GHRS vs. PFE

Last updated Jun 23, 2026

GHRS (GH Research PLC) and PFE (Pfizer Inc.) are both stocks. Both are in the Healthcare sector — GHRS in Biotechnology, PFE in Drug Manufacturers - General. Over the past 3 years, GHRS returned 22.59%/yr vs -7.59%/yr for PFE. At a 0.08 correlation, their price movements are largely independent.

Performance

GHRS vs. PFE - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in GH Research PLC (GHRS) and Pfizer Inc. (PFE). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, GHRS achieves a 73.94% return, which is significantly higher than PFE's 4.10% return.

GHRS

• 1D: -0.67%
• 1M: -0.14%
• YTD: 73.94%
• 6M: 69.66%
• 1Y: 79.45%
• 3Y*: 22.59%
• 5Y*: —
• 10Y*: —

PFE

• 1D: -0.52%
• 1M: -3.17%
• YTD: 4.10%
• 6M: 2.82%
• 1Y: 11.94%
• 3Y*: -7.59%
• 5Y*: -3.66%
• 10Y*: 1.96%

*Multi-year figures are annualized to reflect compound growth (CAGR)

GHRS vs. PFE - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
GHRS GH Research PLC	73.94%	81.43%	20.69%	-40.33%	-58.34%	6.05%
PFE Pfizer Inc.	4.10%	0.65%	-2.22%	-41.26%	-10.41%	53.38%

Correlation

The correlation between GHRS and PFE is 0.13, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.13
Correlation (3Y) Calculated over the trailing 3-year period	0.09
Correlation (All Time) Calculated using the full available price history since Jun 25, 2021	0.08

Fundamentals

Market Cap GHRS : $1.37B PFE : $143.73B
EPS GHRS : -$0.91 PFE : $1.31
PB Ratio GHRS : 5.20 PFE : 1.60
Total Revenue (TTM) GHRS : $0.00 PFE : $63.32B
Gross Profit (TTM) GHRS : -$268.00K PFE : $43.91B
EBITDA (TTM) GHRS : -$58.38M PFE : $16.94B

Return for Risk

GHRS vs. PFE — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GHRS

GHRS Risk / Return Rank: 73
GHRS Sharpe Ratio Rank: 73
GHRS Sortino Ratio Rank: 73
GHRS Omega Ratio Rank: 71
GHRS Calmar Ratio Rank: 76
GHRS Martin Ratio Rank: 69

PFE

PFE Risk / Return Rank: 58
PFE Sharpe Ratio Rank: 60
PFE Sortino Ratio Rank: 54
PFE Omega Ratio Rank: 52
PFE Calmar Ratio Rank: 64
PFE Martin Ratio Rank: 62

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GHRS vs. PFE - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for GH Research PLC (GHRS) and Pfizer Inc. (PFE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	GHRS	PFE	Difference
Sharpe ratio: Return per unit of total volatility	1.02	0.50	+0.52
Sortino ratio: Return per unit of downside risk	1.84	0.92	+0.92
Omega ratio: Gain probability vs. loss probability	1.23	1.11	+0.12
Calmar ratio: Return relative to maximum drawdown	2.02	1.05	+0.98
Martin ratio: Return relative to average drawdown	3.31	2.06	+1.25

GHRS vs. PFE - Sharpe Ratio Comparison

The current GHRS Sharpe Ratio is 1.02, which is higher than the PFE Sharpe Ratio of 0.50. The chart below compares the historical Sharpe Ratios of GHRS and PFE, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

GHRS vs. PFE - Drawdown Comparison

The maximum GHRS drawdown since its inception was -81.15%, which is greater than PFE's maximum drawdown of -69.24%. Use the drawdown chart below to compare losses from any high point for GHRS and PFE.

Drawdown Indicators

	GHRS	PFE	Difference
Max Drawdown Largest peak-to-trough decline	-81.15%	-69.24%	-11.91%
Max Drawdown (1Y) Largest decline over 1 year	-39.49%	-11.47%	-28.02%
Max Drawdown (3Y) Largest decline over 3 years	-62.83%	-37.69%	-25.14%
Max Drawdown (5Y) Largest decline over 5 years	—	-58.96%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-58.96%	—
Current Drawdown Current decline from peak	-20.82%	-48.02%	+27.20%
Average Drawdown Average peak-to-trough decline	-52.61%	-22.91%	-29.70%
Ulcer Index Depth and duration of drawdowns from previous peaks	24.09%	5.80%	+18.29%

Volatility

GHRS vs. PFE - Volatility Comparison

GH Research PLC (GHRS) has a higher volatility of 18.92% compared to Pfizer Inc. (PFE) at 5.40%. This indicates that GHRS's price experiences larger fluctuations and is considered to be riskier than PFE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GHRS	PFE	Difference
Volatility (1M) Calculated over the trailing 1-month period	18.92%	5.40%	+13.52%
Volatility (6M) Calculated over the trailing 6-month period	56.21%	14.21%	+42.00%
Volatility (1Y) Calculated over the trailing 1-year period	78.16%	23.93%	+54.23%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	86.82%	25.50%	+61.32%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	86.82%	23.91%	+62.91%

Dividends

GHRS vs. PFE - Dividend Comparison

GHRS has not paid dividends to shareholders, while PFE's dividend yield for the trailing twelve months is around 6.86%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
GHRS GH Research PLC	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
PFE Pfizer Inc.	6.86%	6.91%	6.33%	5.70%	3.12%	2.64%	3.92%	3.68%	3.12%	3.53%	3.69%	3.47%

Financials

Frequently Asked Questions

Can I hold both GHRS and PFE in my portfolio?

GHRS and PFE have a correlation of 0.13, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, GHRS or PFE?

GHRS has higher volatility (18.92%) compared to PFE (5.40%). In terms of maximum drawdown, GHRS dropped -81.15% vs PFE's -69.24%.

Which has better risk-adjusted returns?

GHRS currently has the higher Sharpe Ratio (1.02 vs 0.50), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.