IOVA vs. AXSM
IOVA (Iovance Biotherapeutics, Inc.) and AXSM (Axsome Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, IOVA returned -6.39%/yr vs 42.66%/yr for AXSM. At a 0.28 correlation, their price movements are largely independent.
Performance
IOVA vs. AXSM - Performance Comparison
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Returns By Period
In the year-to-date period, IOVA achieves a 48.72% return, which is significantly higher than AXSM's 35.70% return. Over the past 10 years, IOVA has underperformed AXSM with an annualized return of -6.39%, while AXSM has yielded a comparatively higher 42.66% annualized return.
IOVA
- 1D
- 3.84%
- 1M
- -1.22%
- YTD
- 48.72%
- 6M
- 46.04%
- 1Y
- 105.05%
- 3Y*
- -20.47%
- 5Y*
- -30.33%
- 10Y*
- -6.39%
AXSM
- 1D
- -1.06%
- 1M
- 5.03%
- YTD
- 35.70%
- 6M
- 60.21%
- 1Y
- 146.15%
- 3Y*
- 41.16%
- 5Y*
- 28.89%
- 10Y*
- 42.66%
IOVA vs. AXSM - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
IOVA Iovance Biotherapeutics, Inc. | 48.72% | -63.11% | -8.98% | 27.23% | -66.53% | -58.86% | 67.63% | 212.77% | 10.62% | 15.11% |
AXSM Axsome Therapeutics, Inc. | 35.70% | 115.86% | 6.31% | 3.19% | 104.16% | -53.63% | -21.18% | 3,565.25% | -49.64% | -17.04% |
Correlation
The correlation between IOVA and AXSM is 0.31, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.31 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.33 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.34 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.29 |
Correlation (All Time) Calculated using the full available price history since Nov 19, 2015 | 0.28 |
Fundamentals
IOVA:
$1.70B
AXSM:
$12.69B
IOVA:
-$0.93
AXSM:
-$3.74
IOVA:
5.42
AXSM:
17.61
IOVA:
2.35
AXSM:
232.46
IOVA:
$285.61M
AXSM:
$708.24M
IOVA:
$327.04M
AXSM:
$655.82M
IOVA:
-$325.45M
AXSM:
-$172.72M
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Return for Risk
IOVA vs. AXSM — Risk / Return Rank
IOVA
AXSM
IOVA vs. AXSM - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Iovance Biotherapeutics, Inc. (IOVA) and Axsome Therapeutics, Inc. (AXSM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| IOVA | AXSM | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -2.49 | ||
| Sortino ratioReturn per unit of downside risk | -2.77 | ||
| Omega ratioGain probability vs. loss probability | 1.24 | 1.59 | -0.35 |
| Calmar ratioReturn relative to maximum drawdown | 1.94 | 7.95 | -6.01 |
| Martin ratioReturn relative to average drawdown | 3.05 | 23.42 | -20.36 |
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Drawdowns
IOVA vs. AXSM - Drawdown Comparison
The maximum IOVA drawdown since its inception was -99.37%, which is greater than AXSM's maximum drawdown of -86.65%. Use the drawdown chart below to compare losses from any high point for IOVA and AXSM.
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Drawdown Indicators
| IOVA | AXSM | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.37% | -86.65% | -12.72% |
Max Drawdown (1Y)Largest decline over 1 year | -54.41% | -18.50% | -35.91% |
Max Drawdown (3Y)Largest decline over 3 years | -90.50% | -34.83% | -55.67% |
Max Drawdown (5Y)Largest decline over 5 years | -93.99% | -72.91% | -21.08% |
Max Drawdown (10Y)Largest decline over 10 years | -96.84% | -81.26% | -15.58% |
Current DrawdownCurrent decline from peak | -97.45% | -2.87% | -94.58% |
Average DrawdownAverage peak-to-trough decline | -84.18% | -39.40% | -44.78% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 34.61% | 6.27% | +28.34% |
Volatility
IOVA vs. AXSM - Volatility Comparison
Iovance Biotherapeutics, Inc. (IOVA) has a higher volatility of 25.62% compared to Axsome Therapeutics, Inc. (AXSM) at 8.92%. This indicates that IOVA's price experiences larger fluctuations and is considered to be riskier than AXSM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| IOVA | AXSM | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 25.62% | 8.92% | +16.70% |
Volatility (6M)Calculated over the trailing 6-month period | 64.08% | 33.16% | +30.92% |
Volatility (1Y)Calculated over the trailing 1-year period | 101.54% | 41.74% | +59.80% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 89.88% | 70.26% | +19.62% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 81.44% | 90.40% | -8.96% |
Dividends
IOVA vs. AXSM - Dividend Comparison
Neither IOVA nor AXSM has paid dividends to shareholders.
Financials
IOVA vs. AXSM - Financials Comparison
This section allows you to compare key financial metrics between Iovance Biotherapeutics, Inc. and Axsome Therapeutics, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
IOVA and AXSM have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
IOVA has higher volatility (25.62%) compared to AXSM (8.92%). In terms of maximum drawdown, IOVA dropped -99.37% vs AXSM's -86.65%.
AXSM currently has the higher Sharpe Ratio (3.53 vs 1.04), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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