IRWD vs. IPSC

Last updated Jun 3, 2026

IRWD (Ironwood Pharmaceuticals, Inc.) and IPSC (Century Therapeutics, Inc.) are both stocks. Both are in the Healthcare sector — IRWD in Drug Manufacturers - Specialty & Generic, IPSC in Biotechnology. Over the past 3 years, IRWD returned -33.25%/yr vs -13.04%/yr for IPSC. At a 0.23 correlation, their price movements are largely independent.

Performance

IRWD vs. IPSC - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Ironwood Pharmaceuticals, Inc. (IRWD) and Century Therapeutics, Inc. (IPSC). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IRWD achieves a -2.67% return, which is significantly lower than IPSC's 118.13% return.

IRWD

• 1D: -5.20%
• 1M: -26.13%
• YTD: -2.67%
• 6M: -6.29%
• 1Y: 427.33%
• 3Y*: -33.25%
• 5Y*: -22.82%
• 10Y*: -12.83%

IPSC

• 1D: -8.05%
• 1M: -6.06%
• YTD: 118.13%
• 6M: 308.36%
• 1Y: 299.26%
• 3Y*: -13.04%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IRWD vs. IPSC - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
IRWD Ironwood Pharmaceuticals, Inc.	-2.67%	-23.93%	-61.28%	-7.67%	6.26%	-0.51%
IPSC Century Therapeutics, Inc.	118.13%	-1.50%	-69.58%	-35.28%	-67.65%	-30.53%

Correlation

The correlation between IRWD and IPSC is 0.21, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.21
Correlation (3Y) Calculated over the trailing 3-year period	0.23
Correlation (All Time) Calculated using the full available price history since Jun 21, 2021	0.23

Fundamentals

Market Cap IRWD : $546.74M IPSC : $419.84M
EPS IRWD : $0.88 IPSC : -$0.95
Total Revenue (TTM) IRWD : $361.51M IPSC : $0.00
Gross Profit (TTM) IRWD : $254.55M IPSC : -$9.88M
EBITDA (TTM) IRWD : $204.95M IPSC : -$103.02M

Return for Risk

IRWD vs. IPSC — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IRWD

IRWD Risk / Return Rank: 95
IRWD Sharpe Ratio Rank: 97
IRWD Sortino Ratio Rank: 94
IRWD Omega Ratio Rank: 90
IRWD Calmar Ratio Rank: 97
IRWD Martin Ratio Rank: 96

IPSC

IPSC Risk / Return Rank: 93
IPSC Sharpe Ratio Rank: 94
IPSC Sortino Ratio Rank: 92
IPSC Omega Ratio Rank: 90
IPSC Calmar Ratio Rank: 96
IPSC Martin Ratio Rank: 93

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IRWD vs. IPSC - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Ironwood Pharmaceuticals, Inc. (IRWD) and Century Therapeutics, Inc. (IPSC). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IRWD	IPSC	Difference
Sharpe ratio Return per unit of total volatility	3.96	3.07	+0.89
Sortino ratio Return per unit of downside risk	3.99	3.63	+0.36
Omega ratio Gain probability vs. loss probability	1.45	1.45	+0.01
Calmar ratio Return relative to maximum drawdown	10.26	8.36	+1.90
Martin ratio Return relative to average drawdown	24.22	16.63	+7.59
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IRWD vs. IPSC - Sharpe Ratio Comparison

The current IRWD Sharpe Ratio is 3.96, which is comparable to the IPSC Sharpe Ratio of 3.07. The chart below compares the historical Sharpe Ratios of IRWD and IPSC, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IRWD	IPSC	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	3.96	3.07	+0.89
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.31	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.21	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.13	-0.45	+0.32

Drawdowns

IRWD vs. IPSC - Drawdown Comparison

The maximum IRWD drawdown since its inception was -97.31%, roughly equal to the maximum IPSC drawdown of -98.78%. Use the drawdown chart below to compare losses from any high point for IRWD and IPSC.

Drawdown Indicators

	IRWD	IPSC	Difference
Max Drawdown Largest peak-to-trough decline	-97.31%	-98.78%	+1.47%
Max Drawdown (1Y) Largest decline over 1 year	-43.60%	-36.98%	-6.62%
Max Drawdown (3Y) Largest decline over 3 years	-96.33%	-92.68%	-3.65%
Max Drawdown (5Y) Largest decline over 5 years	-96.33%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-97.31%	—	—
Current Drawdown Current decline from peak	-84.43%	-93.20%	+8.77%
Average Drawdown Average peak-to-trough decline	-39.24%	-80.47%	+41.23%
Ulcer Index Depth and duration of drawdowns from previous peaks	18.48%	18.59%	-0.11%

Volatility

IRWD vs. IPSC - Volatility Comparison

Ironwood Pharmaceuticals, Inc. (IRWD) has a higher volatility of 22.28% compared to Century Therapeutics, Inc. (IPSC) at 17.14%. This indicates that IRWD's price experiences larger fluctuations and is considered to be riskier than IPSC based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IRWD	IPSC	Difference
Volatility (1M) Calculated over the trailing 1-month period	22.28%	17.14%	+5.14%
Volatility (6M) Calculated over the trailing 6-month period	60.67%	81.28%	-20.61%
Volatility (1Y) Calculated over the trailing 1-year period	108.88%	98.21%	+10.67%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	73.10%	84.04%	-10.94%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	60.94%	84.04%	-23.10%

Dividends

IRWD vs. IPSC - Dividend Comparison

Neither IRWD nor IPSC has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both IRWD and IPSC in my portfolio?

IRWD and IPSC have a correlation of 0.21, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IRWD or IPSC?

IRWD has higher volatility (22.28%) compared to IPSC (17.14%). In terms of maximum drawdown, IRWD dropped -97.31% vs IPSC's -98.78%.

Which has better risk-adjusted returns?

IRWD currently has the higher Sharpe Ratio (3.96 vs 3.07), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.