EWTX vs. SPRY

Last updated Jul 15, 2026

EWTX (Edgewise Therapeutics Inc) and SPRY (Silverback Therapeutics Inc) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, EWTX returned 12.98%/yr vs -24.00%/yr for SPRY. At a 0.26 correlation, their price movements are largely independent.

Performance

EWTX vs. SPRY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Edgewise Therapeutics Inc (EWTX) and Silverback Therapeutics Inc (SPRY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, EWTX achieves a 60.10% return, which is significantly higher than SPRY's -34.68% return.

EWTX

• 1D: -3.73%
• 1M: 14.07%
• 6M: 59.24%
• YTD: 60.10%
• 1Y: 185.21%
• 3Y*: 76.55%
• 5Y*: 12.98%
• 10Y*: —

SPRY

• 1D: -1.68%
• 1M: -22.03%
• 6M: -32.71%
• YTD: -34.68%
• 1Y: -57.49%
• 3Y*: 3.67%
• 5Y*: -24.00%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

EWTX vs. SPRY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
EWTX Edgewise Therapeutics Inc	60.10%	-7.06%	144.06%	22.37%	-41.49%	-43.41%
SPRY Silverback Therapeutics Inc	-34.68%	10.43%	92.52%	-35.76%	28.08%	-86.68%

Correlation

The correlation between EWTX and SPRY is 0.27, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.27
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.27
Correlation (All Time) Calculated using the full available price history since Mar 26, 2021	0.26

Fundamentals

Market Cap EWTX : $4.27B SPRY : $755.70M
EPS EWTX : -$1.67 SPRY : -$2.00
PB Ratio EWTX : 8.63 SPRY : 12.33
Total Revenue (TTM) EWTX : $0.00 SPRY : $98.99M
Gross Profit (TTM) EWTX : $0.00 SPRY : $59.93M
EBITDA (TTM) EWTX : -$188.16M SPRY : -$194.60M

Return for Risk

EWTX vs. SPRY — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

EWTX

EWTX Risk / Return Rank: 95
EWTX Sharpe Ratio Rank: 95
EWTX Sortino Ratio Rank: 94
EWTX Omega Ratio Rank: 91
EWTX Calmar Ratio Rank: 98
EWTX Martin Ratio Rank: 98

SPRY

SPRY Risk / Return Rank: 11
SPRY Sharpe Ratio Rank: 10
SPRY Sortino Ratio Rank: 11
SPRY Omega Ratio Rank: 12
SPRY Calmar Ratio Rank: 7
SPRY Martin Ratio Rank: 15

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

EWTX vs. SPRY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Edgewise Therapeutics Inc (EWTX) and Silverback Therapeutics Inc (SPRY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	EWTX	SPRY	Difference
Sharpe ratio: Return per unit of total volatility	2.46	-0.82	+3.28
Sortino ratio: Return per unit of downside risk	3.32	-1.18	+4.50
Omega ratio: Gain probability vs. loss probability	1.39	0.86	+0.53
Calmar ratio: Return relative to maximum drawdown	9.52	-0.91	+10.43
Martin ratio: Return relative to average drawdown	24.82	-1.24	+26.06

EWTX vs. SPRY - Sharpe Ratio Comparison

The current EWTX Sharpe Ratio is 2.46, which is higher than the SPRY Sharpe Ratio of -0.82. The chart below compares the historical Sharpe Ratios of EWTX and SPRY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

EWTX vs. SPRY - Drawdown Comparison

The maximum EWTX drawdown since its inception was -84.69%, smaller than the maximum SPRY drawdown of -95.20%. Use the drawdown chart below to compare losses from any high point for EWTX and SPRY.

Drawdown Indicators

	EWTX	SPRY	Difference
Max Drawdown Largest peak-to-trough decline	-84.69%	-95.20%	+10.51%
Max Drawdown (1Y) Largest decline over 1 year	-19.59%	-63.32%	+43.73%
Max Drawdown (3Y) Largest decline over 3 years	-68.81%	-63.32%	-5.49%
Max Drawdown (5Y) Largest decline over 5 years	-75.41%	-91.77%	+16.36%
Current Drawdown Current decline from peak	-17.83%	-87.40%	+69.57%
Average Drawdown Average peak-to-trough decline	-52.76%	-78.34%	+25.58%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.51%	46.35%	-38.84%

Volatility

EWTX vs. SPRY - Volatility Comparison

The current volatility for Edgewise Therapeutics Inc (EWTX) is 21.68%, while Silverback Therapeutics Inc (SPRY) has a volatility of 31.30%. This indicates that EWTX experiences smaller price fluctuations and is considered to be less risky than SPRY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	EWTX	SPRY	Difference
Volatility (1M) Calculated over the trailing 1-month period	21.68%	31.30%	-9.62%
Volatility (6M) Calculated over the trailing 6-month period	45.27%	49.92%	-4.65%
Volatility (1Y) Calculated over the trailing 1-year period	75.84%	70.33%	+5.51%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	81.63%	80.62%	+1.01%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	81.11%	81.23%	-0.12%

Dividends

EWTX vs. SPRY - Dividend Comparison

Neither EWTX nor SPRY has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both EWTX and SPRY in my portfolio?

EWTX and SPRY have a correlation of 0.27, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, EWTX or SPRY?

SPRY has higher volatility (31.30%) compared to EWTX (21.68%). In terms of maximum drawdown, EWTX dropped -84.69% vs SPRY's -95.20%.

Which has better risk-adjusted returns?

EWTX currently has the higher Sharpe Ratio (2.46 vs -0.82), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.