ACXP vs. NVNO

Last updated Jun 3, 2026

ACXP (Acurx Pharmaceuticals, Inc.) and NVNO (enVVeno Medical Corporation) are both stocks. Both are in the Healthcare sector — ACXP in Biotechnology, NVNO in Medical Devices. Over the past 3 years, ACXP returned -68.65%/yr vs -54.02%/yr for NVNO. At a 0.15 correlation, their price movements are largely independent.

Performance

ACXP vs. NVNO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Acurx Pharmaceuticals, Inc. (ACXP) and enVVeno Medical Corporation (NVNO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACXP achieves a -27.71% return, which is significantly lower than NVNO's -4.26% return.

ACXP

• 1D: -6.74%
• 1M: -16.67%
• YTD: -27.71%
• 6M: -45.62%
• 1Y: -76.14%
• 3Y*: -68.65%
• 5Y*: —
• 10Y*: —

NVNO

• 1D: 0.72%
• 1M: 2.38%
• YTD: -4.26%
• 6M: -15.53%
• 1Y: -91.25%
• 3Y*: -54.02%
• 5Y*: -44.98%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ACXP vs. NVNO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
ACXP Acurx Pharmaceuticals, Inc.	-27.71%	-84.71%	-78.75%	-3.77%	-7.90%	-45.23%
NVNO enVVeno Medical Corporation	-4.26%	-89.38%	-41.25%	0.78%	-22.61%	-2.23%

Correlation

The correlation between ACXP and NVNO is 0.27, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.27
Correlation (3Y) Calculated over the trailing 3-year period	0.19
Correlation (All Time) Calculated using the full available price history since Jun 28, 2021	0.15

The correlation between ACXP and NVNO shifts across timeframes, from 0.15 (all time) to 0.27 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ACXP : $4.89M NVNO : $7.03M
EPS ACXP : -$959.29 NVNO : -$58.99
PB Ratio ACXP : 0.00 NVNO : 0.30
Total Revenue (TTM) ACXP : $0.00 NVNO : $0.00
Gross Profit (TTM) ACXP : $0.00 NVNO : -$491.00K
EBITDA (TTM) ACXP : -$5.88M NVNO : -$18.82M

Return for Risk

ACXP vs. NVNO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ACXP

ACXP Risk / Return Rank: 29
ACXP Sharpe Ratio Rank: 28
ACXP Sortino Ratio Rank: 48
ACXP Omega Ratio Rank: 44
ACXP Calmar Ratio Rank: 8
ACXP Martin Ratio Rank: 18

NVNO

NVNO Risk / Return Rank: 8
NVNO Sharpe Ratio Rank: 10
NVNO Sortino Ratio Rank: 6
NVNO Omega Ratio Rank: 4
NVNO Calmar Ratio Rank: 3
NVNO Martin Ratio Rank: 16

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ACXP vs. NVNO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Acurx Pharmaceuticals, Inc. (ACXP) and enVVeno Medical Corporation (NVNO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ACXP	NVNO	Difference
Sharpe ratio Return per unit of total volatility	-0.30	-0.76	+0.46
Sortino ratio Return per unit of downside risk	0.76	-1.39	+2.15
Omega ratio Gain probability vs. loss probability	1.08	0.77	+0.30
Calmar ratio Return relative to maximum drawdown	-0.84	-0.96	+0.12
Martin ratio Return relative to average drawdown	-1.05	-1.14	+0.08
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ACXP vs. NVNO - Sharpe Ratio Comparison

The current ACXP Sharpe Ratio is -0.30, which is higher than the NVNO Sharpe Ratio of -0.76. The chart below compares the historical Sharpe Ratios of ACXP and NVNO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ACXP	NVNO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.30	-0.76	+0.46
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.55	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.42	-0.57	+0.14

Drawdowns

ACXP vs. NVNO - Drawdown Comparison

The maximum ACXP drawdown since its inception was -99.14%, roughly equal to the maximum NVNO drawdown of -99.81%. Use the drawdown chart below to compare losses from any high point for ACXP and NVNO.

Drawdown Indicators

	ACXP	NVNO	Difference
Max Drawdown Largest peak-to-trough decline	-99.14%	-99.81%	+0.67%
Max Drawdown (1Y) Largest decline over 1 year	-91.78%	-95.28%	+3.50%
Max Drawdown (3Y) Largest decline over 3 years	-98.83%	-96.27%	-2.56%
Max Drawdown (5Y) Largest decline over 5 years	—	-97.66%	—
Current Drawdown Current decline from peak	-98.86%	-99.77%	+0.91%
Average Drawdown Average peak-to-trough decline	-69.26%	-89.96%	+20.70%
Ulcer Index Depth and duration of drawdowns from previous peaks	72.97%	80.60%	-7.63%

Volatility

ACXP vs. NVNO - Volatility Comparison

Acurx Pharmaceuticals, Inc. (ACXP) and enVVeno Medical Corporation (NVNO) have volatilities of 16.36% and 17.17%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACXP	NVNO	Difference
Volatility (1M) Calculated over the trailing 1-month period	16.36%	17.17%	-0.81%
Volatility (6M) Calculated over the trailing 6-month period	125.22%	63.17%	+62.05%
Volatility (1Y) Calculated over the trailing 1-year period	253.65%	119.70%	+133.95%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	140.88%	81.37%	+59.51%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	140.88%	93.74%	+47.14%

Dividends

ACXP vs. NVNO - Dividend Comparison

Neither ACXP nor NVNO has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACXP and NVNO in my portfolio?

ACXP and NVNO have a correlation of 0.27, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACXP or NVNO?

NVNO has higher volatility (17.17%) compared to ACXP (16.36%). In terms of maximum drawdown, ACXP dropped -99.14% vs NVNO's -99.81%.

Which has better risk-adjusted returns?

ACXP currently has the higher Sharpe Ratio (-0.30 vs -0.76), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.