RYOIX vs. FBTCX

Last updated Jun 24, 2026

RYOIX (Rydex Biotechnology Fund) and FBTCX (Fidelity Advisor Biotechnology Fund Class C) are both Health & Biotech Equities funds. Over the past 10 years, RYOIX returned 10.54%/yr vs 11.82%/yr for FBTCX. With a 0.96 correlation, they move nearly in lockstep. RYOIX charges 1.36%/yr vs 1.75%/yr for FBTCX.

Performance

RYOIX vs. FBTCX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Rydex Biotechnology Fund (RYOIX) and Fidelity Advisor Biotechnology Fund Class C (FBTCX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

The year-to-date returns for both investments are quite close, with RYOIX having a 11.45% return and FBTCX slightly higher at 11.67%. Over the past 10 years, RYOIX has underperformed FBTCX with an annualized return of 10.54%, while FBTCX has yielded a comparatively higher 11.82% annualized return.

RYOIX

• 1D: 2.06%
• 1M: 5.30%
• YTD: 11.45%
• 6M: 9.38%
• 1Y: 49.16%
• 3Y*: 15.68%
• 5Y*: 5.29%
• 10Y*: 10.54%

FBTCX

• 1D: 5.15%
• 1M: 8.09%
• YTD: 11.67%
• 6M: 9.05%
• 1Y: 63.57%
• 3Y*: 18.46%
• 5Y*: 8.45%
• 10Y*: 11.82%

*Multi-year figures are annualized to reflect compound growth (CAGR)

RYOIX vs. FBTCX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
RYOIX Rydex Biotechnology Fund	11.45%	30.62%	-0.95%	6.06%	-13.04%	2.05%	21.94%	30.69%	-8.94%	29.68%
FBTCX Fidelity Advisor Biotechnology Fund Class C	11.67%	38.48%	-2.00%	9.86%	-8.64%	-3.72%	31.17%	24.82%	-4.55%	24.81%

Correlation

The correlation between RYOIX and FBTCX is 0.88, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.88
Correlation (3Y) Calculated over the trailing 3-year period	0.89
Correlation (5Y) Calculated over the trailing 5-year period	0.90
Correlation (10Y) Calculated over the trailing 10-year period	0.93
Correlation (All Time) Calculated using the full available price history since Dec 27, 2000	0.96

The correlation between RYOIX and FBTCX has been stable across timeframes, ranging from 0.88 to 0.96 - a consistent structural relationship.

Return for Risk

RYOIX vs. FBTCX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

RYOIX

RYOIX Risk / Return Rank: 84
RYOIX Sharpe Ratio Rank: 82
RYOIX Sortino Ratio Rank: 80
RYOIX Omega Ratio Rank: 64
RYOIX Calmar Ratio Rank: 96
RYOIX Martin Ratio Rank: 96

FBTCX

FBTCX Risk / Return Rank: 87
FBTCX Sharpe Ratio Rank: 89
FBTCX Sortino Ratio Rank: 83
FBTCX Omega Ratio Rank: 72
FBTCX Calmar Ratio Rank: 97
FBTCX Martin Ratio Rank: 94

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

RYOIX vs. FBTCX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Rydex Biotechnology Fund (RYOIX) and Fidelity Advisor Biotechnology Fund Class C (FBTCX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	RYOIX	FBTCX	Difference
Sharpe ratio: Return per unit of total volatility	2.47	2.72	-0.24
Sortino ratio: Return per unit of downside risk	3.49	3.62	-0.13
Omega ratio: Gain probability vs. loss probability	1.41	1.43	-0.02
Calmar ratio: Return relative to maximum drawdown	5.80	6.97	-1.16
Martin ratio: Return relative to average drawdown	21.13	19.09	+2.04

RYOIX vs. FBTCX - Sharpe Ratio Comparison

The current RYOIX Sharpe Ratio is 2.47, which is comparable to the FBTCX Sharpe Ratio of 2.72. The chart below compares the historical Sharpe Ratios of RYOIX and FBTCX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

RYOIX vs. FBTCX - Drawdown Comparison

The maximum RYOIX drawdown since its inception was -74.43%, which is greater than FBTCX's maximum drawdown of -64.04%. Use the drawdown chart below to compare losses from any high point for RYOIX and FBTCX.

Drawdown Indicators

	RYOIX	FBTCX	Difference
Max Drawdown Largest peak-to-trough decline	-74.43%	-64.04%	-10.39%
Max Drawdown (1Y) Largest decline over 1 year	-8.43%	-9.04%	+0.61%
Max Drawdown (3Y) Largest decline over 3 years	-23.47%	-37.26%	+13.79%
Max Drawdown (5Y) Largest decline over 5 years	-33.66%	-37.26%	+3.60%
Max Drawdown (10Y) Largest decline over 10 years	-33.66%	-39.37%	+5.71%
Current Drawdown Current decline from peak	0.00%	0.00%	0.00%
Average Drawdown Average peak-to-trough decline	-27.59%	-23.04%	-4.55%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.31%	3.29%	-0.98%

Volatility

RYOIX vs. FBTCX - Volatility Comparison

The current volatility for Rydex Biotechnology Fund (RYOIX) is 6.63%, while Fidelity Advisor Biotechnology Fund Class C (FBTCX) has a volatility of 9.23%. This indicates that RYOIX experiences smaller price fluctuations and is considered to be less risky than FBTCX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	RYOIX	FBTCX	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.63%	9.23%	-2.60%
Volatility (6M) Calculated over the trailing 6-month period	15.35%	18.04%	-2.69%
Volatility (1Y) Calculated over the trailing 1-year period	19.83%	23.23%	-3.40%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	21.25%	23.84%	-2.59%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	23.23%	24.56%	-1.33%

RYOIX vs. FBTCX - Expense Ratio Comparison

RYOIX has a 1.36% expense ratio, which is lower than FBTCX's 1.75% expense ratio.

Dividends

RYOIX vs. FBTCX - Dividend Comparison

RYOIX's dividend yield for the trailing twelve months is around 11.28%, more than FBTCX's 1.51% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
FBTCX Fidelity Advisor Biotechnology Fund Class C	1.51%	1.68%	0.00%	0.00%	0.00%	24.50%	9.78%	7.92%	2.92%	0.00%	0.00%	5.73%
RYOIX Rydex Biotechnology Fund	11.28%	12.57%	14.61%	0.00%	1.29%	19.39%	7.28%	8.58%	14.11%	5.38%	0.00%	1.45%

Frequently Asked Questions

Can I hold both RYOIX and FBTCX in my portfolio?

RYOIX and FBTCX have a correlation of 0.88, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, RYOIX or FBTCX?

FBTCX has higher volatility (9.23%) compared to RYOIX (6.63%). In terms of maximum drawdown, RYOIX dropped -74.43% vs FBTCX's -64.04%.

Which has better risk-adjusted returns?

FBTCX currently has the higher Sharpe Ratio (2.72 vs 2.47), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.