GNOG.L vs. ESIH.L

Last updated Jun 5, 2026

GNOG.L (Global X Genomics & Biotechnology UCITS ETF) and ESIH.L (iShares MSCI Europe Health Care Sector UCITS ETF) are both Health & Biotech Equities funds tracking the MSCI World/Health Care NR USD, from Global X and iShares respectively. Both are passively managed. Over the past 3 years, GNOG.L returned -1.86%/yr vs 2.83%/yr for ESIH.L. At a 0.40 correlation, their price movements are largely independent. GNOG.L charges 0.50%/yr vs 0.18%/yr for ESIH.L.

Performance

GNOG.L vs. ESIH.L - Performance Comparison

The chart below illustrates the hypothetical performance of a £10,000 investment in Global X Genomics & Biotechnology UCITS ETF (GNOG.L) and iShares MSCI Europe Health Care Sector UCITS ETF (ESIH.L). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, GNOG.L achieves a 12.27% return, which is significantly higher than ESIH.L's -2.72% return.

GNOG.L

• 1D: 5.70%
• 1M: 13.66%
• YTD: 12.27%
• 6M: 9.47%
• 1Y: 59.40%
• 3Y*: -1.86%
• 5Y*: —
• 10Y*: —

ESIH.L

• 1D: 3.06%
• 1M: 1.79%
• YTD: -2.72%
• 6M: -1.50%
• 1Y: 8.89%
• 3Y*: 2.83%
• 5Y*: 5.89%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

GNOG.L vs. ESIH.L - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
GNOG.L Global X Genomics & Biotechnology UCITS ETF	12.27%	12.03%	-16.98%	-11.35%	-29.74%	-10.30%
ESIH.L iShares MSCI Europe Health Care Sector UCITS ETF	-2.72%	12.76%	-0.46%	5.44%	1.56%	-1.76%

Correlation

The correlation between GNOG.L and ESIH.L is 0.51, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.51
Correlation (3Y) Calculated over the trailing 3-year period	0.41
Correlation (All Time) Calculated using the full available price history since Nov 5, 2021	0.40

The correlation between GNOG.L and ESIH.L shifts across timeframes, from 0.40 (all time) to 0.51 (1 year), reflecting how their relationship changes across market environments.

GNOG.L vs. ESIH.L - Sectors Allocation Comparison

Sectors	GNOG.L	ESIH.L
Healthcare	99.7%	100.0%
Technology	0.3%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-
Industrials	-	-
Real Estate	-	-
Utilities	-	-

Return for Risk

GNOG.L vs. ESIH.L — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GNOG.L

GNOG.L Risk / Return Rank: 62
GNOG.L Sharpe Ratio Rank: 66
GNOG.L Sortino Ratio Rank: 65
GNOG.L Omega Ratio Rank: 58
GNOG.L Calmar Ratio Rank: 70
GNOG.L Martin Ratio Rank: 52

ESIH.L

ESIH.L Risk / Return Rank: 17
ESIH.L Sharpe Ratio Rank: 18
ESIH.L Sortino Ratio Rank: 18
ESIH.L Omega Ratio Rank: 17
ESIH.L Calmar Ratio Rank: 17
ESIH.L Martin Ratio Rank: 17

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GNOG.L vs. ESIH.L - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Global X Genomics & Biotechnology UCITS ETF (GNOG.L) and iShares MSCI Europe Health Care Sector UCITS ETF (ESIH.L). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	GNOG.L	ESIH.L	Difference
Sharpe ratio: Return per unit of total volatility	2.16	0.53	+1.63
Sortino ratio: Return per unit of downside risk	2.95	0.88	+2.07
Omega ratio: Gain probability vs. loss probability	1.35	1.10	+0.24
Calmar ratio: Return relative to maximum drawdown	3.44	0.64	+2.80
Martin ratio: Return relative to average drawdown	8.72	1.54	+7.18
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

GNOG.L vs. ESIH.L - Sharpe Ratio Comparison

The current GNOG.L Sharpe Ratio is 2.16, which is higher than the ESIH.L Sharpe Ratio of 0.53. The chart below compares the historical Sharpe Ratios of GNOG.L and ESIH.L, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	GNOG.L	ESIH.L	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.16	0.53	+1.63
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.38	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.36	0.39	-0.75

Drawdowns

GNOG.L vs. ESIH.L - Drawdown Comparison

The maximum GNOG.L drawdown since its inception was -67.50%, which is greater than ESIH.L's maximum drawdown of -24.44%. Use the drawdown chart below to compare losses from any high point for GNOG.L and ESIH.L.

Drawdown Indicators

	GNOG.L	ESIH.L	Difference
Max Drawdown Largest peak-to-trough decline	-67.50%	-24.44%	-43.06%
Max Drawdown (1Y) Largest decline over 1 year	-17.16%	-13.81%	-3.35%
Max Drawdown (3Y) Largest decline over 3 years	-47.97%	-24.44%	-23.53%
Max Drawdown (5Y) Largest decline over 5 years	—	-24.44%	—
Current Drawdown Current decline from peak	-41.78%	-10.94%	-30.84%
Average Drawdown Average peak-to-trough decline	-44.20%	-6.76%	-37.44%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.79%	5.77%	+1.02%

Volatility

GNOG.L vs. ESIH.L - Volatility Comparison

Global X Genomics & Biotechnology UCITS ETF (GNOG.L) has a higher volatility of 7.97% compared to iShares MSCI Europe Health Care Sector UCITS ETF (ESIH.L) at 5.50%. This indicates that GNOG.L's price experiences larger fluctuations and is considered to be riskier than ESIH.L based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GNOG.L	ESIH.L	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.97%	5.50%	+2.47%
Volatility (6M) Calculated over the trailing 6-month period	19.73%	12.21%	+7.52%
Volatility (1Y) Calculated over the trailing 1-year period	27.38%	16.83%	+10.55%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	31.21%	15.50%	+15.71%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	31.21%	15.36%	+15.85%

GNOG.L vs. ESIH.L - Expense Ratio Comparison

GNOG.L has a 0.50% expense ratio, which is higher than ESIH.L's 0.18% expense ratio.

Dividends

GNOG.L vs. ESIH.L - Dividend Comparison

Neither GNOG.L nor ESIH.L has paid dividends to shareholders.

Tickers have no history of dividend payments

Frequently Asked Questions

Can I hold both GNOG.L and ESIH.L in my portfolio?

GNOG.L and ESIH.L have a correlation of 0.51, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, GNOG.L or ESIH.L?

On fees, ESIH.L is cheaper at 0.18% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, GNOG.L or ESIH.L?

ESIH.L is cheaper with a 0.18% expense ratio, compared with 0.50% for GNOG.L.

What is the main difference between GNOG.L and ESIH.L?

Both ETFs track MSCI World/Health Care NR USD. They also come from different issuers: Global X and iShares. Their fees differ too: 0.50% for GNOG.L and 0.18% for ESIH.L.