IBRN vs. SMST

Last updated Jul 14, 2026

IBRN (iShares Neuroscience and Healthcare ETF) and SMST (Defiance Daily Target 2X Short MSTR ETF) are both exchange-traded funds - IBRN is a Health & Biotech Equities fund tracking the NYSE FactSet Global Neuro Biopharma and MedTech Index, while SMST is a Inverse Equities fund actively managed by Defiance. IBRN is passively managed, while SMST is actively managed. Over the past year, IBRN returned 69.86% vs 240.03% for SMST. At a correlation of -0.33, they often move in opposite directions. IBRN charges 0.47%/yr vs 1.29%/yr for SMST.

Performance

IBRN vs. SMST - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Neuroscience and Healthcare ETF (IBRN) and Defiance Daily Target 2X Short MSTR ETF (SMST). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IBRN achieves a 18.23% return, which is significantly higher than SMST's -27.96% return.

IBRN

• 1D: -2.16%
• 1M: 9.69%
• 6M: 19.74%
• YTD: 18.23%
• 1Y: 69.86%
• 3Y*: 16.48%
• 5Y*: —
• 10Y*: —

SMST

• 1D: 5.26%
• 1M: 44.38%
• 6M: -15.07%
• YTD: -27.96%
• 1Y: 240.03%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IBRN vs. SMST - Yearly Performance Comparison

	2026 (YTD)	2025	2024
IBRN iShares Neuroscience and Healthcare ETF	18.23%	28.49%	-1.48%
SMST Defiance Daily Target 2X Short MSTR ETF	-27.96%	-44.36%	-91.71%

Correlation

The correlation between IBRN and SMST is -0.29, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.29
Correlation (All Time) Calculated using the full available price history since Aug 21, 2024	-0.33

Return for Risk

IBRN vs. SMST — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IBRN

IBRN Risk / Return Rank: 93
IBRN Sharpe Ratio Rank: 94
IBRN Sortino Ratio Rank: 92
IBRN Omega Ratio Rank: 88
IBRN Calmar Ratio Rank: 97
IBRN Martin Ratio Rank: 95

SMST

SMST Risk / Return Rank: 60
SMST Sharpe Ratio Rank: 62
SMST Sortino Ratio Rank: 63
SMST Omega Ratio Rank: 63
SMST Calmar Ratio Rank: 71
SMST Martin Ratio Rank: 43

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IBRN vs. SMST - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Neuroscience and Healthcare ETF (IBRN) and Defiance Daily Target 2X Short MSTR ETF (SMST). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	IBRN	SMST	Difference
Sharpe ratio: Return per unit of total volatility	2.76	1.62	+1.14
Sortino ratio: Return per unit of downside risk	3.61	2.33	+1.27
Omega ratio: Gain probability vs. loss probability	1.43	1.30	+0.12
Calmar ratio: Return relative to maximum drawdown	7.98	2.83	+5.15
Martin ratio: Return relative to average drawdown	22.47	5.47	+17.00

IBRN vs. SMST - Sharpe Ratio Comparison

The current IBRN Sharpe Ratio is 2.76, which is higher than the SMST Sharpe Ratio of 1.62. The chart below compares the historical Sharpe Ratios of IBRN and SMST, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

IBRN vs. SMST - Drawdown Comparison

The maximum IBRN drawdown since its inception was -35.38%, smaller than the maximum SMST drawdown of -99.25%. Use the drawdown chart below to compare losses from any high point for IBRN and SMST.

Drawdown Indicators

	IBRN	SMST	Difference
Max Drawdown Largest peak-to-trough decline	-35.38%	-99.25%	+63.87%
Max Drawdown (1Y) Largest decline over 1 year	-8.80%	-85.39%	+76.59%
Max Drawdown (3Y) Largest decline over 3 years	-35.38%	—	—
Current Drawdown Current decline from peak	-5.16%	-97.17%	+92.01%
Average Drawdown Average peak-to-trough decline	-9.63%	-90.89%	+81.26%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.12%	44.09%	-40.97%

Volatility

IBRN vs. SMST - Volatility Comparison

The current volatility for iShares Neuroscience and Healthcare ETF (IBRN) is 6.66%, while Defiance Daily Target 2X Short MSTR ETF (SMST) has a volatility of 56.59%. This indicates that IBRN experiences smaller price fluctuations and is considered to be less risky than SMST based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IBRN	SMST	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.66%	56.59%	-49.93%
Volatility (6M) Calculated over the trailing 6-month period	19.29%	135.88%	-116.59%
Volatility (1Y) Calculated over the trailing 1-year period	25.51%	149.23%	-123.72%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.34%	167.74%	-142.40%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.34%	167.74%	-142.40%

IBRN vs. SMST - Expense Ratio Comparison

IBRN has a 0.47% expense ratio, which is lower than SMST's 1.29% expense ratio.

Dividends

IBRN vs. SMST - Dividend Comparison

IBRN's dividend yield for the trailing twelve months is around 0.84%, while SMST has not paid dividends to shareholders.

Position	TTM	2025	2024	2023
IBRN iShares Neuroscience and Healthcare ETF	0.84%	0.99%	0.40%	0.06%
SMST Defiance Daily Target 2X Short MSTR ETF	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both IBRN and SMST in my portfolio?

IBRN and SMST have a correlation of -0.29, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IBRN or SMST?

SMST has higher volatility (56.59%) compared to IBRN (6.66%). In terms of maximum drawdown, IBRN dropped -35.38% vs SMST's -99.25%.

Which ETF is better, IBRN or SMST?

On 1-year performance, SMST leads with 240.03% vs 69.86% for IBRN. On fees, IBRN is cheaper at 0.47% per year. On volatility, IBRN has been the lower-risk option at 6.66%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IBRN or SMST?

Over the 1-year period, SMST has performed better with a 240.03% return vs 69.86%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IBRN or SMST?

IBRN is cheaper with a 0.47% expense ratio, compared with 1.29% for SMST.

Which ETF pays a higher dividend yield, IBRN or SMST?

IBRN has the higher dividend yield at 0.84%, compared with 0.00% for SMST.

What is the main difference between IBRN and SMST?

IBRN is categorized as Health & Biotech Equities, while SMST is Inverse Equities. They also come from different issuers: iShares and Defiance. Their fees differ too: 0.47% for IBRN and 1.29% for SMST.

Which has better risk-adjusted returns?

IBRN currently has the higher Sharpe Ratio (2.76 vs 1.62), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.