SGMO vs. ACRS

Last updated Jun 3, 2026

SGMO (Sangamo Therapeutics, Inc.) and ACRS (Aclaris Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, SGMO returned -29.51%/yr vs -13.70%/yr for ACRS. At a 0.28 correlation, their price movements are largely independent.

Performance

SGMO vs. ACRS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Sangamo Therapeutics, Inc. (SGMO) and Aclaris Therapeutics, Inc. (ACRS). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, SGMO achieves a -49.05% return, which is significantly lower than ACRS's 53.82% return. Over the past 10 years, SGMO has underperformed ACRS with an annualized return of -29.51%, while ACRS has yielded a comparatively higher -13.70% annualized return.

SGMO

• 1D: 1.30%
• 1M: 58.52%
• YTD: -49.05%
• 6M: -51.39%
• 1Y: -54.75%
• 3Y*: -42.91%
• 5Y*: -54.33%
• 10Y*: -29.51%

ACRS

• 1D: 6.68%
• 1M: 4.99%
• YTD: 53.82%
• 6M: 71.48%
• 1Y: 221.53%
• 3Y*: -19.24%
• 5Y*: -26.71%
• 10Y*: -13.70%

*Multi-year figures are annualized to reflect compound growth (CAGR)

SGMO vs. ACRS - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
SGMO Sangamo Therapeutics, Inc.	-49.05%	-58.82%	87.74%	-82.70%	-58.13%	-51.94%	86.44%	-27.09%	-30.00%	437.70%
ACRS Aclaris Therapeutics, Inc.	53.82%	21.37%	136.19%	-93.33%	8.32%	124.73%	242.33%	-74.42%	-70.03%	-9.14%

Correlation

The correlation between SGMO and ACRS is 0.24, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.24
Correlation (3Y) Calculated over the trailing 3-year period	0.25
Correlation (5Y) Calculated over the trailing 5-year period	0.32
Correlation (10Y) Calculated over the trailing 10-year period	0.29
Correlation (All Time) Calculated using the full available price history since Oct 8, 2015	0.28

Fundamentals

Market Cap SGMO : $83.38M ACRS : $596.39M
EPS SGMO : -$0.38 ACRS : -$0.56
PS Ratio SGMO : 1.99 ACRS : 68.71
Total Revenue (TTM) SGMO : $34.56M ACRS : $8.37M
Gross Profit (TTM) SGMO : $25.51M ACRS : $6.39M
EBITDA (TTM) SGMO : -$106.29M ACRS : -$73.08M

Return for Risk

SGMO vs. ACRS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

SGMO

SGMO Risk / Return Rank: 22
SGMO Sharpe Ratio Rank: 22
SGMO Sortino Ratio Rank: 30
SGMO Omega Ratio Rank: 30
SGMO Calmar Ratio Rank: 18
SGMO Martin Ratio Rank: 11

ACRS

ACRS Risk / Return Rank: 91
ACRS Sharpe Ratio Rank: 90
ACRS Sortino Ratio Rank: 92
ACRS Omega Ratio Rank: 89
ACRS Calmar Ratio Rank: 93
ACRS Martin Ratio Rank: 93

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

SGMO vs. ACRS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Sangamo Therapeutics, Inc. (SGMO) and Aclaris Therapeutics, Inc. (ACRS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	SGMO	ACRS	Difference
Sharpe ratio Return per unit of total volatility	-0.44	2.30	-2.74
Sortino ratio Return per unit of downside risk	0.03	3.61	-3.58
Omega ratio Gain probability vs. loss probability	1.00	1.43	-0.43
Calmar ratio Return relative to maximum drawdown	-0.63	5.93	-6.55
Martin ratio Return relative to average drawdown	-1.29	16.31	-17.60
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

SGMO vs. ACRS - Sharpe Ratio Comparison

The current SGMO Sharpe Ratio is -0.44, which is lower than the ACRS Sharpe Ratio of 2.30. The chart below compares the historical Sharpe Ratios of SGMO and ACRS, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	SGMO	ACRS	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.44	2.30	-2.74
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.48	-0.29	-0.19
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.30	-0.12	-0.18
Sharpe Ratio (All Time) Calculated using the full available price history	-0.17	-0.07	-0.10

Drawdowns

SGMO vs. ACRS - Drawdown Comparison

The maximum SGMO drawdown since its inception was -99.80%, roughly equal to the maximum ACRS drawdown of -98.05%. Use the drawdown chart below to compare losses from any high point for SGMO and ACRS.

Drawdown Indicators

	SGMO	ACRS	Difference
Max Drawdown Largest peak-to-trough decline	-99.80%	-98.05%	-1.75%
Max Drawdown (1Y) Largest decline over 1 year	-86.32%	-36.64%	-49.68%
Max Drawdown (3Y) Largest decline over 3 years	-96.48%	-94.11%	-2.37%
Max Drawdown (5Y) Largest decline over 5 years	-99.17%	-97.12%	-2.05%
Max Drawdown (10Y) Largest decline over 10 years	-99.62%	-98.05%	-1.57%
Current Drawdown Current decline from peak	-99.57%	-85.97%	-13.60%
Average Drawdown Average peak-to-trough decline	-84.03%	-63.61%	-20.42%
Ulcer Index Depth and duration of drawdowns from previous peaks	41.76%	13.31%	+28.45%

Volatility

SGMO vs. ACRS - Volatility Comparison

Sangamo Therapeutics, Inc. (SGMO) has a higher volatility of 71.94% compared to Aclaris Therapeutics, Inc. (ACRS) at 14.60%. This indicates that SGMO's price experiences larger fluctuations and is considered to be riskier than ACRS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	SGMO	ACRS	Difference
Volatility (1M) Calculated over the trailing 1-month period	71.94%	14.60%	+57.34%
Volatility (6M) Calculated over the trailing 6-month period	116.53%	72.02%	+44.51%
Volatility (1Y) Calculated over the trailing 1-year period	125.76%	96.88%	+28.88%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	112.76%	92.60%	+20.16%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	98.51%	110.34%	-11.83%

Dividends

SGMO vs. ACRS - Dividend Comparison

Neither SGMO nor ACRS has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both SGMO and ACRS in my portfolio?

SGMO and ACRS have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, SGMO or ACRS?

SGMO has higher volatility (71.94%) compared to ACRS (14.60%). In terms of maximum drawdown, SGMO dropped -99.80% vs ACRS's -98.05%.

Which has better risk-adjusted returns?

ACRS currently has the higher Sharpe Ratio (2.30 vs -0.44), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.