IOVA vs. IDYA

Last updated Jun 4, 2026

IOVA (Iovance Biotherapeutics, Inc.) and IDYA (IDEAYA Biosciences, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, IOVA returned -26.71%/yr vs 7.18%/yr for IDYA. At a 0.34 correlation, their price movements are largely independent.

Performance

IOVA vs. IDYA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Iovance Biotherapeutics, Inc. (IOVA) and IDEAYA Biosciences, Inc. (IDYA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IOVA achieves a 38.83% return, which is significantly higher than IDYA's -17.85% return.

IOVA

• 1D: -7.56%
• 1M: -1.56%
• YTD: 38.83%
• 6M: 71.49%
• 1Y: 108.24%
• 3Y*: -24.48%
• 5Y*: -26.71%
• 10Y*: -7.92%

IDYA

• 1D: 1.90%
• 1M: -1.73%
• YTD: -17.85%
• 6M: -17.30%
• 1Y: 31.24%
• 3Y*: 4.52%
• 5Y*: 7.18%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IOVA vs. IDYA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
IOVA Iovance Biotherapeutics, Inc.	38.83%	-63.11%	-8.98%	27.23%	-66.53%	-58.86%	67.63%	58.72%
IDYA IDEAYA Biosciences, Inc.	-17.85%	34.51%	-27.77%	95.82%	-23.14%	68.86%	86.67%	-32.98%

Correlation

The correlation between IOVA and IDYA is 0.40, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.40
Correlation (3Y) Calculated over the trailing 3-year period	0.44
Correlation (5Y) Calculated over the trailing 5-year period	0.44
Correlation (All Time) Calculated using the full available price history since May 24, 2019	0.34

The correlation between IOVA and IDYA shifts across timeframes, from 0.34 (all time) to 0.44 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap IOVA : $1.59B IDYA : $2.52B
EPS IOVA : -$0.93 IDYA : -$1.58
PS Ratio IOVA : 5.06 IDYA : 11.20
PB Ratio IOVA : 2.20 IDYA : 2.69
Total Revenue (TTM) IOVA : $285.61M IDYA : $225.27M
Gross Profit (TTM) IOVA : $327.04M IDYA : $215.25M
EBITDA (TTM) IOVA : -$325.45M IDYA : -$157.90M

Return for Risk

IOVA vs. IDYA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IOVA

IOVA Risk / Return Rank: 72
IOVA Sharpe Ratio Rank: 73
IOVA Sortino Ratio Rank: 77
IOVA Omega Ratio Rank: 72
IOVA Calmar Ratio Rank: 73
IOVA Martin Ratio Rank: 66

IDYA

IDYA Risk / Return Rank: 62
IDYA Sharpe Ratio Rank: 63
IDYA Sortino Ratio Rank: 60
IDYA Omega Ratio Rank: 57
IDYA Calmar Ratio Rank: 64
IDYA Martin Ratio Rank: 65

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IOVA vs. IDYA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Iovance Biotherapeutics, Inc. (IOVA) and IDEAYA Biosciences, Inc. (IDYA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IOVA	IDYA	Difference
Sharpe ratio: Return per unit of total volatility	1.07	0.69	+0.38
Sortino ratio: Return per unit of downside risk	2.16	1.26	+0.89
Omega ratio: Gain probability vs. loss probability	1.25	1.15	+0.10
Calmar ratio: Return relative to maximum drawdown	2.00	1.19	+0.81
Martin ratio: Return relative to average drawdown	3.14	2.76	+0.37
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IOVA vs. IDYA - Sharpe Ratio Comparison

The current IOVA Sharpe Ratio is 1.07, which is higher than the IDYA Sharpe Ratio of 0.69. The chart below compares the historical Sharpe Ratios of IOVA and IDYA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IOVA	IDYA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.07	0.69	+0.38
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.30	0.12	-0.42
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.10	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.13	0.19	-0.33

Drawdowns

IOVA vs. IDYA - Drawdown Comparison

The maximum IOVA drawdown since its inception was -99.37%, which is greater than IDYA's maximum drawdown of -74.64%. Use the drawdown chart below to compare losses from any high point for IOVA and IDYA.

Drawdown Indicators

	IOVA	IDYA	Difference
Max Drawdown Largest peak-to-trough decline	-99.37%	-74.64%	-24.73%
Max Drawdown (1Y) Largest decline over 1 year	-54.41%	-26.39%	-28.02%
Max Drawdown (3Y) Largest decline over 3 years	-90.50%	-69.23%	-21.27%
Max Drawdown (5Y) Largest decline over 5 years	-93.99%	-69.42%	-24.57%
Max Drawdown (10Y) Largest decline over 10 years	-96.84%	—	—
Current Drawdown Current decline from peak	-97.62%	-39.74%	-57.88%
Average Drawdown Average peak-to-trough decline	-84.16%	-30.96%	-53.20%
Ulcer Index Depth and duration of drawdowns from previous peaks	34.64%	11.34%	+23.30%

Volatility

IOVA vs. IDYA - Volatility Comparison

Iovance Biotherapeutics, Inc. (IOVA) has a higher volatility of 24.33% compared to IDEAYA Biosciences, Inc. (IDYA) at 8.05%. This indicates that IOVA's price experiences larger fluctuations and is considered to be riskier than IDYA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IOVA	IDYA	Difference
Volatility (1M) Calculated over the trailing 1-month period	24.33%	8.05%	+16.28%
Volatility (6M) Calculated over the trailing 6-month period	62.96%	30.63%	+32.33%
Volatility (1Y) Calculated over the trailing 1-year period	101.64%	45.62%	+56.02%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	89.79%	58.97%	+30.82%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	81.28%	73.84%	+7.44%

Dividends

IOVA vs. IDYA - Dividend Comparison

Neither IOVA nor IDYA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both IOVA and IDYA in my portfolio?

IOVA and IDYA have a correlation of 0.40, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IOVA or IDYA?

IOVA has higher volatility (24.33%) compared to IDYA (8.05%). In terms of maximum drawdown, IOVA dropped -99.37% vs IDYA's -74.64%.

Which has better risk-adjusted returns?

IOVA currently has the higher Sharpe Ratio (1.07 vs 0.69), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.