JBIO vs. CRSP

Last updated Aug 1, 2026

JBIO (Jade Biosciences, Inc) and CRSP (CRISPR Therapeutics AG) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, JBIO returned 71.21%/yr vs -16.89%/yr for CRSP. Their 0.29 correlation means their historical movements had little consistent relationship.

Performance

JBIO vs. CRSP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Jade Biosciences, Inc (JBIO) and CRISPR Therapeutics AG (CRSP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JBIO achieves a 28.00% return, which is significantly higher than CRSP's -8.49% return.

JBIO

• 1D: -1.25%
• 1M: -8.18%
• 6M: 26.52%
• YTD: 28.00%
• 1Y: 186.65%
• 3Y*: 124.22%
• 5Y*: 71.21%
• 10Y*: —
• ALL TIME*: 45.59%

CRSP

• 1D: -0.93%
• 1M: -20.12%
• 6M: -3.94%
• YTD: -8.49%
• 1Y: -14.44%
• 3Y*: -5.25%
• 5Y*: -16.89%
• 10Y*: —
• ALL TIME*: 12.63%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
CRSP CRISPR Therapeutics AG	$77.21M	$89.27M	$90.29M
JBIO Jade Biosciences, Inc	$14.42M	$18.92M	$20.53M

JBIO vs. CRSP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
JBIO Jade Biosciences, Inc	28.00%	5,473.10%	-88.29%	-22.76%	148.52%	-57.89%
CRSP CRISPR Therapeutics AG	-8.49%	33.23%	-37.12%	54.00%	-46.36%	-49.64%

Correlation

The correlation between JBIO and CRSP is 0.34, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.34
Correlation (3Y) Balances recent behavior with more history.	0.32
Correlation (5Y) Shows whether the relationship held over a longer period.	0.29
Correlation (All Time) Calculated using the full available price history since Jun 30, 2021	0.29

Fundamentals

Market Cap JBIO : $644.36M CRSP : $4.63B
EPS JBIO : -$2.65 CRSP : -$6.15
PB Ratio JBIO : 3.85 CRSP : 2.54
Total Revenue (TTM) JBIO : $0.00 CRSP : $4.10M
Gross Profit (TTM) JBIO : -$9.00K CRSP : -$171.17M
EBITDA (TTM) JBIO : -$133.57M CRSP : -$509.21M

Return for Risk

JBIO vs. CRSP — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

JBIO

JBIO Risk / Return Rank: 92
JBIO Sharpe Ratio Rank: 94
JBIO Sortino Ratio Rank: 91
JBIO Omega Ratio Rank: 88
JBIO Calmar Ratio Rank: 92
JBIO Martin Ratio Rank: 93

CRSP

CRSP Risk / Return Rank: 34
CRSP Sharpe Ratio Rank: 33
CRSP Sortino Ratio Rank: 34
CRSP Omega Ratio Rank: 34
CRSP Calmar Ratio Rank: 33
CRSP Martin Ratio Rank: 35

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

JBIO vs. CRSP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Jade Biosciences, Inc (JBIO) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	JBIO	CRSP	Difference
Sharpe ratio: Return per unit of total volatility	2.33	-0.25	+2.58
Sortino ratio: Return per unit of downside risk	2.82	0.03	+2.79
Omega ratio: Gain probability vs. loss probability	1.34	1.00	+0.34
Calmar ratio: Return relative to maximum drawdown	3.98	-0.35	+4.33
Martin ratio: Return relative to average drawdown	11.49	-0.54	+12.03

JBIO vs. CRSP - Sharpe Ratio Comparison

The current JBIO Sharpe Ratio is 2.33, which is higher than the CRSP Sharpe Ratio of -0.25. The chart below compares the historical Sharpe Ratios of JBIO and CRSP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

JBIO vs. CRSP - Drawdown Comparison

The maximum JBIO drawdown since its inception was -95.41%, which is greater than CRSP's maximum drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for JBIO and CRSP.

Drawdown Indicators

	JBIO	CRSP	Difference
Max Drawdown Largest peak-to-trough decline	-95.41%	-85.11%	-10.30%
Max Drawdown (1Y) Largest decline over 1 year	-44.21%	-42.25%	-1.96%
Max Drawdown (3Y) Largest decline over 3 years	-95.41%	-64.91%	-30.50%
Max Drawdown (5Y) Largest decline over 5 years	-95.41%	-77.31%	-18.10%
Current Drawdown Current decline from peak	-26.44%	-77.15%	+50.71%
Average Drawdown Average peak-to-trough decline	-44.62%	-49.59%	+4.97%
Ulcer Index Depth and duration of drawdowns from previous peaks	15.27%	27.26%	-11.99%

Volatility

JBIO vs. CRSP - Volatility Comparison

Jade Biosciences, Inc (JBIO) and CRISPR Therapeutics AG (CRSP) have volatilities of 15.16% and 14.89%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JBIO	CRSP	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.16%	14.89%	+0.27%
Volatility (6M) Calculated over the trailing 6-month period	54.20%	42.58%	+11.62%
Volatility (1Y) Calculated over the trailing 1-year period	75.63%	58.68%	+16.95%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	1,580.65%	60.64%	+1,520.01%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	1,567.07%	64.15%	+1,502.92%

Dividends

JBIO vs. CRSP - Dividend Comparison

Neither JBIO nor CRSP has paid dividends to shareholders.

Position	TTM	2025
CRSP CRISPR Therapeutics AG	0.00%	0.00%
JBIO Jade Biosciences, Inc	0.00%	15.55%

Financials

Frequently Asked Questions

Can I hold both JBIO and CRSP in my portfolio?

JBIO and CRSP have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JBIO or CRSP?

JBIO has higher volatility (15.16%) compared to CRSP (14.89%). In terms of maximum drawdown, JBIO dropped -95.41% vs CRSP's -85.11%.

Which has better risk-adjusted returns?

JBIO currently has the higher Sharpe Ratio (2.33 vs -0.25), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.