GLUE vs. SPY

Last updated Jun 3, 2026

GLUE (Monte Rosa Therapeutics, Inc.) is a stock, while SPY (State Street SPDR S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 3 years, GLUE returned 32.89%/yr vs 22.64%/yr for SPY. At a 0.33 correlation, their price movements are largely independent.

Performance

GLUE vs. SPY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Monte Rosa Therapeutics, Inc. (GLUE) and State Street SPDR S&P 500 ETF (SPY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, GLUE achieves a 13.14% return, which is significantly higher than SPY's 11.69% return.

GLUE

• 1D: -9.81%
• 1M: -5.64%
• YTD: 13.14%
• 6M: 15.12%
• 1Y: 294.22%
• 3Y*: 32.89%
• 5Y*: —
• 10Y*: —

SPY

• 1D: 0.14%
• 1M: 5.40%
• YTD: 11.69%
• 6M: 12.09%
• 1Y: 29.62%
• 3Y*: 22.64%
• 5Y*: 14.20%
• 10Y*: 15.57%

*Multi-year figures are annualized to reflect compound growth (CAGR)

GLUE vs. SPY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
GLUE Monte Rosa Therapeutics, Inc.	13.14%	125.94%	22.83%	-25.76%	-62.73%	-3.59%
SPY State Street SPDR S&P 500 ETF	11.69%	17.72%	24.89%	26.18%	-18.18%	12.48%

Correlation

The correlation between GLUE and SPY is 0.31, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.31
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (All Time) Calculated using the full available price history since Jun 25, 2021	0.33

Return for Risk

GLUE vs. SPY — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GLUE

GLUE Risk / Return Rank: 94
GLUE Sharpe Ratio Rank: 95
GLUE Sortino Ratio Rank: 96
GLUE Omega Ratio Rank: 92
GLUE Calmar Ratio Rank: 95
GLUE Martin Ratio Rank: 94

SPY

SPY Risk / Return Rank: 75
SPY Sharpe Ratio Rank: 77
SPY Sortino Ratio Rank: 75
SPY Omega Ratio Rank: 76
SPY Calmar Ratio Rank: 68
SPY Martin Ratio Rank: 80

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GLUE vs. SPY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Monte Rosa Therapeutics, Inc. (GLUE) and State Street SPDR S&P 500 ETF (SPY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	GLUE	SPY	Difference
Sharpe ratio Return per unit of total volatility	3.20	2.52	+0.68
Sortino ratio Return per unit of downside risk	4.33	3.42	+0.92
Omega ratio Gain probability vs. loss probability	1.50	1.46	+0.04
Calmar ratio Return relative to maximum drawdown	7.75	3.42	+4.34
Martin ratio Return relative to average drawdown	17.17	15.93	+1.25
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

GLUE vs. SPY - Sharpe Ratio Comparison

The current GLUE Sharpe Ratio is 3.20, which is comparable to the SPY Sharpe Ratio of 2.52. The chart below compares the historical Sharpe Ratios of GLUE and SPY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	GLUE	SPY	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	3.20	2.52	+0.68
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.84	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.87	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.03	0.59	-0.62

Drawdowns

GLUE vs. SPY - Drawdown Comparison

The maximum GLUE drawdown since its inception was -94.08%, which is greater than SPY's maximum drawdown of -55.19%. Use the drawdown chart below to compare losses from any high point for GLUE and SPY.

Drawdown Indicators

	GLUE	SPY	Difference
Max Drawdown Largest peak-to-trough decline	-94.08%	-55.19%	-38.89%
Max Drawdown (1Y) Largest decline over 1 year	-41.84%	-8.88%	-32.96%
Max Drawdown (3Y) Largest decline over 3 years	-67.19%	-18.76%	-48.43%
Max Drawdown (5Y) Largest decline over 5 years	—	-24.50%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-33.72%	—
Current Drawdown Current decline from peak	-57.97%	0.00%	-57.97%
Average Drawdown Average peak-to-trough decline	-74.62%	-9.05%	-65.57%
Ulcer Index Depth and duration of drawdowns from previous peaks	18.89%	1.91%	+16.98%

Volatility

GLUE vs. SPY - Volatility Comparison

Monte Rosa Therapeutics, Inc. (GLUE) has a higher volatility of 17.10% compared to State Street SPDR S&P 500 ETF (SPY) at 2.75%. This indicates that GLUE's price experiences larger fluctuations and is considered to be riskier than SPY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GLUE	SPY	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.10%	2.75%	+14.35%
Volatility (6M) Calculated over the trailing 6-month period	57.34%	8.89%	+48.45%
Volatility (1Y) Calculated over the trailing 1-year period	92.88%	11.81%	+81.07%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	101.35%	17.05%	+84.30%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	101.35%	17.94%	+83.41%

Dividends

GLUE vs. SPY - Dividend Comparison

GLUE has not paid dividends to shareholders, while SPY's dividend yield for the trailing twelve months is around 0.97%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
GLUE Monte Rosa Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SPY State Street SPDR S&P 500 ETF	0.97%	1.07%	1.21%	1.40%	1.65%	1.20%	1.52%	1.75%	2.04%	1.80%	2.03%	2.06%

Frequently Asked Questions

Can I hold both GLUE and SPY in my portfolio?

GLUE and SPY have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, GLUE or SPY?

GLUE has higher volatility (17.10%) compared to SPY (2.75%). In terms of maximum drawdown, GLUE dropped -94.08% vs SPY's -55.19%.

Which has better risk-adjusted returns?

GLUE currently has the higher Sharpe Ratio (3.20 vs 2.52), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.