IBRN vs. WDNA

Last updated Jun 4, 2026

IBRN (iShares Neuroscience and Healthcare ETF) and WDNA (WisdomTree BioRevolution Fund) are both Health & Biotech Equities funds - IBRN tracks the NYSE FactSet Global Neuro Biopharma and MedTech Index while WDNA tracks the WisdomTree BioRevolution Index. Both are passively managed. Over the past 3 years, IBRN returned 11.68%/yr vs 2.45%/yr for WDNA. Their correlation of 0.81 suggests significant overlap in exposure. IBRN charges 0.47%/yr vs 0.45%/yr for WDNA.

Performance

IBRN vs. WDNA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Neuroscience and Healthcare ETF (IBRN) and WisdomTree BioRevolution Fund (WDNA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IBRN achieves a 6.25% return, which is significantly higher than WDNA's 5.85% return.

IBRN

• 1D: 1.56%
• 1M: -1.78%
• YTD: 6.25%
• 6M: 10.50%
• 1Y: 52.08%
• 3Y*: 11.68%
• 5Y*: —
• 10Y*: —

WDNA

• 1D: 1.24%
• 1M: -0.73%
• YTD: 5.85%
• 6M: 8.14%
• 1Y: 45.86%
• 3Y*: 2.45%
• 5Y*: -5.33%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IBRN vs. WDNA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
IBRN iShares Neuroscience and Healthcare ETF	6.25%	28.49%	-2.78%	0.92%	5.85%
WDNA WisdomTree BioRevolution Fund	5.85%	22.68%	-14.18%	-2.07%	-6.85%

Correlation

The correlation between IBRN and WDNA is 0.78, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.78
Correlation (3Y) Calculated over the trailing 3-year period	0.80
Correlation (All Time) Calculated using the full available price history since Aug 29, 2022	0.81

The correlation between IBRN and WDNA has been stable across timeframes, ranging from 0.78 to 0.81 - a consistent structural relationship.

IBRN vs. WDNA - Sectors Allocation Comparison

Sectors	IBRN	WDNA
Healthcare	100.0%	85.0%
Basic Materials	-	6.5%
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	3.0%
Energy	-	1.1%
Financial Services	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

IBRN vs. WDNA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IBRN

IBRN Risk / Return Rank: 69
IBRN Sharpe Ratio Rank: 61
IBRN Sortino Ratio Rank: 63
IBRN Omega Ratio Rank: 54
IBRN Calmar Ratio Rank: 91
IBRN Martin Ratio Rank: 76

WDNA

WDNA Risk / Return Rank: 57
WDNA Sharpe Ratio Rank: 53
WDNA Sortino Ratio Rank: 55
WDNA Omega Ratio Rank: 48
WDNA Calmar Ratio Rank: 78
WDNA Martin Ratio Rank: 53

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IBRN vs. WDNA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Neuroscience and Healthcare ETF (IBRN) and WisdomTree BioRevolution Fund (WDNA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IBRN	WDNA	Difference
Sharpe ratio Return per unit of total volatility	2.07	1.81	+0.26
Sortino ratio Return per unit of downside risk	2.92	2.64	+0.27
Omega ratio Gain probability vs. loss probability	1.33	1.30	+0.04
Calmar ratio Return relative to maximum drawdown	5.95	3.94	+2.01
Martin ratio Return relative to average drawdown	14.63	8.95	+5.69
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IBRN vs. WDNA - Sharpe Ratio Comparison

The current IBRN Sharpe Ratio is 2.07, which is comparable to the WDNA Sharpe Ratio of 1.81. The chart below compares the historical Sharpe Ratios of IBRN and WDNA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IBRN	WDNA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.07	1.81	+0.26
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.21	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.39	-0.21	+0.60

Drawdowns

IBRN vs. WDNA - Drawdown Comparison

The maximum IBRN drawdown since its inception was -35.38%, smaller than the maximum WDNA drawdown of -58.87%. Use the drawdown chart below to compare losses from any high point for IBRN and WDNA.

Drawdown Indicators

	IBRN	WDNA	Difference
Max Drawdown Largest peak-to-trough decline	-35.38%	-58.87%	+23.49%
Max Drawdown (1Y) Largest decline over 1 year	-8.80%	-11.70%	+2.90%
Max Drawdown (3Y) Largest decline over 3 years	-35.38%	-38.25%	+2.87%
Max Drawdown (5Y) Largest decline over 5 years	—	-58.87%	—
Current Drawdown Current decline from peak	-4.82%	-31.86%	+27.04%
Average Drawdown Average peak-to-trough decline	-9.83%	-35.65%	+25.82%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.57%	5.14%	-1.57%

Volatility

IBRN vs. WDNA - Volatility Comparison

iShares Neuroscience and Healthcare ETF (IBRN) has a higher volatility of 7.69% compared to WisdomTree BioRevolution Fund (WDNA) at 6.75%. This indicates that IBRN's price experiences larger fluctuations and is considered to be riskier than WDNA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IBRN	WDNA	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.69%	6.75%	+0.94%
Volatility (6M) Calculated over the trailing 6-month period	19.08%	16.39%	+2.69%
Volatility (1Y) Calculated over the trailing 1-year period	25.36%	25.53%	-0.17%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.32%	25.04%	+0.28%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.32%	25.04%	+0.28%

IBRN vs. WDNA - Expense Ratio Comparison

IBRN has a 0.47% expense ratio, which is higher than WDNA's 0.45% expense ratio.

Dividends

IBRN vs. WDNA - Dividend Comparison

IBRN's dividend yield for the trailing twelve months is around 0.93%, less than WDNA's 4.31% yield.

Position	TTM	2025	2024	2023	2022	2021
IBRN iShares Neuroscience and Healthcare ETF	0.93%	0.99%	0.40%	0.06%	0.00%	0.00%
WDNA WisdomTree BioRevolution Fund	4.31%	4.57%	0.75%	0.80%	0.38%	0.10%

Frequently Asked Questions

Can I hold both IBRN and WDNA in my portfolio?

IBRN and WDNA have a correlation of 0.78, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IBRN or WDNA?

IBRN has higher volatility (7.69%) compared to WDNA (6.75%). In terms of maximum drawdown, IBRN dropped -35.38% vs WDNA's -58.87%.

Which ETF is better, IBRN or WDNA?

On 3-year performance, IBRN leads with 11.68% vs 2.45% for WDNA. On fees, WDNA is cheaper at 0.45% per year. On volatility, WDNA has been the lower-risk option at 6.75%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IBRN or WDNA?

Over the 3-year period, IBRN has performed better with a 11.68% return vs 2.45%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IBRN or WDNA?

WDNA is cheaper with a 0.45% expense ratio, compared with 0.47% for IBRN.

Which ETF pays a higher dividend yield, IBRN or WDNA?

WDNA has the higher dividend yield at 4.31%, compared with 0.93% for IBRN.

What is the main difference between IBRN and WDNA?

IBRN tracks NYSE FactSet Global Neuro Biopharma and MedTech Index, while WDNA tracks WisdomTree BioRevolution Index. They also come from different issuers: iShares and WisdomTree. Their fees differ too: 0.47% for IBRN and 0.45% for WDNA.

Which has better risk-adjusted returns?

IBRN currently has the higher Sharpe Ratio (2.07 vs 1.81), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.