TTOO vs. VTSAX

Last updated Jun 3, 2026

TTOO (T2 Biosystems, Inc.) is a stock, while VTSAX (Vanguard Total Stock Market Index Fund Admiral Shares) is Large Cap Blend Equities fund managed by Vanguard. Over the past 10 years, TTOO returned -81.65%/yr vs 15.09%/yr for VTSAX. At a 0.19 correlation, their price movements are largely independent.

Performance

TTOO vs. VTSAX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in T2 Biosystems, Inc. (TTOO) and Vanguard Total Stock Market Index Fund Admiral Shares (VTSAX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TTOO achieves a -60.00% return, which is significantly lower than VTSAX's 11.71% return. Over the past 10 years, TTOO has underperformed VTSAX with an annualized return of -81.65%, while VTSAX has yielded a comparatively higher 15.09% annualized return.

TTOO

• 1D: 0.00%
• 1M: -33.33%
• YTD: -60.00%
• 6M: -81.82%
• 1Y: -98.76%
• 3Y*: -94.19%
• 5Y*: -94.95%
• 10Y*: -81.65%

VTSAX

• 1D: 0.25%
• 1M: 5.10%
• YTD: 11.71%
• 6M: 12.07%
• 1Y: 29.65%
• 3Y*: 22.24%
• 5Y*: 12.88%
• 10Y*: 15.09%

*Multi-year figures are annualized to reflect compound growth (CAGR)

TTOO vs. VTSAX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
TTOO T2 Biosystems, Inc.	-60.00%	-98.81%	-93.31%	-95.58%	-94.50%	-58.37%	5.98%	-61.13%	-26.94%	-21.67%
VTSAX Vanguard Total Stock Market Index Fund Admiral Shares	11.71%	17.12%	23.23%	26.51%	-19.52%	25.72%	20.98%	30.79%	-5.18%	21.16%

Correlation

The correlation between TTOO and VTSAX is -0.12, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.12
Correlation (3Y) Calculated over the trailing 3-year period	0.02
Correlation (5Y) Calculated over the trailing 5-year period	0.13
Correlation (10Y) Calculated over the trailing 10-year period	0.18
Correlation (All Time) Calculated using the full available price history since Aug 8, 2014	0.19

The correlation between TTOO and VTSAX shifts across timeframes, from -0.12 (1 year) to 0.19 (all time), reflecting how their relationship changes across market environments.

Return for Risk

TTOO vs. VTSAX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TTOO

TTOO Risk / Return Rank: 51
TTOO Sharpe Ratio Rank: 38
TTOO Sortino Ratio Rank: 100
TTOO Omega Ratio Rank: 99
TTOO Calmar Ratio Rank: 1
TTOO Martin Ratio Rank: 16

VTSAX

VTSAX Risk / Return Rank: 72
VTSAX Sharpe Ratio Rank: 73
VTSAX Sortino Ratio Rank: 65
VTSAX Omega Ratio Rank: 64
VTSAX Calmar Ratio Rank: 74
VTSAX Martin Ratio Rank: 83

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TTOO vs. VTSAX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for T2 Biosystems, Inc. (TTOO) and Vanguard Total Stock Market Index Fund Admiral Shares (VTSAX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TTOO	VTSAX	Difference
Sharpe ratio Return per unit of total volatility	-0.06	2.49	-2.55
Sortino ratio Return per unit of downside risk	11.90	3.38	+8.52
Omega ratio Gain probability vs. loss probability	2.89	1.45	+1.44
Calmar ratio Return relative to maximum drawdown	-0.99	3.38	-4.37
Martin ratio Return relative to average drawdown	-1.11	15.63	-16.74
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TTOO vs. VTSAX - Sharpe Ratio Comparison

The current TTOO Sharpe Ratio is -0.06, which is lower than the VTSAX Sharpe Ratio of 2.49. The chart below compares the historical Sharpe Ratios of TTOO and VTSAX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	TTOO	VTSAX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.06	2.49	-2.55
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.13	0.75	-0.88
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.16	0.82	-0.98
Sharpe Ratio (All Time) Calculated using the full available price history	-0.16	0.47	-0.63

Drawdowns

TTOO vs. VTSAX - Drawdown Comparison

The maximum TTOO drawdown since its inception was -100.00%, which is greater than VTSAX's maximum drawdown of -55.33%. Use the drawdown chart below to compare losses from any high point for TTOO and VTSAX.

Drawdown Indicators

	TTOO	VTSAX	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-55.33%	-44.67%
Max Drawdown (1Y) Largest decline over 1 year	-99.88%	-8.92%	-90.96%
Max Drawdown (3Y) Largest decline over 3 years	-100.00%	-19.36%	-80.64%
Max Drawdown (5Y) Largest decline over 5 years	-100.00%	-25.36%	-74.64%
Max Drawdown (10Y) Largest decline over 10 years	-100.00%	-34.97%	-65.03%
Current Drawdown Current decline from peak	-100.00%	0.00%	-100.00%
Average Drawdown Average peak-to-trough decline	-83.65%	-9.01%	-74.64%
Ulcer Index Depth and duration of drawdowns from previous peaks	88.91%	1.93%	+86.98%

Volatility

TTOO vs. VTSAX - Volatility Comparison

T2 Biosystems, Inc. (TTOO) has a higher volatility of 401.24% compared to Vanguard Total Stock Market Index Fund Admiral Shares (VTSAX) at 2.95%. This indicates that TTOO's price experiences larger fluctuations and is considered to be riskier than VTSAX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TTOO	VTSAX	Difference
Volatility (1M) Calculated over the trailing 1-month period	401.24%	2.95%	+398.29%
Volatility (6M) Calculated over the trailing 6-month period	755.24%	9.20%	+746.04%
Volatility (1Y) Calculated over the trailing 1-year period	1,552.58%	12.21%	+1,540.37%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	719.38%	17.36%	+702.02%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	515.17%	18.41%	+496.76%

Dividends

TTOO vs. VTSAX - Dividend Comparison

TTOO has not paid dividends to shareholders, while VTSAX's dividend yield for the trailing twelve months is around 1.00%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
TTOO T2 Biosystems, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VTSAX Vanguard Total Stock Market Index Fund Admiral Shares	1.00%	1.11%	1.26%	1.42%	1.65%	1.20%	1.41%	1.76%	2.03%	1.71%	1.92%	1.98%

Frequently Asked Questions

Can I hold both TTOO and VTSAX in my portfolio?

TTOO and VTSAX have a correlation of -0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TTOO or VTSAX?

TTOO has higher volatility (401.24%) compared to VTSAX (2.95%). In terms of maximum drawdown, TTOO dropped -100.00% vs VTSAX's -55.33%.

Which has better risk-adjusted returns?

VTSAX currently has the higher Sharpe Ratio (2.48 vs -0.06), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.