GNOM vs. SMST

Last updated Jun 28, 2026

GNOM (Global X Genomics & Biotechnology ETF) and SMST (Defiance Daily Target 2X Short MSTR ETF) are both exchange-traded funds - GNOM is a Health & Biotech Equities fund tracking the Solactive Genomics Index, while SMST is a Inverse Equities fund actively managed by Defiance. GNOM is passively managed, while SMST is actively managed. Over the past year, GNOM returned 69.62% vs 254.29% for SMST. At a correlation of -0.33, they often move in opposite directions. GNOM charges 0.50%/yr vs 1.29%/yr for SMST.

Performance

GNOM vs. SMST - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Global X Genomics & Biotechnology ETF (GNOM) and Defiance Daily Target 2X Short MSTR ETF (SMST). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, GNOM achieves a 23.79% return, which is significantly higher than SMST's 2.24% return.

GNOM

• 1D: 2.39%
• 1M: 13.26%
• YTD: 23.79%
• 6M: 20.74%
• 1Y: 69.62%
• 3Y*: 5.90%
• 5Y*: -9.86%
• 10Y*: —

SMST

• 1D: 7.78%
• 1M: 205.67%
• YTD: 2.24%
• 6M: 11.23%
• 1Y: 254.29%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

GNOM vs. SMST - Yearly Performance Comparison

	2026 (YTD)	2025	2024
GNOM Global X Genomics & Biotechnology ETF	23.79%	18.65%	-15.49%
SMST Defiance Daily Target 2X Short MSTR ETF	2.24%	-44.36%	-91.71%

Correlation

The correlation between GNOM and SMST is -0.33, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.33
Correlation (All Time) Calculated using the full available price history since Aug 21, 2024	-0.33

Return for Risk

GNOM vs. SMST — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GNOM

GNOM Risk / Return Rank: 81
GNOM Sharpe Ratio Rank: 89
GNOM Sortino Ratio Rank: 86
GNOM Omega Ratio Rank: 76
GNOM Calmar Ratio Rank: 82
GNOM Martin Ratio Rank: 69

SMST

SMST Risk / Return Rank: 59
SMST Sharpe Ratio Rank: 63
SMST Sortino Ratio Rank: 59
SMST Omega Ratio Rank: 58
SMST Calmar Ratio Rank: 71
SMST Martin Ratio Rank: 42

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GNOM vs. SMST - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Global X Genomics & Biotechnology ETF (GNOM) and Defiance Daily Target 2X Short MSTR ETF (SMST). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	GNOM	SMST	Difference
Sharpe ratio: Return per unit of total volatility	2.55	1.78	+0.77
Sortino ratio: Return per unit of downside risk	3.39	2.42	+0.97
Omega ratio: Gain probability vs. loss probability	1.39	1.31	+0.08
Calmar ratio: Return relative to maximum drawdown	3.85	3.06	+0.80
Martin ratio: Return relative to average drawdown	11.06	6.03	+5.04

GNOM vs. SMST - Sharpe Ratio Comparison

The current GNOM Sharpe Ratio is 2.55, which is higher than the SMST Sharpe Ratio of 1.78. The chart below compares the historical Sharpe Ratios of GNOM and SMST, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

GNOM vs. SMST - Drawdown Comparison

The maximum GNOM drawdown since its inception was -75.00%, smaller than the maximum SMST drawdown of -99.25%. Use the drawdown chart below to compare losses from any high point for GNOM and SMST.

Drawdown Indicators

	GNOM	SMST	Difference
Max Drawdown Largest peak-to-trough decline	-75.00%	-99.25%	+24.25%
Max Drawdown (1Y) Largest decline over 1 year	-18.17%	-85.39%	+67.22%
Max Drawdown (3Y) Largest decline over 3 years	-44.24%	—	—
Max Drawdown (5Y) Largest decline over 5 years	-72.29%	—	—
Current Drawdown Current decline from peak	-48.85%	-95.98%	+47.13%
Average Drawdown Average peak-to-trough decline	-40.65%	-90.75%	+50.10%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.32%	43.22%	-36.90%

Volatility

GNOM vs. SMST - Volatility Comparison

The current volatility for Global X Genomics & Biotechnology ETF (GNOM) is 9.80%, while Defiance Daily Target 2X Short MSTR ETF (SMST) has a volatility of 46.17%. This indicates that GNOM experiences smaller price fluctuations and is considered to be less risky than SMST based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GNOM	SMST	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.80%	46.17%	-36.37%
Volatility (6M) Calculated over the trailing 6-month period	20.69%	130.39%	-109.70%
Volatility (1Y) Calculated over the trailing 1-year period	27.48%	146.31%	-118.83%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	33.71%	167.17%	-133.46%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	34.18%	167.17%	-132.99%

GNOM vs. SMST - Expense Ratio Comparison

GNOM has a 0.50% expense ratio, which is lower than SMST's 1.29% expense ratio.

Dividends

GNOM vs. SMST - Dividend Comparison

GNOM's dividend yield for the trailing twelve months is around 1.11%, while SMST has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020
GNOM Global X Genomics & Biotechnology ETF	1.05%	1.37%	0.00%	0.00%	0.00%	0.03%	0.14%
SMST Defiance Daily Target 2X Short MSTR ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both GNOM and SMST in my portfolio?

GNOM and SMST have a correlation of -0.33, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, GNOM or SMST?

SMST has higher volatility (46.17%) compared to GNOM (9.80%). In terms of maximum drawdown, GNOM dropped -75.00% vs SMST's -99.25%.

Which ETF is better, GNOM or SMST?

On 1-year performance, SMST leads with 254.29% vs 69.62% for GNOM. On fees, GNOM is cheaper at 0.50% per year. On volatility, GNOM has been the lower-risk option at 9.80%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, GNOM or SMST?

Over the 1-year period, SMST has performed better with a 254.29% return vs 69.62%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, GNOM or SMST?

GNOM is cheaper with a 0.50% expense ratio, compared with 1.29% for SMST.

Which ETF pays a higher dividend yield, GNOM or SMST?

GNOM has the higher dividend yield at 1.05%, compared with 0.00% for SMST.

What is the main difference between GNOM and SMST?

GNOM is categorized as Health & Biotech Equities, while SMST is Inverse Equities. They also come from different issuers: Global X and Defiance. Their fees differ too: 0.50% for GNOM and 1.29% for SMST.

Which has better risk-adjusted returns?

GNOM currently has the higher Sharpe Ratio (2.55 vs 1.78), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.