX Calmar Ratio Rank: 11
JFRDX Martin Ratio Rank: 12

JNGLX

JNGLX Risk / Return Rank: 68
JNGLX Sharpe Ratio Rank: 69
JNGLX Sortino Ratio Rank: 72
JNGLX Omega Ratio Rank: 59
JNGLX Calmar Ratio Rank: 81
JNGLX Martin Ratio Rank: 59

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JFRDX vs. JNGLX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Forty Fund Class D (JFRDX) and Janus Henderson Global Life Sciences Fund (JNGLX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	JFRDX	JNGLX	Difference
Sharpe ratio: Return per unit of total volatility	1.05	2.22	-1.17
Sortino ratio: Return per unit of downside risk	1.51	3.23	-1.72
Omega ratio: Gain probability vs. loss probability	1.19	1.39	-0.20
Calmar ratio: Return relative to maximum drawdown	1.03	3.49	-2.47
Martin ratio: Return relative to average drawdown	3.30	11.13	-7.83

JFRDX vs. JNGLX - Sharpe Ratio Comparison

The current JFRDX Sharpe Ratio is 1.05, which is lower than the JNGLX Sharpe Ratio of 2.22. The chart below compares the historical Sharpe Ratios of JFRDX and JNGLX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

JFRDX vs. JNGLX - Drawdown Comparison

The maximum JFRDX drawdown since its inception was -40.91%, smaller than the maximum JNGLX drawdown of -59.00%. Use the drawdown chart below to compare losses from any high point for JFRDX and JNGLX.

Drawdown Indicators

	JFRDX	JNGLX	Difference
Max Drawdown Largest peak-to-trough decline	-40.91%	-59.00%	+18.09%
Max Drawdown (1Y) Largest decline over 1 year	-19.05%	-9.68%	-9.37%
Max Drawdown (3Y) Largest decline over 3 years	-22.14%	-21.17%	-0.97%
Max Drawdown (5Y) Largest decline over 5 years	-40.91%	-22.21%	-18.70%
Max Drawdown (10Y) Largest decline over 10 years	—	-27.37%	—
Current Drawdown Current decline from peak	-4.69%	-0.62%	-4.07%
Average Drawdown Average peak-to-trough decline	-8.15%	-17.62%	+9.47%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.92%	3.03%	+2.89%

Volatility

JFRDX vs. JNGLX - Volatility Comparison

Janus Henderson Forty Fund Class D (JFRDX) has a higher volatility of 7.59% compared to Janus Henderson Global Life Sciences Fund (JNGLX) at 5.62%. This indicates that JFRDX's price experiences larger fluctuations and is considered to be riskier than JNGLX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JFRDX	JNGLX	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.59%	5.62%	+1.97%
Volatility (6M) Calculated over the trailing 6-month period	14.80%	11.38%	+3.42%
Volatility (1Y) Calculated over the trailing 1-year period	18.60%	15.26%	+3.34%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	22.19%	15.93%	+6.26%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	22.10%	17.41%	+4.69%

JFRDX vs. JNGLX - Expense Ratio Comparison

JFRDX has a 0.63% expense ratio, which is lower than JNGLX's 0.80% expense ratio.

Dividends

JFRDX vs. JNGLX - Dividend Comparison

JFRDX's dividend yield for the trailing twelve months is around 12.61%, more than JNGLX's 4.45% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JFRDX Janus Henderson Forty Fund Class D	12.61%	13.10%	11.27%	9.12%	0.06%	10.12%	8.26%	7.21%	8.88%	9.68%	0.00%	0.00%
JNGLX Janus Henderson Global Life Sciences Fund	4.45%	4.56%	5.84%	4.26%	0.25%	9.85%	7.80%	6.23%	13.32%	0.89%	0.30%	8.81%

Frequently Asked Questions

Can I hold both JFRDX and JNGLX in my portfolio?

JFRDX and JNGLX have a correlation of 0.29, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JFRDX or JNGLX?

JFRDX has higher volatility (7.59%) compared to JNGLX (5.62%). In terms of maximum drawdown, JFRDX dropped -40.91% vs JNGLX's -59.00%.

Which has better risk-adjusted returns?

JNGLX currently has the higher Sharpe Ratio (2.22 vs 1.05), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.