ASND vs. TGTX

Last updated Apr 1, 2026

Compare and contrast key facts about Ascendis Pharma A/S (ASND) and TG Therapeutics, Inc. (TGTX).

Performance

ASND vs. TGTX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Ascendis Pharma A/S (ASND) and TG Therapeutics, Inc. (TGTX). The values are adjusted to include any dividend payments, if applicable.

ASND vs. TGTX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ASND Ascendis Pharma A/S	7.26%	54.89%	9.31%	3.13%	-9.22%	-19.34%	19.88%	122.06%	56.39%	97.92%
TGTX TG Therapeutics, Inc.	11.44%	-0.96%	76.23%	44.38%	-37.74%	-63.48%	368.65%	170.73%	-50.00%	76.34%

Fundamentals

EPS ASND : -$3.67 TGTX : $2.77
PS Ratio ASND : 19.79 TGTX : 10.10
Total Revenue (TTM) ASND : $717.81M TGTX : $531.90M
Gross Profit (TTM) ASND : $619.30M TGTX : $453.87M
EBITDA (TTM) ASND : -$80.69M TGTX : $115.24M

Returns By Period

In the year-to-date period, ASND achieves a 7.26% return, which is significantly lower than TGTX's 11.44% return. Over the past 10 years, ASND has outperformed TGTX with an annualized return of 28.43%, while TGTX has yielded a comparatively lower 14.00% annualized return.

ASND

• 1D: 4.75%
• 1M: -2.04%
• YTD: 7.26%
• 6M: 15.05%
• 1Y: 46.75%
• 3Y*: 28.73%
• 5Y*: 11.89%
• 10Y*: 28.43%

TGTX

• 1D: 5.43%
• 1M: 10.40%
• YTD: 11.44%
• 6M: -8.04%
• 1Y: -15.75%
• 3Y*: 30.23%
• 5Y*: -7.46%
• 10Y*: 14.00%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

ASND vs. TGTX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ASND

ASND Risk / Return Rank: 82
ASND Sharpe Ratio Rank: 81
ASND Sortino Ratio Rank: 77
ASND Omega Ratio Rank: 72
ASND Calmar Ratio Rank: 90
ASND Martin Ratio Rank: 88

TGTX

TGTX Risk / Return Rank: 28
TGTX Sharpe Ratio Rank: 26
TGTX Sortino Ratio Rank: 26
TGTX Omega Ratio Rank: 26
TGTX Calmar Ratio Rank: 29
TGTX Martin Ratio Rank: 33

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ASND vs. TGTX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Ascendis Pharma A/S (ASND) and TG Therapeutics, Inc. (TGTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ASND	TGTX	Difference
Sharpe ratio Return per unit of total volatility	1.29	-0.34	+1.63
Sortino ratio Return per unit of downside risk	1.95	-0.18	+2.13
Omega ratio Gain probability vs. loss probability	1.23	0.98	+0.25
Calmar ratio Return relative to maximum drawdown	3.96	-0.40	+4.35
Martin ratio Return relative to average drawdown	9.47	-0.60	+10.07
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ASND vs. TGTX - Sharpe Ratio Comparison

The current ASND Sharpe Ratio is 1.29, which is higher than the TGTX Sharpe Ratio of -0.34. The chart below compares the historical Sharpe Ratios of ASND and TGTX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	ASND	TGTX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.29	-0.34	+1.63
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.25	-0.09	+0.33
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.56	0.16	+0.39
Sharpe Ratio (All Time) Calculated using the full available price history	0.49	-0.05	+0.55

Correlation

The correlation between ASND and TGTX is 0.28, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

ASND vs. TGTX - Dividend Comparison

Neither ASND nor TGTX has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

ASND vs. TGTX - Drawdown Comparison

The maximum ASND drawdown since its inception was -61.72%, smaller than the maximum TGTX drawdown of -99.52%. Use the drawdown chart below to compare losses from any high point for ASND and TGTX.

Drawdown Indicators

	ASND	TGTX	Difference
Max Drawdown Largest peak-to-trough decline	-61.72%	-99.52%	+37.80%
Max Drawdown (1Y) Largest decline over 1 year	-12.09%	-42.01%	+29.92%
Max Drawdown (5Y) Largest decline over 5 years	-60.46%	-92.36%	+31.90%
Max Drawdown (10Y) Largest decline over 10 years	-61.72%	-93.19%	+31.47%
Current Drawdown Current decline from peak	-5.52%	-85.77%	+80.25%
Average Drawdown Average peak-to-trough decline	-18.90%	-91.55%	+72.65%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.06%	27.97%	-22.91%

Volatility

ASND vs. TGTX - Volatility Comparison

The current volatility for Ascendis Pharma A/S (ASND) is 9.38%, while TG Therapeutics, Inc. (TGTX) has a volatility of 15.21%. This indicates that ASND experiences smaller price fluctuations and is considered to be less risky than TGTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ASND	TGTX	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.38%	15.21%	-5.83%
Volatility (6M) Calculated over the trailing 6-month period	26.45%	28.18%	-1.73%
Volatility (1Y) Calculated over the trailing 1-year period	36.54%	46.37%	-9.83%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	48.36%	87.52%	-39.16%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	51.28%	86.94%	-35.66%

Financials