SYRE vs. HSBH
SYRE (Spyre Therapeutics Inc.) is a stock, while HSBH (HSBC Holdings plc ADRhedged ETF) is Financials Equities fund tracking the HSBC Holdings plc Local Shares Total Return. Over the past year, SYRE returned 483.83% vs 78.08% for HSBH. Their 0.17 correlation means their historical movements had little consistent relationship.
Performance
SYRE vs. HSBH - Performance Comparison
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Returns By Period
In the year-to-date period, SYRE achieves a 189.77% return, which is significantly higher than HSBH's 40.22% return.
SYRE
- 1D
- -3.46%
- 1M
- 9.58%
- 6M
- 189.86%
- YTD
- 189.77%
- 1Y
- 483.83%
- 3Y*
- 99.24%
- 5Y*
- -10.47%
- 10Y*
- -2.09%
- ALL TIME*
- -8.95%
HSBH
- 1D
- 1.59%
- 1M
- 10.54%
- 6M
- 25.22%
- YTD
- 40.22%
- 1Y
- 78.08%
- 3Y*
- —
- 5Y*
- —
- 10Y*
- —
- ALL TIME*
- 69.44%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $1.79M | $1.37M | $645.59K | |
| $85.05M | $107.69M | $113.21M |
SYRE vs. HSBH - Yearly Performance Comparison
| 2026 (YTD) | 2025 | |
|---|---|---|
SYRE Spyre Therapeutics Inc. | 189.77% | 134.67% |
HSBH HSBC Holdings plc ADRhedged ETF | 40.22% | 39.95% |
Correlation
The correlation between SYRE and HSBH is 0.15, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.15 |
Correlation (All Time) Calculated using the full available price history since Apr 23, 2025 | 0.17 |
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Return for Risk
SYRE vs. HSBH — Risk / Return Rank
SYRE
HSBH
SYRE vs. HSBH - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Spyre Therapeutics Inc. (SYRE) and HSBC Holdings plc ADRhedged ETF (HSBH). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| SYRE | HSBH | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +3.72 | ||
| Sortino ratioReturn per unit of downside risk | +1.47 | ||
| Omega ratioGain probability vs. loss probability | 1.67 | 1.55 | +0.12 |
| Calmar ratioReturn relative to maximum drawdown | 32.91 | 5.30 | +27.61 |
| Martin ratioReturn relative to average drawdown | 84.95 | 19.48 | +65.47 |
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Drawdowns
SYRE vs. HSBH - Drawdown Comparison
The maximum SYRE drawdown since its inception was -99.11%, which is greater than HSBH's maximum drawdown of -14.81%. Use the drawdown chart below to compare losses from any high point for SYRE and HSBH.
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Drawdown Indicators
| SYRE | HSBH | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.11% | -14.81% | -84.30% |
Max Drawdown (1Y)Largest decline over 1 year | -14.83% | -14.81% | -0.02% |
Max Drawdown (3Y)Largest decline over 3 years | -73.99% | — | — |
Max Drawdown (5Y)Largest decline over 5 years | -98.74% | — | — |
Max Drawdown (10Y)Largest decline over 10 years | -99.04% | — | — |
Current DrawdownCurrent decline from peak | -68.33% | 0.00% | -68.33% |
Average DrawdownAverage peak-to-trough decline | -62.75% | -2.19% | -60.56% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 5.73% | 4.02% | +1.71% |
Volatility
SYRE vs. HSBH - Volatility Comparison
Spyre Therapeutics Inc. (SYRE) has a higher volatility of 18.14% compared to HSBC Holdings plc ADRhedged ETF (HSBH) at 6.50%. This indicates that SYRE's price experiences larger fluctuations and is considered to be riskier than HSBH based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| SYRE | HSBH | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 18.14% | 6.50% | +11.64% |
Volatility (6M)Calculated over the trailing 6-month period | 49.74% | 19.77% | +29.97% |
Volatility (1Y)Calculated over the trailing 1-year period | 69.59% | 23.81% | +45.78% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 179.36% | 22.72% | +156.64% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 136.18% | 22.72% | +113.46% |
Dividends
SYRE vs. HSBH - Dividend Comparison
SYRE has not paid dividends to shareholders, while HSBH's dividend yield for the trailing twelve months is around 2.12%.
| Position | TTM |
|---|---|
HSBH HSBC Holdings plc ADRhedged ETF | 2.12% |
SYRE Spyre Therapeutics Inc. | 0.00% |
Frequently Asked Questions
SYRE and HSBH have a correlation of 0.15, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
SYRE has higher volatility (18.14%) compared to HSBH (6.50%). In terms of maximum drawdown, SYRE dropped -99.11% vs HSBH's -14.81%.
SYRE currently has the higher Sharpe Ratio (7.03 vs 3.30), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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