CANC vs. SPAQ

Last updated Jun 4, 2026

CANC (Tema Oncology ETF) and SPAQ (Horizon Kinetics SPAC Active ETF) are both Health & Biotech Equities funds. Both are actively managed. Over the past 3 years, CANC returned 107.76%/yr vs 5.87%/yr for SPAQ. At a 0.00 correlation, their price movements are largely independent. CANC charges 0.75%/yr vs 0.85%/yr for SPAQ.

Performance

CANC vs. SPAQ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tema Oncology ETF (CANC) and Horizon Kinetics SPAC Active ETF (SPAQ). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CANC achieves a 4.82% return, which is significantly higher than SPAQ's 2.81% return.

CANC

• 1D: 0.08%
• 1M: -3.73%
• YTD: 4.82%
• 6M: 3.86%
• 1Y: 47.37%
• 3Y*: 107.76%
• 5Y*: —
• 10Y*: —

SPAQ

• 1D: 0.00%
• 1M: 1.51%
• YTD: 2.81%
• 6M: 1.64%
• 1Y: 4.98%
• 3Y*: 5.87%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CANC vs. SPAQ - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
CANC Tema Oncology ETF	4.82%	42.92%	-5.37%	462.65%
SPAQ Horizon Kinetics SPAC Active ETF	2.81%	7.35%	4.33%	5.52%

Correlation

The correlation between CANC and SPAQ is 0.01, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.01
Correlation (3Y) Calculated over the trailing 3-year period	-0.00
Correlation (All Time) Calculated using the full available price history since Jan 31, 2023	0.00

CANC vs. SPAQ - Sectors Allocation Comparison

Sectors	CANC	SPAQ
Healthcare	100.0%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	91.6%
Industrials	-	0.1%
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

CANC vs. SPAQ — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CANC

CANC Risk / Return Rank: 69
CANC Sharpe Ratio Rank: 61
CANC Sortino Ratio Rank: 64
CANC Omega Ratio Rank: 54
CANC Calmar Ratio Rank: 90
CANC Martin Ratio Rank: 77

SPAQ

SPAQ Risk / Return Rank: 20
SPAQ Sharpe Ratio Rank: 18
SPAQ Sortino Ratio Rank: 17
SPAQ Omega Ratio Rank: 20
SPAQ Calmar Ratio Rank: 21
SPAQ Martin Ratio Rank: 25

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CANC vs. SPAQ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tema Oncology ETF (CANC) and Horizon Kinetics SPAC Active ETF (SPAQ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CANC	SPAQ	Difference
Sharpe ratio: Return per unit of total volatility	2.06	0.57	+1.49
Sortino ratio: Return per unit of downside risk	2.96	0.84	+2.12
Omega ratio: Gain probability vs. loss probability	1.34	1.13	+0.21
Calmar ratio: Return relative to maximum drawdown	5.49	0.94	+4.54
Martin ratio: Return relative to average drawdown	14.62	3.39	+11.23
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CANC vs. SPAQ - Sharpe Ratio Comparison

The current CANC Sharpe Ratio is 2.06, which is higher than the SPAQ Sharpe Ratio of 0.57. The chart below compares the historical Sharpe Ratios of CANC and SPAQ, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CANC	SPAQ	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.06	0.57	+1.49
Sharpe Ratio (All Time) Calculated using the full available price history	-0.04	0.86	-0.90

Drawdowns

CANC vs. SPAQ - Drawdown Comparison

The maximum CANC drawdown since its inception was -97.53%, which is greater than SPAQ's maximum drawdown of -5.30%. Use the drawdown chart below to compare losses from any high point for CANC and SPAQ.

Drawdown Indicators

	CANC	SPAQ	Difference
Max Drawdown Largest peak-to-trough decline	-97.53%	-5.30%	-92.23%
Max Drawdown (1Y) Largest decline over 1 year	-8.67%	-5.30%	-3.37%
Max Drawdown (3Y) Largest decline over 3 years	-30.27%	-5.30%	-24.97%
Current Drawdown Current decline from peak	-56.55%	-0.01%	-56.54%
Average Drawdown Average peak-to-trough decline	-73.19%	-0.54%	-72.65%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.25%	1.47%	+1.78%

Volatility

CANC vs. SPAQ - Volatility Comparison

Tema Oncology ETF (CANC) has a higher volatility of 6.26% compared to Horizon Kinetics SPAC Active ETF (SPAQ) at 1.95%. This indicates that CANC's price experiences larger fluctuations and is considered to be riskier than SPAQ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CANC	SPAQ	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.26%	1.95%	+4.31%
Volatility (6M) Calculated over the trailing 6-month period	16.69%	5.01%	+11.68%
Volatility (1Y) Calculated over the trailing 1-year period	23.11%	8.80%	+14.31%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	280.27%	7.00%	+273.27%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	280.27%	7.00%	+273.27%

CANC vs. SPAQ - Expense Ratio Comparison

CANC has a 0.75% expense ratio, which is lower than SPAQ's 0.85% expense ratio.

Dividends

CANC vs. SPAQ - Dividend Comparison

CANC's dividend yield for the trailing twelve months is around 0.05%, less than SPAQ's 16.23% yield.

Position	TTM	2025	2024	2023
CANC Tema Oncology ETF	0.05%	0.06%	3.00%	0.56%
SPAQ Horizon Kinetics SPAC Active ETF	16.23%	16.69%	3.00%	2.60%

Frequently Asked Questions

Can I hold both CANC and SPAQ in my portfolio?

CANC and SPAQ have a correlation of 0.01, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CANC or SPAQ?

CANC has higher volatility (6.26%) compared to SPAQ (1.95%). In terms of maximum drawdown, CANC dropped -97.53% vs SPAQ's -5.30%.

Which ETF is better, CANC or SPAQ?

On 3-year performance, CANC leads with 107.76% vs 5.87% for SPAQ. On fees, CANC is cheaper at 0.75% per year. On volatility, SPAQ has been the lower-risk option at 1.95%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, CANC or SPAQ?

Over the 3-year period, CANC has performed better with a 107.76% return vs 5.87%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, CANC or SPAQ?

CANC is cheaper with a 0.75% expense ratio, compared with 0.85% for SPAQ.

Which ETF pays a higher dividend yield, CANC or SPAQ?

SPAQ has the higher dividend yield at 16.23%, compared with 0.05% for CANC.

What is the main difference between CANC and SPAQ?

They also come from different issuers: Tema and Horizon. Their fees differ too: 0.75% for CANC and 0.85% for SPAQ.

Which has better risk-adjusted returns?

CANC currently has the higher Sharpe Ratio (2.06 vs 0.57), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.