JARTX vs. JAGLX

Last updated Jun 23, 2026

JARTX (Janus Henderson Forty Fund) and JAGLX (Janus Henderson Global Life Sciences Fund Class T) are both mutual funds - JARTX is a Large Cap Growth Equities fund managed by Janus Henderson, while JAGLX is a Health & Biotech Equities fund actively managed by Janus Henderson. Over the past 10 years, JARTX returned 16.41%/yr vs 11.69%/yr for JAGLX. A 0.72 correlation means they provide meaningful diversification when combined. JARTX charges 1.20%/yr vs 0.92%/yr for JAGLX.

Performance

JARTX vs. JAGLX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Forty Fund (JARTX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JARTX achieves a 5.17% return, which is significantly higher than JAGLX's 0.53% return. Over the past 10 years, JARTX has outperformed JAGLX with an annualized return of 16.41%, while JAGLX has yielded a comparatively lower 11.69% annualized return.

JARTX

• 1D: 1.65%
• 1M: 1.36%
• YTD: 5.17%
• 6M: 5.05%
• 1Y: 20.74%
• 3Y*: 20.92%
• 5Y*: 9.80%
• 10Y*: 16.41%

JAGLX

• 1D: -0.39%
• 1M: 0.72%
• YTD: 0.53%
• 6M: 0.00%
• 1Y: 31.08%
• 3Y*: 11.89%
• 5Y*: 8.09%
• 10Y*: 11.69%

*Multi-year figures are annualized to reflect compound growth (CAGR)

JARTX vs. JAGLX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JARTX Janus Henderson Forty Fund	5.17%	17.88%	27.76%	39.50%	-33.81%	22.30%	38.69%	36.30%	1.10%	29.05%
JAGLX Janus Henderson Global Life Sciences Fund Class T	0.53%	24.72%	8.50%	7.41%	-2.79%	6.66%	25.52%	29.12%	4.05%	22.13%

Correlation

The correlation between JARTX and JAGLX is 0.30, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.30
Correlation (3Y) Calculated over the trailing 3-year period	0.45
Correlation (5Y) Calculated over the trailing 5-year period	0.58
Correlation (10Y) Calculated over the trailing 10-year period	0.65
Correlation (All Time) Calculated using the full available price history since Dec 31, 1998	0.72

Over the past year, the correlation between JARTX and JAGLX has dropped to 0.30 - well below their long-term average of 0.72, suggesting their price drivers have been diverging.

Return for Risk

JARTX vs. JAGLX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JARTX

JARTX Risk / Return Rank: 14
JARTX Sharpe Ratio Rank: 16
JARTX Sortino Ratio Rank: 16
JARTX Omega Ratio Rank: 16
JARTX Calmar Ratio Rank: 12
JARTX Martin Ratio Rank: 12

JAGLX

JAGLX Risk / Return Rank: 59
JAGLX Sharpe Ratio Rank: 56
JAGLX Sortino Ratio Rank: 60
JAGLX Omega Ratio Rank: 50
JAGLX Calmar Ratio Rank: 73
JAGLX Martin Ratio Rank: 53

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JARTX vs. JAGLX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Forty Fund (JARTX) and Janus Henderson Global Life Sciences Fund Class T (JAGLX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	JARTX	JAGLX	Difference
Sharpe ratio: Return per unit of total volatility	1.08	2.03	-0.96
Sortino ratio: Return per unit of downside risk	1.54	2.98	-1.44
Omega ratio: Gain probability vs. loss probability	1.19	1.36	-0.16
Calmar ratio: Return relative to maximum drawdown	1.04	3.17	-2.13
Martin ratio: Return relative to average drawdown	3.34	10.08	-6.74

JARTX vs. JAGLX - Sharpe Ratio Comparison

The current JARTX Sharpe Ratio is 1.08, which is lower than the JAGLX Sharpe Ratio of 2.03. The chart below compares the historical Sharpe Ratios of JARTX and JAGLX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

JARTX vs. JAGLX - Drawdown Comparison

The maximum JARTX drawdown since its inception was -56.70%, roughly equal to the maximum JAGLX drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for JARTX and JAGLX.

Drawdown Indicators

	JARTX	JAGLX	Difference
Max Drawdown Largest peak-to-trough decline	-56.70%	-58.96%	+2.26%
Max Drawdown (1Y) Largest decline over 1 year	-19.19%	-9.71%	-9.48%
Max Drawdown (3Y) Largest decline over 3 years	-22.22%	-17.41%	-4.81%
Max Drawdown (5Y) Largest decline over 5 years	-41.09%	-22.25%	-18.84%
Max Drawdown (10Y) Largest decline over 10 years	-41.09%	-27.38%	-13.71%
Current Drawdown Current decline from peak	-3.33%	-2.48%	-0.85%
Average Drawdown Average peak-to-trough decline	-16.81%	-17.40%	+0.59%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.97%	3.05%	+2.92%

Volatility

JARTX vs. JAGLX - Volatility Comparison

Janus Henderson Forty Fund (JARTX) has a higher volatility of 7.54% compared to Janus Henderson Global Life Sciences Fund Class T (JAGLX) at 5.38%. This indicates that JARTX's price experiences larger fluctuations and is considered to be riskier than JAGLX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JARTX	JAGLX	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.54%	5.38%	+2.16%
Volatility (6M) Calculated over the trailing 6-month period	14.85%	11.25%	+3.60%
Volatility (1Y) Calculated over the trailing 1-year period	18.53%	15.13%	+3.40%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	22.17%	15.98%	+6.19%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	21.54%	17.42%	+4.12%

JARTX vs. JAGLX - Expense Ratio Comparison

JARTX has a 1.20% expense ratio, which is higher than JAGLX's 0.92% expense ratio.

Dividends

JARTX vs. JAGLX - Dividend Comparison

JARTX's dividend yield for the trailing twelve months is around 12.98%, more than JAGLX's 4.50% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JAGLX Janus Henderson Global Life Sciences Fund Class T	4.50%	4.53%	10.98%	4.22%	0.14%	9.78%	7.75%	6.17%	13.38%	0.89%	1.13%	9.09%
JARTX Janus Henderson Forty Fund	12.98%	13.65%	11.51%	9.10%	0.06%	10.26%	8.38%	7.05%	8.95%	14.50%	6.57%	15.93%

Frequently Asked Questions

Can I hold both JARTX and JAGLX in my portfolio?

JARTX and JAGLX have a correlation of 0.30, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JARTX or JAGLX?

JARTX has higher volatility (7.54%) compared to JAGLX (5.38%). In terms of maximum drawdown, JARTX dropped -56.70% vs JAGLX's -58.96%.

Which has better risk-adjusted returns?

JAGLX currently has the higher Sharpe Ratio (2.03 vs 1.08), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.