ASND vs. TGTX

Last updated Aug 1, 2026

ASND (Ascendis Pharma A/S) and TGTX (TG Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, ASND returned 33.00%/yr vs 24.71%/yr for TGTX. Their 0.28 correlation means their historical movements had little consistent relationship.

Performance

ASND vs. TGTX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Ascendis Pharma A/S (ASND) and TG Therapeutics, Inc. (TGTX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ASND achieves a 14.38% return, which is significantly lower than TGTX's 74.54% return. Over the past 10 years, ASND has outperformed TGTX with an annualized return of 33.00%, while TGTX has yielded a comparatively lower 24.71% annualized return.

ASND

• 1D: -2.85%
• 1M: -11.14%
• 6M: 7.88%
• YTD: 14.38%
• 1Y: 39.79%
• 3Y*: 38.59%
• 5Y*: 15.59%
• 10Y*: 33.00%
• ALL TIME*: 23.51%

TGTX

• 1D: -2.80%
• 1M: -2.40%
• 6M: 76.79%
• YTD: 74.54%
• 1Y: 48.57%
• 3Y*: 70.54%
• 5Y*: 8.26%
• 10Y*: 24.71%
• ALL TIME*: -7.87%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
ASND Ascendis Pharma A/S	$116.18M	$134.94M	$171.37M
TGTX TG Therapeutics, Inc.	$111.05M	$115.82M	$119.77M

ASND vs. TGTX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ASND Ascendis Pharma A/S	14.38%	54.89%	9.31%	3.13%	-9.22%	-19.34%	19.88%	122.06%	56.39%	97.92%
TGTX TG Therapeutics, Inc.	74.54%	-0.96%	76.23%	44.38%	-37.74%	-63.48%	368.65%	170.73%	-50.00%	76.34%

Correlation

The correlation between ASND and TGTX is 0.26, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.26
Correlation (3Y) Balances recent behavior with more history.	0.26
Correlation (5Y) Shows whether the relationship held over a longer period.	0.33
Correlation (10Y) Provides a long-term view across more market conditions.	0.29
Correlation (All Time) Calculated using the full available price history since Jan 28, 2015	0.28

Fundamentals

Market Cap ASND : $15.15B TGTX : $7.96B
EPS ASND : €8.13 TGTX : $2.88
PE Ratio ASND : 26.01 TGTX : 18.04
PEG Ratio ASND : 0.12 TGTX : 0.03
PS Ratio ASND : 15.19 TGTX : 11.90
PB Ratio ASND : 27.94 TGTX : 14.28
Total Revenue (TTM) ASND : €867.51M TGTX : $700.35M
Gross Profit (TTM) ASND : €764.89M TGTX : $581.54M
EBITDA (TTM) ASND : -€6.94M TGTX : $156.88M

Return for Risk

ASND vs. TGTX — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

ASND

ASND Risk / Return Rank: 78
ASND Sharpe Ratio Rank: 78
ASND Sortino Ratio Rank: 75
ASND Omega Ratio Rank: 72
ASND Calmar Ratio Rank: 82
ASND Martin Ratio Rank: 85

TGTX

TGTX Risk / Return Rank: 74
TGTX Sharpe Ratio Rank: 76
TGTX Sortino Ratio Rank: 73
TGTX Omega Ratio Rank: 73
TGTX Calmar Ratio Rank: 77
TGTX Martin Ratio Rank: 73

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

ASND vs. TGTX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Ascendis Pharma A/S (ASND) and TG Therapeutics, Inc. (TGTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ASND	TGTX	Difference
Sharpe ratio: Return per unit of total volatility	1.09	0.99	+0.10
Sortino ratio: Return per unit of downside risk	1.72	1.64	+0.08
Omega ratio: Gain probability vs. loss probability	1.20	1.21	-0.01
Calmar ratio: Return relative to maximum drawdown	2.35	1.74	+0.60
Martin ratio: Return relative to average drawdown	6.86	3.46	+3.40

ASND vs. TGTX - Sharpe Ratio Comparison

The current ASND Sharpe Ratio is 1.09, which is comparable to the TGTX Sharpe Ratio of 0.99. The chart below compares the historical Sharpe Ratios of ASND and TGTX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ASND vs. TGTX - Drawdown Comparison

The maximum ASND drawdown since its inception was -61.72%, smaller than the maximum TGTX drawdown of -99.52%. Use the drawdown chart below to compare losses from any high point for ASND and TGTX.

Drawdown Indicators

	ASND	TGTX	Difference
Max Drawdown Largest peak-to-trough decline	-61.72%	-99.52%	+37.80%
Max Drawdown (1Y) Largest decline over 1 year	-17.62%	-26.85%	+9.23%
Max Drawdown (3Y) Largest decline over 3 years	-29.15%	-42.06%	+12.91%
Max Drawdown (5Y) Largest decline over 5 years	-60.46%	-89.47%	+29.01%
Max Drawdown (10Y) Largest decline over 10 years	-61.72%	-93.19%	+31.47%
Current Drawdown Current decline from peak	-12.00%	-77.71%	+65.71%
Average Drawdown Average peak-to-trough decline	-18.75%	-91.31%	+72.56%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.98%	13.66%	-7.68%

Volatility

ASND vs. TGTX - Volatility Comparison

The current volatility for Ascendis Pharma A/S (ASND) is 8.48%, while TG Therapeutics, Inc. (TGTX) has a volatility of 12.23%. This indicates that ASND experiences smaller price fluctuations and is considered to be less risky than TGTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ASND	TGTX	Difference
Volatility (1M) Calculated over the trailing 1-month period	8.48%	12.23%	-3.75%
Volatility (6M) Calculated over the trailing 6-month period	28.54%	33.96%	-5.42%
Volatility (1Y) Calculated over the trailing 1-year period	38.24%	47.22%	-8.98%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	48.85%	87.68%	-38.83%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	51.04%	86.71%	-35.67%

Dividends

ASND vs. TGTX - Dividend Comparison

Neither ASND nor TGTX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ASND and TGTX in my portfolio?

ASND and TGTX have a correlation of 0.26, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ASND or TGTX?

TGTX has higher volatility (12.23%) compared to ASND (8.48%). In terms of maximum drawdown, ASND dropped -61.72% vs TGTX's -99.52%.

Which has better risk-adjusted returns?

ASND currently has the higher Sharpe Ratio (1.09 vs 0.99), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.