QTUM vs. MEDX

Last updated Jun 12, 2026

QTUM (Defiance Quantum ETF) and MEDX (Horizon Kinetics Medical ETF) are both exchange-traded funds - QTUM is a Technology Equities fund tracking the BlueStar Machine Learning and Quantum Computing Index, while MEDX is a Health & Biotech Equities fund actively managed by Horizon. QTUM is passively managed, while MEDX is actively managed. Over the past 3 years, QTUM returned 48.21%/yr vs 6.59%/yr for MEDX. At a 0.32 correlation, their price movements are largely independent. QTUM charges 0.40%/yr vs 0.85%/yr for MEDX.

Performance

QTUM vs. MEDX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Defiance Quantum ETF (QTUM) and Horizon Kinetics Medical ETF (MEDX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, QTUM achieves a 45.62% return, which is significantly higher than MEDX's 4.62% return.

QTUM

• 1D: 5.54%
• 1M: 10.68%
• YTD: 45.62%
• 6M: 39.23%
• 1Y: 80.67%
• 3Y*: 48.21%
• 5Y*: 27.78%
• 10Y*: —

MEDX

• 1D: 1.69%
• 1M: 5.29%
• YTD: 4.62%
• 6M: 5.69%
• 1Y: 29.83%
• 3Y*: 6.59%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

QTUM vs. MEDX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
QTUM Defiance Quantum ETF	45.62%	36.65%	50.54%	26.54%
MEDX Horizon Kinetics Medical ETF	4.62%	28.62%	-4.68%	-5.77%

Correlation

The correlation between QTUM and MEDX is 0.24, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.24
Correlation (3Y) Calculated over the trailing 3-year period	0.33
Correlation (All Time) Calculated using the full available price history since Jan 31, 2023	0.32

QTUM vs. MEDX - Sectors Allocation Comparison

Sectors	QTUM	MEDX
Technology	85.1%	-
Industrials	8.7%	-
Communication Services	4.9%	-
Consumer Cyclical	0.7%	-
Healthcare	0.6%	100.0%
Basic Materials	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-
Real Estate	-	-
Utilities	-	-

Return for Risk

QTUM vs. MEDX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

QTUM

QTUM Risk / Return Rank: 91
QTUM Sharpe Ratio Rank: 93
QTUM Sortino Ratio Rank: 88
QTUM Omega Ratio Rank: 87
QTUM Calmar Ratio Rank: 92
QTUM Martin Ratio Rank: 92

MEDX

MEDX Risk / Return Rank: 59
MEDX Sharpe Ratio Rank: 57
MEDX Sortino Ratio Rank: 66
MEDX Omega Ratio Rank: 53
MEDX Calmar Ratio Rank: 66
MEDX Martin Ratio Rank: 54

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

QTUM vs. MEDX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Defiance Quantum ETF (QTUM) and Horizon Kinetics Medical ETF (MEDX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	QTUM	MEDX	Difference
Sharpe ratio: Return per unit of total volatility	2.86	1.65	+1.20
Sortino ratio: Return per unit of downside risk	3.38	2.59	+0.79
Omega ratio: Gain probability vs. loss probability	1.45	1.28	+0.17
Calmar ratio: Return relative to maximum drawdown	5.31	2.84	+2.47
Martin ratio: Return relative to average drawdown	19.26	7.85	+11.41

QTUM vs. MEDX - Sharpe Ratio Comparison

The current QTUM Sharpe Ratio is 2.86, which is higher than the MEDX Sharpe Ratio of 1.65. The chart below compares the historical Sharpe Ratios of QTUM and MEDX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

QTUM vs. MEDX - Drawdown Comparison

The maximum QTUM drawdown since its inception was -38.45%, which is greater than MEDX's maximum drawdown of -23.10%. Use the drawdown chart below to compare losses from any high point for QTUM and MEDX.

Drawdown Indicators

	QTUM	MEDX	Difference
Max Drawdown Largest peak-to-trough decline	-38.45%	-23.10%	-15.35%
Max Drawdown (1Y) Largest decline over 1 year	-15.26%	-10.54%	-4.72%
Max Drawdown (3Y) Largest decline over 3 years	-25.39%	-23.10%	-2.29%
Max Drawdown (5Y) Largest decline over 5 years	-38.45%	—	—
Current Drawdown Current decline from peak	-5.57%	-2.01%	-3.56%
Average Drawdown Average peak-to-trough decline	-8.25%	-6.69%	-1.56%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.20%	3.81%	+0.39%

Volatility

QTUM vs. MEDX - Volatility Comparison

Defiance Quantum ETF (QTUM) has a higher volatility of 14.24% compared to Horizon Kinetics Medical ETF (MEDX) at 5.57%. This indicates that QTUM's price experiences larger fluctuations and is considered to be riskier than MEDX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	QTUM	MEDX	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.24%	5.57%	+8.67%
Volatility (6M) Calculated over the trailing 6-month period	23.16%	13.38%	+9.78%
Volatility (1Y) Calculated over the trailing 1-year period	28.38%	18.13%	+10.25%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	27.00%	17.02%	+9.98%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	27.40%	17.02%	+10.38%

QTUM vs. MEDX - Expense Ratio Comparison

QTUM has a 0.40% expense ratio, which is lower than MEDX's 0.85% expense ratio.

Dividends

QTUM vs. MEDX - Dividend Comparison

QTUM's dividend yield for the trailing twelve months is around 0.74%, less than MEDX's 1.18% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018
MEDX Horizon Kinetics Medical ETF	1.18%	1.23%	1.92%	4.94%	0.00%	0.00%	0.00%	0.00%	0.00%
QTUM Defiance Quantum ETF	0.74%	1.01%	0.61%	0.81%	1.46%	0.48%	0.42%	0.61%	0.21%

Frequently Asked Questions

Can I hold both QTUM and MEDX in my portfolio?

QTUM and MEDX have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, QTUM or MEDX?

QTUM has higher volatility (14.24%) compared to MEDX (5.57%). In terms of maximum drawdown, QTUM dropped -38.45% vs MEDX's -23.10%.

Which ETF is better, QTUM or MEDX?

On 3-year performance, QTUM leads with 48.21% vs 6.59% for MEDX. On fees, QTUM is cheaper at 0.40% per year. On volatility, MEDX has been the lower-risk option at 5.57%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, QTUM or MEDX?

Over the 3-year period, QTUM has performed better with a 48.21% return vs 6.59%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, QTUM or MEDX?

QTUM is cheaper with a 0.40% expense ratio, compared with 0.85% for MEDX.

Which ETF pays a higher dividend yield, QTUM or MEDX?

MEDX has the higher dividend yield at 1.18%, compared with 0.74% for QTUM.

What is the main difference between QTUM and MEDX?

QTUM is categorized as Technology Equities, while MEDX is Health & Biotech Equities. They also come from different issuers: Defiance and Horizon. Their fees differ too: 0.40% for QTUM and 0.85% for MEDX.

Which has better risk-adjusted returns?

QTUM currently has the higher Sharpe Ratio (2.86 vs 1.65), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.