ASPI vs. AYTU

Last updated Jun 4, 2026

ASPI (ASP Isotopes Inc. Common Stock) and AYTU (Aytu BioPharma, Inc.) are both stocks. ASPI operates in Chemicals (Basic Materials), while AYTU operates in Drug Manufacturers - Specialty & Generic (Healthcare). Over the past 3 years, ASPI returned 175.06%/yr vs 4.72%/yr for AYTU. At a 0.07 correlation, their price movements are largely independent.

Performance

ASPI vs. AYTU - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ASP Isotopes Inc. Common Stock (ASPI) and Aytu BioPharma, Inc. (AYTU). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ASPI achieves a 41.12% return, which is significantly higher than AYTU's -19.62% return.

ASPI

• 1D: -9.36%
• 1M: 46.32%
• YTD: 41.12%
• 6M: 31.76%
• 1Y: -4.79%
• 3Y*: 175.06%
• 5Y*: —
• 10Y*: —

AYTU

• 1D: -0.48%
• 1M: -18.04%
• YTD: -19.62%
• 6M: -1.88%
• 1Y: 34.84%
• 3Y*: 4.72%
• 5Y*: -54.43%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ASPI vs. AYTU - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
ASPI ASP Isotopes Inc. Common Stock	41.12%	18.10%	153.07%	13.29%	-40.82%
AYTU Aytu BioPharma, Inc.	-19.62%	52.94%	-40.14%	-24.87%	18.42%

Correlation

The correlation between ASPI and AYTU is 0.22, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.22
Correlation (3Y) Calculated over the trailing 3-year period	0.05
Correlation (All Time) Calculated using the full available price history since Nov 11, 2022	0.07

The correlation between ASPI and AYTU shifts across timeframes, from 0.05 (3 years) to 0.22 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ASPI : $706.81M AYTU : $21.97M
EPS ASPI : -$2.06 AYTU : -$2.91
PS Ratio ASPI : 26.93 AYTU : 0.43
PB Ratio ASPI : 3.46 AYTU : 0.63
Total Revenue (TTM) ASPI : $23.85M AYTU : $56.60M
Gross Profit (TTM) ASPI : $2.47M AYTU : $36.14M
EBITDA (TTM) ASPI : -$118.78M AYTU : -$27.34M

Return for Risk

ASPI vs. AYTU — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ASPI

ASPI Risk / Return Rank: 42
ASPI Sharpe Ratio Rank: 39
ASPI Sortino Ratio Rank: 49
ASPI Omega Ratio Rank: 45
ASPI Calmar Ratio Rank: 38
ASPI Martin Ratio Rank: 38

AYTU

AYTU Risk / Return Rank: 60
AYTU Sharpe Ratio Rank: 59
AYTU Sortino Ratio Rank: 60
AYTU Omega Ratio Rank: 60
AYTU Calmar Ratio Rank: 61
AYTU Martin Ratio Rank: 62

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ASPI vs. AYTU - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ASP Isotopes Inc. Common Stock (ASPI) and Aytu BioPharma, Inc. (AYTU). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ASPI	AYTU	Difference
Sharpe ratio Return per unit of total volatility	-0.04	0.54	-0.58
Sortino ratio Return per unit of downside risk	0.77	1.29	-0.52
Omega ratio Gain probability vs. loss probability	1.08	1.16	-0.08
Calmar ratio Return relative to maximum drawdown	-0.07	0.99	-1.05
Martin ratio Return relative to average drawdown	-0.11	2.38	-2.48
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ASPI vs. AYTU - Sharpe Ratio Comparison

The current ASPI Sharpe Ratio is -0.04, which is lower than the AYTU Sharpe Ratio of 0.54. The chart below compares the historical Sharpe Ratios of ASPI and AYTU, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ASPI	AYTU	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.04	0.54	-0.58
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.64	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.31	-0.36	+0.67

Drawdowns

ASPI vs. AYTU - Drawdown Comparison

The maximum ASPI drawdown since its inception was -88.57%, smaller than the maximum AYTU drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for ASPI and AYTU.

Drawdown Indicators

	ASPI	AYTU	Difference
Max Drawdown Largest peak-to-trough decline	-88.57%	-100.00%	+11.43%
Max Drawdown (1Y) Largest decline over 1 year	-71.03%	-35.47%	-35.56%
Max Drawdown (3Y) Largest decline over 3 years	-71.03%	-70.24%	-0.79%
Max Drawdown (5Y) Largest decline over 5 years	—	-99.12%	—
Current Drawdown Current decline from peak	-46.26%	-100.00%	+53.74%
Average Drawdown Average peak-to-trough decline	-41.69%	-95.14%	+53.45%
Ulcer Index Depth and duration of drawdowns from previous peaks	45.53%	14.70%	+30.83%

Volatility

ASPI vs. AYTU - Volatility Comparison

ASP Isotopes Inc. Common Stock (ASPI) has a higher volatility of 39.04% compared to Aytu BioPharma, Inc. (AYTU) at 12.46%. This indicates that ASPI's price experiences larger fluctuations and is considered to be riskier than AYTU based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ASPI	AYTU	Difference
Volatility (1M) Calculated over the trailing 1-month period	39.04%	12.46%	+26.58%
Volatility (6M) Calculated over the trailing 6-month period	73.84%	33.42%	+40.42%
Volatility (1Y) Calculated over the trailing 1-year period	108.47%	66.08%	+42.39%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	112.09%	85.63%	+26.46%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	112.09%	188.31%	-76.22%

Dividends

ASPI vs. AYTU - Dividend Comparison

Neither ASPI nor AYTU has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ASPI and AYTU in my portfolio?

ASPI and AYTU have a correlation of 0.22, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ASPI or AYTU?

ASPI has higher volatility (39.04%) compared to AYTU (12.46%). In terms of maximum drawdown, ASPI dropped -88.57% vs AYTU's -100.00%.

Which has better risk-adjusted returns?

AYTU currently has the higher Sharpe Ratio (0.54 vs -0.04), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.