XOMA vs. SPY

Last updated Jul 11, 2026

XOMA (XOMA Corporation) is a stock, while SPY (State Street SPDR S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 10 years, XOMA returned 15.11%/yr vs 15.22%/yr for SPY. At a 0.28 correlation, their price movements are largely independent.

Performance

XOMA vs. SPY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in XOMA Corporation (XOMA) and State Street SPDR S&P 500 ETF (SPY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XOMA achieves a 66.30% return, which is significantly higher than SPY's 11.30% return. Both investments have delivered pretty close results over the past 10 years, with XOMA having a 15.11% annualized return and SPY not far ahead at 15.22%.

XOMA

• 1D: -1.29%
• 1M: 5.81%
• 6M: 48.14%
• YTD: 66.30%
• 1Y: 62.93%
• 3Y*: 37.83%
• 5Y*: 5.07%
• 10Y*: 15.11%

SPY

• 1D: 0.43%
• 1M: 2.04%
• 6M: 9.35%
• YTD: 11.30%
• 1Y: 22.40%
• 3Y*: 20.99%
• 5Y*: 13.15%
• 10Y*: 15.22%

*Multi-year figures are annualized to reflect compound growth (CAGR)

XOMA vs. SPY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
XOMA XOMA Corporation	66.30%	1.18%	42.05%	0.54%	-11.75%	-52.75%	61.65%	115.81%	-64.47%	743.60%
SPY State Street SPDR S&P 500 ETF	11.30%	17.72%	24.89%	26.18%	-18.18%	28.73%	18.33%	31.22%	-4.57%	21.71%

Correlation

The correlation between XOMA and SPY is 0.28, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.28
Correlation (3Y) Calculated over the trailing 3-year period	0.25
Correlation (5Y) Calculated over the trailing 5-year period	0.25
Correlation (10Y) Calculated over the trailing 10-year period	0.26
Correlation (All Time) Calculated using the full available price history since Jan 29, 1993	0.28

Return for Risk

XOMA vs. SPY — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XOMA

XOMA Risk / Return Rank: 75
XOMA Sharpe Ratio Rank: 79
XOMA Sortino Ratio Rank: 73
XOMA Omega Ratio Rank: 79
XOMA Calmar Ratio Rank: 72
XOMA Martin Ratio Rank: 71

SPY

SPY Risk / Return Rank: 67
SPY Sharpe Ratio Rank: 68
SPY Sortino Ratio Rank: 66
SPY Omega Ratio Rank: 67
SPY Calmar Ratio Rank: 62
SPY Martin Ratio Rank: 73

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XOMA vs. SPY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for XOMA Corporation (XOMA) and State Street SPDR S&P 500 ETF (SPY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	XOMA	SPY	Difference
Sharpe ratio: Return per unit of total volatility	1.13	1.76	-0.62
Sortino ratio: Return per unit of downside risk	1.62	2.42	-0.80
Omega ratio: Gain probability vs. loss probability	1.25	1.32	-0.07
Calmar ratio: Return relative to maximum drawdown	1.39	2.48	-1.10
Martin ratio: Return relative to average drawdown	2.97	10.83	-7.86

XOMA vs. SPY - Sharpe Ratio Comparison

The current XOMA Sharpe Ratio is 1.13, which is lower than the SPY Sharpe Ratio of 1.76. The chart below compares the historical Sharpe Ratios of XOMA and SPY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

XOMA vs. SPY - Drawdown Comparison

The maximum XOMA drawdown since its inception was -99.96%, which is greater than SPY's maximum drawdown of -55.19%. Use the drawdown chart below to compare losses from any high point for XOMA and SPY.

Drawdown Indicators

	XOMA	SPY	Difference
Max Drawdown Largest peak-to-trough decline	-99.96%	-55.19%	-44.77%
Max Drawdown (1Y) Largest decline over 1 year	-42.37%	-8.88%	-33.49%
Max Drawdown (3Y) Largest decline over 3 years	-44.63%	-18.76%	-25.87%
Max Drawdown (5Y) Largest decline over 5 years	-59.32%	-24.50%	-34.82%
Max Drawdown (10Y) Largest decline over 10 years	-70.71%	-33.72%	-36.99%
Current Drawdown Current decline from peak	-99.54%	-0.35%	-99.19%
Average Drawdown Average peak-to-trough decline	-86.27%	-9.03%	-77.24%
Ulcer Index Depth and duration of drawdowns from previous peaks	19.77%	2.03%	+17.74%

Volatility

XOMA vs. SPY - Volatility Comparison

The current volatility for XOMA Corporation (XOMA) is 3.73%, while State Street SPDR S&P 500 ETF (SPY) has a volatility of 4.52%. This indicates that XOMA experiences smaller price fluctuations and is considered to be less risky than SPY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XOMA	SPY	Difference
Volatility (1M) Calculated over the trailing 1-month period	3.73%	4.52%	-0.79%
Volatility (6M) Calculated over the trailing 6-month period	32.01%	9.98%	+22.03%
Volatility (1Y) Calculated over the trailing 1-year period	51.81%	12.55%	+39.26%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	60.22%	17.16%	+43.06%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	66.03%	17.92%	+48.11%

Dividends

XOMA vs. SPY - Dividend Comparison

XOMA has not paid dividends to shareholders, while SPY's dividend yield for the trailing twelve months is around 1.00%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
SPY State Street SPDR S&P 500 ETF	1.00%	1.07%	1.21%	1.40%	1.65%	1.20%	1.52%	1.75%	2.04%	1.80%	2.03%	2.06%
XOMA XOMA Corporation	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both XOMA and SPY in my portfolio?

XOMA and SPY have a correlation of 0.28, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, XOMA or SPY?

SPY has higher volatility (4.52%) compared to XOMA (3.73%). In terms of maximum drawdown, XOMA dropped -99.96% vs SPY's -55.19%.

Which has better risk-adjusted returns?

SPY currently has the higher Sharpe Ratio (1.76 vs 1.13), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.