IMCR vs. CRSP

Last updated Jun 4, 2026

IMCR (Immunocore Holdings plc) and CRSP (CRISPR Therapeutics AG) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, IMCR returned -6.01%/yr vs -14.40%/yr for CRSP. At a 0.32 correlation, their price movements are largely independent.

Performance

IMCR vs. CRSP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Immunocore Holdings plc (IMCR) and CRISPR Therapeutics AG (CRSP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IMCR achieves a -17.46% return, which is significantly lower than CRSP's -0.69% return.

IMCR

• 1D: -3.08%
• 1M: 0.46%
• YTD: -17.46%
• 6M: -24.37%
• 1Y: -25.85%
• 3Y*: -20.19%
• 5Y*: -6.01%
• 10Y*: —

CRSP

• 1D: 0.12%
• 1M: -2.80%
• YTD: -0.69%
• 6M: -6.98%
• 1Y: 36.91%
• 3Y*: -7.12%
• 5Y*: -14.40%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IMCR vs. CRSP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
IMCR Immunocore Holdings plc	-17.46%	17.66%	-56.82%	19.71%	66.68%	-20.74%
CRSP CRISPR Therapeutics AG	-0.69%	33.23%	-37.12%	54.00%	-46.36%	-55.11%

Correlation

The correlation between IMCR and CRSP is 0.29, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.29
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.32
Correlation (All Time) Calculated using the full available price history since Feb 8, 2021	0.32

Fundamentals

Market Cap IMCR : $1.52B CRSP : $5.00B
EPS IMCR : -$0.37 CRSP : -$6.24
PS Ratio IMCR : 3.79 CRSP : 1.16K
PB Ratio IMCR : 3.85 CRSP : 2.76
Total Revenue (TTM) IMCR : $385.76M CRSP : $4.10M
Gross Profit (TTM) IMCR : $381.15M CRSP : -$171.17M
EBITDA (TTM) IMCR : -$3.01M CRSP : -$509.21M

Return for Risk

IMCR vs. CRSP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IMCR

IMCR Risk / Return Rank: 11
IMCR Sharpe Ratio Rank: 12
IMCR Sortino Ratio Rank: 13
IMCR Omega Ratio Rank: 15
IMCR Calmar Ratio Rank: 8
IMCR Martin Ratio Rank: 5

CRSP

CRSP Risk / Return Rank: 58
CRSP Sharpe Ratio Rank: 60
CRSP Sortino Ratio Rank: 60
CRSP Omega Ratio Rank: 56
CRSP Calmar Ratio Rank: 59
CRSP Martin Ratio Rank: 55

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IMCR vs. CRSP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Immunocore Holdings plc (IMCR) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IMCR	CRSP	Difference
Sharpe ratio: Return per unit of total volatility	-0.69	0.60	-1.29
Sortino ratio: Return per unit of downside risk	-0.90	1.28	-2.18
Omega ratio: Gain probability vs. loss probability	0.90	1.15	-0.25
Calmar ratio: Return relative to maximum drawdown	-0.85	0.88	-1.73
Martin ratio: Return relative to average drawdown	-1.52	1.49	-3.01
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IMCR vs. CRSP - Sharpe Ratio Comparison

The current IMCR Sharpe Ratio is -0.69, which is lower than the CRSP Sharpe Ratio of 0.60. The chart below compares the historical Sharpe Ratios of IMCR and CRSP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IMCR	CRSP	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.69	0.60	-1.29
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.12	-0.24	+0.12
Sharpe Ratio (All Time) Calculated using the full available price history	-0.14	0.23	-0.36

Drawdowns

IMCR vs. CRSP - Drawdown Comparison

The maximum IMCR drawdown since its inception was -67.45%, smaller than the maximum CRSP drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for IMCR and CRSP.

Drawdown Indicators

	IMCR	CRSP	Difference
Max Drawdown Largest peak-to-trough decline	-67.45%	-85.11%	+17.66%
Max Drawdown (1Y) Largest decline over 1 year	-30.60%	-42.25%	+11.65%
Max Drawdown (3Y) Largest decline over 3 years	-67.45%	-64.91%	-2.54%
Max Drawdown (5Y) Largest decline over 5 years	-67.45%	-80.68%	+13.23%
Current Drawdown Current decline from peak	-61.98%	-75.20%	+13.22%
Average Drawdown Average peak-to-trough decline	-36.56%	-49.17%	+12.61%
Ulcer Index Depth and duration of drawdowns from previous peaks	17.42%	24.92%	-7.50%

Volatility

IMCR vs. CRSP - Volatility Comparison

The current volatility for Immunocore Holdings plc (IMCR) is 11.53%, while CRISPR Therapeutics AG (CRSP) has a volatility of 14.90%. This indicates that IMCR experiences smaller price fluctuations and is considered to be less risky than CRSP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IMCR	CRSP	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.53%	14.90%	-3.37%
Volatility (6M) Calculated over the trailing 6-month period	26.30%	42.49%	-16.19%
Volatility (1Y) Calculated over the trailing 1-year period	37.66%	61.68%	-24.02%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	50.37%	60.46%	-10.09%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	54.40%	64.27%	-9.87%

Dividends

IMCR vs. CRSP - Dividend Comparison

Neither IMCR nor CRSP has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both IMCR and CRSP in my portfolio?

IMCR and CRSP have a correlation of 0.29, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IMCR or CRSP?

CRSP has higher volatility (14.90%) compared to IMCR (11.53%). In terms of maximum drawdown, IMCR dropped -67.45% vs CRSP's -85.11%.

Which has better risk-adjusted returns?

CRSP currently has the higher Sharpe Ratio (0.60 vs -0.69), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.