PVLA vs. NTRA

Last updated Aug 1, 2026

PVLA (Palvella Therapeutics, Inc) and NTRA (Natera, Inc.) are both stocks. Both are in the Healthcare sector — PVLA in Biotechnology, NTRA in Diagnostics & Research. Over the past year, PVLA returned 280.41% vs 98.96% for NTRA. Their 0.19 correlation means their historical movements had little consistent relationship.

Performance

PVLA vs. NTRA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Palvella Therapeutics, Inc (PVLA) and Natera, Inc. (NTRA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PVLA achieves a 32.84% return, which is significantly higher than NTRA's 16.88% return.

PVLA

• 1D: -7.42%
• 1M: -5.26%
• 6M: 81.30%
• YTD: 32.84%
• 1Y: 280.41%
• 3Y*: —
• 5Y*: —
• 10Y*: —
• ALL TIME*: 329.85%

NTRA

• 1D: -0.70%
• 1M: -4.14%
• 6M: 15.84%
• YTD: 16.88%
• 1Y: 98.96%
• 3Y*: 80.73%
• 5Y*: 18.51%
• 10Y*: 35.27%
• ALL TIME*: 25.25%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
NTRA Natera, Inc.	$246.10M	$302.11M	$352.98M
PVLA Palvella Therapeutics, Inc	$30.14M	$31.68M	$34.01M

PVLA vs. NTRA - Yearly Performance Comparison

	2026 (YTD)	2025	2024
PVLA Palvella Therapeutics, Inc	32.84%	772.25%	-8.27%
NTRA Natera, Inc.	16.88%	44.72%	-4.95%

Correlation

The correlation between PVLA and NTRA is 0.29, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.29
Correlation (All Time) Calculated using the full available price history since Dec 16, 2024	0.19

The correlation between PVLA and NTRA shifts across timeframes, from 0.19 (all time) to 0.29 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap PVLA : $1.99B NTRA : $38.35B
EPS PVLA : -$3.74 NTRA : -$1.63
PB Ratio PVLA : 55.90 NTRA : 21.36
Total Revenue (TTM) PVLA : $0.00 NTRA : $2.50B
Gross Profit (TTM) PVLA : $0.00 NTRA : $1.63B
EBITDA (TTM) PVLA : -$14.75M NTRA : -$294.86M

Return for Risk

PVLA vs. NTRA — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

PVLA

PVLA Risk / Return Rank: 96
PVLA Sharpe Ratio Rank: 98
PVLA Sortino Ratio Rank: 95
PVLA Omega Ratio Rank: 93
PVLA Calmar Ratio Rank: 98
PVLA Martin Ratio Rank: 98

NTRA

NTRA Risk / Return Rank: 90
NTRA Sharpe Ratio Rank: 94
NTRA Sortino Ratio Rank: 90
NTRA Omega Ratio Rank: 90
NTRA Calmar Ratio Rank: 90
NTRA Martin Ratio Rank: 87

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

PVLA vs. NTRA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Palvella Therapeutics, Inc (PVLA) and Natera, Inc. (NTRA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	PVLA	NTRA	Difference
Sharpe ratio: Return per unit of total volatility	3.33	2.30	+1.03
Sortino ratio: Return per unit of downside risk	3.36	2.75	+0.61
Omega ratio: Gain probability vs. loss probability	1.42	1.36	+0.06
Calmar ratio: Return relative to maximum drawdown	9.07	3.58	+5.49
Martin ratio: Return relative to average drawdown	20.11	8.06	+12.05

PVLA vs. NTRA - Sharpe Ratio Comparison

The current PVLA Sharpe Ratio is 3.33, which is higher than the NTRA Sharpe Ratio of 2.30. The chart below compares the historical Sharpe Ratios of PVLA and NTRA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

PVLA vs. NTRA - Drawdown Comparison

The maximum PVLA drawdown since its inception was -31.48%, smaller than the maximum NTRA drawdown of -77.74%. Use the drawdown chart below to compare losses from any high point for PVLA and NTRA.

Drawdown Indicators

	PVLA	NTRA	Difference
Max Drawdown Largest peak-to-trough decline	-31.48%	-77.74%	+46.26%
Max Drawdown (1Y) Largest decline over 1 year	-31.11%	-28.20%	-2.91%
Max Drawdown (3Y) Largest decline over 3 years	—	-39.94%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-77.74%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-77.74%	—
Current Drawdown Current decline from peak	-11.57%	-5.65%	-5.92%
Average Drawdown Average peak-to-trough decline	-10.88%	-33.10%	+22.22%
Ulcer Index Depth and duration of drawdowns from previous peaks	14.00%	12.50%	+1.50%

Volatility

PVLA vs. NTRA - Volatility Comparison

Palvella Therapeutics, Inc (PVLA) has a higher volatility of 33.15% compared to Natera, Inc. (NTRA) at 10.71%. This indicates that PVLA's price experiences larger fluctuations and is considered to be riskier than NTRA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PVLA	NTRA	Difference
Volatility (1M) Calculated over the trailing 1-month period	33.15%	10.71%	+22.44%
Volatility (6M) Calculated over the trailing 6-month period	65.81%	36.89%	+28.92%
Volatility (1Y) Calculated over the trailing 1-year period	84.76%	44.12%	+40.64%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	84.09%	57.04%	+27.05%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	84.09%	60.84%	+23.25%

Dividends

PVLA vs. NTRA - Dividend Comparison

Neither PVLA nor NTRA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both PVLA and NTRA in my portfolio?

PVLA and NTRA have a correlation of 0.29, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PVLA or NTRA?

PVLA has higher volatility (33.15%) compared to NTRA (10.71%). In terms of maximum drawdown, PVLA dropped -31.48% vs NTRA's -77.74%.

Which has better risk-adjusted returns?

PVLA currently has the higher Sharpe Ratio (3.33 vs 2.30), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.