ANRO vs. AG

Last updated Jun 3, 2026

ANRO (Alto Neuroscience, Inc) and AG (First Majestic Silver Corp.) are both stocks. ANRO operates in Biotechnology (Healthcare), while AG operates in Silver (Basic Materials). Over the past year, ANRO returned 619.62% vs 205.74% for AG. At a 0.11 correlation, their price movements are largely independent.

Performance

ANRO vs. AG - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Alto Neuroscience, Inc (ANRO) and First Majestic Silver Corp. (AG). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ANRO achieves a 5.11% return, which is significantly lower than AG's 26.14% return.

ANRO

• 1D: -5.51%
• 1M: -24.98%
• YTD: 5.11%
• 6M: 46.17%
• 1Y: 619.62%
• 3Y*: —
• 5Y*: —
• 10Y*: —

AG

• 1D: 0.77%
• 1M: 5.84%
• YTD: 26.14%
• 6M: 32.08%
• 1Y: 205.74%
• 3Y*: 52.85%
• 5Y*: 3.97%
• 10Y*: 6.12%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ANRO vs. AG - Yearly Performance Comparison

	2026 (YTD)	2025	2024
ANRO Alto Neuroscience, Inc	5.11%	320.80%	-79.57%
AG First Majestic Silver Corp.	26.14%	204.32%	14.71%

Correlation

The correlation between ANRO and AG is 0.14, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.14
Correlation (All Time) Calculated using the full available price history since Feb 5, 2024	0.11

Fundamentals

Market Cap ANRO : $615.43M AG : $10.53B
EPS ANRO : -$2.50 AG : $0.60
PB Ratio ANRO : 2.53 AG : 3.63
Total Revenue (TTM) ANRO : $0.00 AG : $1.49B
Gross Profit (TTM) ANRO : -$421.00K AG : $646.49M
EBITDA (TTM) ANRO : -$74.36M AG : $824.25M

Return for Risk

ANRO vs. AG — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ANRO

ANRO Risk / Return Rank: 98
ANRO Sharpe Ratio Rank: 98
ANRO Sortino Ratio Rank: 97
ANRO Omega Ratio Rank: 96
ANRO Calmar Ratio Rank: 99
ANRO Martin Ratio Rank: 99

AG

AG Risk / Return Rank: 90
AG Sharpe Ratio Rank: 93
AG Sortino Ratio Rank: 88
AG Omega Ratio Rank: 86
AG Calmar Ratio Rank: 92
AG Martin Ratio Rank: 90

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ANRO vs. AG - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Alto Neuroscience, Inc (ANRO) and First Majestic Silver Corp. (AG). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ANRO	AG	Difference
Sharpe ratio Return per unit of total volatility	4.90	2.84	+2.06
Sortino ratio Return per unit of downside risk	4.98	3.02	+1.96
Omega ratio Gain probability vs. loss probability	1.62	1.38	+0.24
Calmar ratio Return relative to maximum drawdown	19.23	5.61	+13.62
Martin ratio Return relative to average drawdown	52.34	12.63	+39.71
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ANRO vs. AG - Sharpe Ratio Comparison

The current ANRO Sharpe Ratio is 4.90, which is higher than the AG Sharpe Ratio of 2.84. The chart below compares the historical Sharpe Ratios of ANRO and AG, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ANRO	AG	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	4.90	2.84	+2.06
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.07	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.10	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.04	0.05	-0.09

Drawdowns

ANRO vs. AG - Drawdown Comparison

The maximum ANRO drawdown since its inception was -91.74%, roughly equal to the maximum AG drawdown of -90.20%. Use the drawdown chart below to compare losses from any high point for ANRO and AG.

Drawdown Indicators

	ANRO	AG	Difference
Max Drawdown Largest peak-to-trough decline	-91.74%	-90.20%	-1.54%
Max Drawdown (1Y) Largest decline over 1 year	-32.50%	-42.92%	+10.42%
Max Drawdown (3Y) Largest decline over 3 years	—	-42.92%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-76.89%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-80.82%	—
Current Drawdown Current decline from peak	-32.50%	-34.37%	+1.87%
Average Drawdown Average peak-to-trough decline	-53.66%	-59.21%	+5.55%
Ulcer Index Depth and duration of drawdowns from previous peaks	11.94%	19.08%	-7.14%

Volatility

ANRO vs. AG - Volatility Comparison

The current volatility for Alto Neuroscience, Inc (ANRO) is 14.02%, while First Majestic Silver Corp. (AG) has a volatility of 21.88%. This indicates that ANRO experiences smaller price fluctuations and is considered to be less risky than AG based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ANRO	AG	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.02%	21.88%	-7.86%
Volatility (6M) Calculated over the trailing 6-month period	53.38%	55.72%	-2.34%
Volatility (1Y) Calculated over the trailing 1-year period	127.54%	73.78%	+53.76%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	115.70%	61.33%	+54.37%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	115.70%	61.82%	+53.88%

Dividends

ANRO vs. AG - Dividend Comparison

ANRO has not paid dividends to shareholders, while AG's dividend yield for the trailing twelve months is around 0.17%.

Position	TTM	2025	2024	2023	2022	2021
AG First Majestic Silver Corp.	0.17%	0.12%	0.33%	0.34%	0.31%	0.14%
ANRO Alto Neuroscience, Inc	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials

Frequently Asked Questions

Can I hold both ANRO and AG in my portfolio?

ANRO and AG have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ANRO or AG?

AG has higher volatility (21.88%) compared to ANRO (14.02%). In terms of maximum drawdown, ANRO dropped -91.74% vs AG's -90.20%.

Which has better risk-adjusted returns?

ANRO currently has the higher Sharpe Ratio (4.90 vs 2.84), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.