PFE vs. MRNA

Last updated Apr 1, 2026

Compare and contrast key facts about Pfizer Inc. (PFE) and Moderna, Inc. (MRNA).

Performance

PFE vs. MRNA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Pfizer Inc. (PFE) and Moderna, Inc. (MRNA). The values are adjusted to include any dividend payments, if applicable.

PFE vs. MRNA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
PFE Pfizer Inc.	14.66%	0.65%	-2.22%	-41.26%	-10.41%	66.70%	3.07%	-6.91%	-0.61%
MRNA Moderna, Inc.	72.26%	-29.08%	-58.19%	-44.63%	-29.28%	143.11%	434.10%	28.09%	-17.90%

Fundamentals

Market Cap PFE : $159.66B MRNA : $19.91B
EPS PFE : $1.36 MRNA : -$7.24
PS Ratio PFE : 2.56 MRNA : 10.20
PB Ratio PFE : 1.72 MRNA : 2.30
Total Revenue (TTM) PFE : $62.58B MRNA : $1.94B
Gross Profit (TTM) PFE : $44.01B MRNA : $274.00M
EBITDA (TTM) PFE : $15.10B MRNA : -$2.61B

Returns By Period

In the year-to-date period, PFE achieves a 14.66% return, which is significantly lower than MRNA's 72.26% return.

PFE

• 1D: 1.12%
• 1M: 1.56%
• YTD: 14.66%
• 6M: 14.02%
• 1Y: 18.86%
• 3Y*: -6.22%
• 5Y*: -0.14%
• 10Y*: 4.32%

MRNA

• 1D: 5.33%
• 1M: -5.17%
• YTD: 72.26%
• 6M: 96.67%
• 1Y: 79.19%
• 3Y*: -30.84%
• 5Y*: -17.45%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PFE vs. MRNA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PFE

PFE Risk / Return Rank: 65
PFE Sharpe Ratio Rank: 67
PFE Sortino Ratio Rank: 61
PFE Omega Ratio Rank: 59
PFE Calmar Ratio Rank: 69
PFE Martin Ratio Rank: 69

MRNA

MRNA Risk / Return Rank: 76
MRNA Sharpe Ratio Rank: 80
MRNA Sortino Ratio Rank: 78
MRNA Omega Ratio Rank: 73
MRNA Calmar Ratio Rank: 76
MRNA Martin Ratio Rank: 72

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PFE vs. MRNA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Pfizer Inc. (PFE) and Moderna, Inc. (MRNA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PFE	MRNA	Difference
Sharpe ratio Return per unit of total volatility	0.71	1.20	-0.49
Sortino ratio Return per unit of downside risk	1.17	1.95	-0.78
Omega ratio Gain probability vs. loss probability	1.15	1.23	-0.08
Calmar ratio Return relative to maximum drawdown	1.32	1.78	-0.47
Martin ratio Return relative to average drawdown	3.18	3.67	-0.49
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PFE vs. MRNA - Sharpe Ratio Comparison

The current PFE Sharpe Ratio is 0.71, which is lower than the MRNA Sharpe Ratio of 1.20. The chart below compares the historical Sharpe Ratios of PFE and MRNA, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PFE	MRNA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.71	1.20	-0.49
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.01	-0.26	+0.26
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.18	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.26	0.20	+0.06

Correlation

The correlation between PFE and MRNA is 0.31, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PFE vs. MRNA - Dividend Comparison

PFE's dividend yield for the trailing twelve months is around 6.13%, while MRNA has not paid dividends to shareholders.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PFE Pfizer Inc.	6.13%	6.91%	6.33%	5.70%	3.12%	2.64%	3.92%	3.68%	3.12%	3.53%	3.69%	3.47%
MRNA Moderna, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Drawdowns

PFE vs. MRNA - Drawdown Comparison

The maximum PFE drawdown since its inception was -58.96%, smaller than the maximum MRNA drawdown of -95.38%. Use the drawdown chart below to compare losses from any high point for PFE and MRNA.

Drawdown Indicators

	PFE	MRNA	Difference
Max Drawdown Largest peak-to-trough decline	-58.96%	-95.38%	+36.42%
Max Drawdown (1Y) Largest decline over 1 year	-12.59%	-35.51%	+22.92%
Max Drawdown (5Y) Largest decline over 5 years	-58.96%	-95.38%	+36.42%
Max Drawdown (10Y) Largest decline over 10 years	-58.96%	—	—
Current Drawdown Current decline from peak	-42.75%	-89.51%	+46.76%
Average Drawdown Average peak-to-trough decline	-17.33%	-55.85%	+38.52%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.13%	17.25%	-11.12%

Volatility

PFE vs. MRNA - Volatility Comparison

The current volatility for Pfizer Inc. (PFE) is 6.75%, while Moderna, Inc. (MRNA) has a volatility of 23.00%. This indicates that PFE experiences smaller price fluctuations and is considered to be less risky than MRNA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PFE	MRNA	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.75%	23.00%	-16.25%
Volatility (6M) Calculated over the trailing 6-month period	18.50%	50.92%	-32.42%
Volatility (1Y) Calculated over the trailing 1-year period	26.73%	67.01%	-40.28%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.46%	66.59%	-41.13%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	23.90%	72.30%	-48.40%

Financials