ACXP vs. GLSI

Last updated Aug 1, 2026

ACXP (Acurx Pharmaceuticals, Inc.) and GLSI (Greenwich LifeSciences, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, ACXP returned -58.26%/yr vs -19.31%/yr for GLSI. Their 0.17 correlation means their historical movements had little consistent relationship.

Performance

ACXP vs. GLSI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Acurx Pharmaceuticals, Inc. (ACXP) and Greenwich LifeSciences, Inc. (GLSI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACXP achieves a -42.17% return, which is significantly lower than GLSI's -35.74% return.

ACXP

• 1D: 1.41%
• 1M: -10.00%
• 6M: -39.11%
• YTD: -42.17%
• 1Y: -76.55%
• 3Y*: -66.87%
• 5Y*: -58.26%
• 10Y*: —
• ALL TIME*: -57.93%

GLSI

• 1D: -3.71%
• 1M: -38.64%
• 6M: -55.10%
• YTD: -35.74%
• 1Y: 21.73%
• 3Y*: 10.93%
• 5Y*: -19.31%
• 10Y*: —
• ALL TIME*: 15.72%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
ACXP Acurx Pharmaceuticals, Inc.	$106.69K	$141.74K	$162.46K
GLSI Greenwich LifeSciences, Inc.	$2.85M	$2.86M	$3.32M

ACXP vs. GLSI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
ACXP Acurx Pharmaceuticals, Inc.	-42.17%	-84.71%	-78.75%	-3.77%	-7.90%	-27.37%
GLSI Greenwich LifeSciences, Inc.	-35.74%	87.09%	6.75%	-30.79%	-37.53%	-44.34%

Correlation

The correlation between ACXP and GLSI is 0.20, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.20
Correlation (3Y) Balances recent behavior with more history.	0.18
Correlation (5Y) Shows whether the relationship held over a longer period.	0.17
Correlation (All Time) Calculated using the full available price history since Jun 25, 2021	0.17

Fundamentals

Market Cap ACXP : $2.28M GLSI : $198.16M
EPS ACXP : -$866.03 GLSI : -$1.56
PB Ratio ACXP : 0.00 GLSI : 37.31
Total Revenue (TTM) ACXP : $0.00 GLSI : $3.56K
Gross Profit (TTM) ACXP : $0.00 GLSI : $903.00
EBITDA (TTM) ACXP : -$5.88M GLSI : -$21.89M

Return for Risk

ACXP vs. GLSI — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

ACXP

ACXP Risk / Return Rank: 19
ACXP Sharpe Ratio Rank: 25
ACXP Sortino Ratio Rank: 26
ACXP Omega Ratio Rank: 27
ACXP Calmar Ratio Rank: 6
ACXP Martin Ratio Rank: 12

GLSI

GLSI Risk / Return Rank: 56
GLSI Sharpe Ratio Rank: 53
GLSI Sortino Ratio Rank: 61
GLSI Omega Ratio Rank: 58
GLSI Calmar Ratio Rank: 54
GLSI Martin Ratio Rank: 56

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

ACXP vs. GLSI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Acurx Pharmaceuticals, Inc. (ACXP) and Greenwich LifeSciences, Inc. (GLSI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ACXP	GLSI	Difference
Sharpe ratio: Return per unit of total volatility	-0.42	0.24	-0.66
Sortino ratio: Return per unit of downside risk	-0.30	1.08	-1.38
Omega ratio: Gain probability vs. loss probability	0.97	1.13	-0.16
Calmar ratio: Return relative to maximum drawdown	-0.94	0.38	-1.32
Martin ratio: Return relative to average drawdown	-1.29	0.89	-2.19

ACXP vs. GLSI - Sharpe Ratio Comparison

The current ACXP Sharpe Ratio is -0.42, which is lower than the GLSI Sharpe Ratio of 0.24. The chart below compares the historical Sharpe Ratios of ACXP and GLSI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ACXP vs. GLSI - Drawdown Comparison

The maximum ACXP drawdown since its inception was -99.14%, which is greater than GLSI's maximum drawdown of -90.11%. Use the drawdown chart below to compare losses from any high point for ACXP and GLSI.

Drawdown Indicators

	ACXP	GLSI	Difference
Max Drawdown Largest peak-to-trough decline	-99.14%	-90.11%	-9.03%
Max Drawdown (1Y) Largest decline over 1 year	-83.33%	-61.87%	-21.46%
Max Drawdown (3Y) Largest decline over 3 years	-98.83%	-61.87%	-36.96%
Max Drawdown (5Y) Largest decline over 5 years	-98.84%	-84.52%	-14.32%
Current Drawdown Current decline from peak	-99.09%	-81.31%	-17.78%
Average Drawdown Average peak-to-trough decline	-70.16%	-72.80%	+2.64%
Ulcer Index Depth and duration of drawdowns from previous peaks	60.56%	26.24%	+34.32%

Volatility

ACXP vs. GLSI - Volatility Comparison

The current volatility for Acurx Pharmaceuticals, Inc. (ACXP) is 20.58%, while Greenwich LifeSciences, Inc. (GLSI) has a volatility of 29.58%. This indicates that ACXP experiences smaller price fluctuations and is considered to be less risky than GLSI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACXP	GLSI	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.58%	29.58%	-9.00%
Volatility (6M) Calculated over the trailing 6-month period	120.16%	69.03%	+51.13%
Volatility (1Y) Calculated over the trailing 1-year period	185.91%	98.53%	+87.38%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	139.94%	80.02%	+59.92%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	139.84%	422.94%	-283.10%

Dividends

ACXP vs. GLSI - Dividend Comparison

Neither ACXP nor GLSI has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACXP and GLSI in my portfolio?

ACXP and GLSI have a correlation of 0.20, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACXP or GLSI?

GLSI has higher volatility (29.58%) compared to ACXP (20.58%). In terms of maximum drawdown, ACXP dropped -99.14% vs GLSI's -90.11%.

Which has better risk-adjusted returns?

GLSI currently has the higher Sharpe Ratio (0.24 vs -0.42), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.