QTTB vs. VXUS

Last updated Jul 25, 2026

QTTB (Q32 Bio Inc) is a stock, while VXUS (Vanguard Total International Stock ETF) is Global Equities fund tracking the FTSE Global All Cap ex US Index. Over the past 5 years, QTTB returned -33.56%/yr vs 8.43%/yr for VXUS. At a 0.23 correlation, their price movements are largely independent.

Performance

QTTB vs. VXUS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Q32 Bio Inc (QTTB) and Vanguard Total International Stock ETF (VXUS). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, QTTB achieves a 356.33% return, which is significantly higher than VXUS's 11.16% return.

QTTB

• 1D: -1.50%
• 1M: 26.78%
• 6M: 285.50%
• YTD: 356.33%
• 1Y: 585.52%
• 3Y*: -6.51%
• 5Y*: -33.56%
• 10Y*: —
• ALL TIME*: -32.80%

VXUS

• 1D: -0.26%
• 1M: -1.97%
• 6M: 5.45%
• YTD: 11.16%
• 1Y: 21.77%
• 3Y*: 16.57%
• 5Y*: 8.43%
• 10Y*: 9.35%
• ALL TIME*: 6.46%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
QTTB Q32 Bio Inc	$87.38M	$45.74M	$22.72M
VXUS Vanguard Total International Stock ETF	$386.57M	$447.19M	$513.76M

QTTB vs. VXUS - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
QTTB Q32 Bio Inc	356.33%	-3.49%	-68.57%	-51.75%	-65.38%	-67.76%	-45.46%	-7.42%	-2.78%
VXUS Vanguard Total International Stock ETF	11.16%	32.35%	5.08%	15.86%	-16.08%	8.98%	10.66%	21.75%	-12.99%

Correlation

The correlation between QTTB and VXUS is 0.03, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.03
Correlation (3Y) Calculated over the trailing 3-year period	0.10
Correlation (5Y) Calculated over the trailing 5-year period	0.19
Correlation (All Time) Calculated using the full available price history since Mar 28, 2018	0.23

Over the past year, the correlation between QTTB and VXUS has dropped to 0.03 - well below their long-term average of 0.23, suggesting their price drivers have been diverging.

Return for Risk

QTTB vs. VXUS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

QTTB

QTTB Risk / Return Rank: 98
QTTB Sharpe Ratio Rank: 98
QTTB Sortino Ratio Rank: 98
QTTB Omega Ratio Rank: 96
QTTB Calmar Ratio Rank: 99
QTTB Martin Ratio Rank: 99

VXUS

VXUS Risk / Return Rank: 56
VXUS Sharpe Ratio Rank: 55
VXUS Sortino Ratio Rank: 53
VXUS Omega Ratio Rank: 55
VXUS Calmar Ratio Rank: 55
VXUS Martin Ratio Rank: 60

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

QTTB vs. VXUS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Q32 Bio Inc (QTTB) and Vanguard Total International Stock ETF (VXUS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	QTTB	VXUS	Difference
Sharpe ratio: Return per unit of total volatility	3.21	1.30	+1.91
Sortino ratio: Return per unit of downside risk	4.40	1.84	+2.56
Omega ratio: Gain probability vs. loss probability	1.52	1.24	+0.27
Calmar ratio: Return relative to maximum drawdown	10.97	1.92	+9.04
Martin ratio: Return relative to average drawdown	28.17	7.12	+21.05

QTTB vs. VXUS - Sharpe Ratio Comparison

The current QTTB Sharpe Ratio is 3.21, which is higher than the VXUS Sharpe Ratio of 1.30. The chart below compares the historical Sharpe Ratios of QTTB and VXUS, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

QTTB vs. VXUS - Drawdown Comparison

The maximum QTTB drawdown since its inception was -99.75%, which is greater than VXUS's maximum drawdown of -35.97%. Use the drawdown chart below to compare losses from any high point for QTTB and VXUS.

Drawdown Indicators

	QTTB	VXUS	Difference
Max Drawdown Largest peak-to-trough decline	-99.75%	-35.97%	-63.78%
Max Drawdown (1Y) Largest decline over 1 year	-51.14%	-11.27%	-39.87%
Max Drawdown (3Y) Largest decline over 3 years	-97.31%	-13.58%	-83.73%
Max Drawdown (5Y) Largest decline over 5 years	-99.13%	-29.44%	-69.69%
Max Drawdown (10Y) Largest decline over 10 years	—	-35.97%	—
Current Drawdown Current decline from peak	-97.23%	-4.20%	-93.03%
Average Drawdown Average peak-to-trough decline	-73.26%	-8.17%	-65.09%
Ulcer Index Depth and duration of drawdowns from previous peaks	20.35%	3.04%	+17.31%

Volatility

QTTB vs. VXUS - Volatility Comparison

Q32 Bio Inc (QTTB) has a higher volatility of 74.27% compared to Vanguard Total International Stock ETF (VXUS) at 4.58%. This indicates that QTTB's price experiences larger fluctuations and is considered to be riskier than VXUS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	QTTB	VXUS	Difference
Volatility (1M) Calculated over the trailing 1-month period	74.27%	4.58%	+69.69%
Volatility (6M) Calculated over the trailing 6-month period	118.94%	14.83%	+104.11%
Volatility (1Y) Calculated over the trailing 1-year period	174.83%	16.66%	+158.17%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	131.03%	16.31%	+114.72%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	110.36%	17.00%	+93.36%

Dividends

QTTB vs. VXUS - Dividend Comparison

QTTB has not paid dividends to shareholders, while VXUS's dividend yield for the trailing twelve months is around 2.62%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
QTTB Q32 Bio Inc	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VXUS Vanguard Total International Stock ETF	2.62%	3.18%	3.37%	3.24%	3.09%	3.10%	2.14%	3.06%	3.18%	2.73%	2.93%	2.83%

Frequently Asked Questions

Can I hold both QTTB and VXUS in my portfolio?

QTTB and VXUS have a correlation of 0.03, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, QTTB or VXUS?

QTTB has higher volatility (74.27%) compared to VXUS (4.58%). In terms of maximum drawdown, QTTB dropped -99.75% vs VXUS's -35.97%.

Which has better risk-adjusted returns?

QTTB currently has the higher Sharpe Ratio (3.21 vs 1.30), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.