PTCT vs. HCA

Last updated Jun 4, 2026

PTCT (PTC Therapeutics, Inc.) and HCA (HCA Healthcare, Inc.) are both stocks. Both are in the Healthcare sector — PTCT in Biotechnology, HCA in Medical Care Facilities. Over the past 10 years, PTCT returned 24.54%/yr vs 17.50%/yr for HCA. At a 0.22 correlation, their price movements are largely independent.

Performance

PTCT vs. HCA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in PTC Therapeutics, Inc. (PTCT) and HCA Healthcare, Inc. (HCA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PTCT achieves a -9.58% return, which is significantly higher than HCA's -22.08% return. Over the past 10 years, PTCT has outperformed HCA with an annualized return of 24.54%, while HCA has yielded a comparatively lower 17.50% annualized return.

PTCT

• 1D: 0.66%
• 1M: 4.87%
• YTD: -9.58%
• 6M: -9.35%
• 1Y: 35.49%
• 3Y*: 15.90%
• 5Y*: 11.88%
• 10Y*: 24.54%

HCA

• 1D: -1.12%
• 1M: -14.97%
• YTD: -22.08%
• 6M: -25.16%
• 1Y: -4.54%
• 3Y*: 10.68%
• 5Y*: 12.13%
• 10Y*: 17.50%

*Multi-year figures are annualized to reflect compound growth (CAGR)

PTCT vs. HCA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PTCT PTC Therapeutics, Inc.	-9.58%	68.28%	63.79%	-27.80%	-4.17%	-34.74%	27.07%	39.95%	105.76%	52.89%
HCA HCA Healthcare, Inc.	-22.08%	56.71%	11.75%	13.83%	-5.64%	57.58%	12.07%	20.24%	43.37%	18.67%

Correlation

The correlation between PTCT and HCA is 0.09, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.09
Correlation (3Y) Calculated over the trailing 3-year period	0.14
Correlation (5Y) Calculated over the trailing 5-year period	0.17
Correlation (10Y) Calculated over the trailing 10-year period	0.21
Correlation (All Time) Calculated using the full available price history since Jun 21, 2013	0.22

The correlation between PTCT and HCA shifts across timeframes, from 0.09 (1 year) to 0.22 (all time), reflecting how their relationship changes across market environments.

Fundamentals

EPS PTCT : -$2.27 HCA : $28.46
PS Ratio PTCT : 6.82 HCA : 1.15
Total Revenue (TTM) PTCT : $827.11M HCA : $75.60B
Gross Profit (TTM) PTCT : $410.90M HCA : $31.37B
EBITDA (TTM) PTCT : -$38.52M HCA : $15.60B

Return for Risk

PTCT vs. HCA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PTCT

PTCT Risk / Return Rank: 66
PTCT Sharpe Ratio Rank: 69
PTCT Sortino Ratio Rank: 65
PTCT Omega Ratio Rank: 64
PTCT Calmar Ratio Rank: 67
PTCT Martin Ratio Rank: 65

HCA

HCA Risk / Return Rank: 32
HCA Sharpe Ratio Rank: 33
HCA Sortino Ratio Rank: 28
HCA Omega Ratio Rank: 28
HCA Calmar Ratio Rank: 36
HCA Martin Ratio Rank: 32

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PTCT vs. HCA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for PTC Therapeutics, Inc. (PTCT) and HCA Healthcare, Inc. (HCA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PTCT	HCA	Difference
Sharpe ratio Return per unit of total volatility	0.86	-0.17	+1.03
Sortino ratio Return per unit of downside risk	1.49	-0.05	+1.54
Omega ratio Gain probability vs. loss probability	1.19	0.99	+0.19
Calmar ratio Return relative to maximum drawdown	1.31	-0.14	+1.45
Martin ratio Return relative to average drawdown	2.72	-0.46	+3.18
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PTCT vs. HCA - Sharpe Ratio Comparison

The current PTCT Sharpe Ratio is 0.86, which is higher than the HCA Sharpe Ratio of -0.17. The chart below compares the historical Sharpe Ratios of PTCT and HCA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	PTCT	HCA	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.86	-0.17	+1.03
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.22	0.41	-0.19
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.37	0.54	-0.17
Sharpe Ratio (All Time) Calculated using the full available price history	0.16	0.60	-0.44

Drawdowns

PTCT vs. HCA - Drawdown Comparison

The maximum PTCT drawdown since its inception was -94.60%, which is greater than HCA's maximum drawdown of -54.74%. Use the drawdown chart below to compare losses from any high point for PTCT and HCA.

Drawdown Indicators

	PTCT	HCA	Difference
Max Drawdown Largest peak-to-trough decline	-94.60%	-54.74%	-39.86%
Max Drawdown (1Y) Largest decline over 1 year	-27.17%	-33.27%	+6.10%
Max Drawdown (3Y) Largest decline over 3 years	-59.86%	-33.27%	-26.59%
Max Drawdown (5Y) Largest decline over 5 years	-69.42%	-39.49%	-29.93%
Max Drawdown (10Y) Largest decline over 10 years	-73.78%	-54.74%	-19.04%
Current Drawdown Current decline from peak	-20.37%	-33.27%	+12.90%
Average Drawdown Average peak-to-trough decline	-46.09%	-11.01%	-35.08%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.09%	9.85%	+3.24%

Volatility

PTCT vs. HCA - Volatility Comparison

PTC Therapeutics, Inc. (PTCT) has a higher volatility of 18.71% compared to HCA Healthcare, Inc. (HCA) at 6.36%. This indicates that PTCT's price experiences larger fluctuations and is considered to be riskier than HCA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PTCT	HCA	Difference
Volatility (1M) Calculated over the trailing 1-month period	18.71%	6.36%	+12.35%
Volatility (6M) Calculated over the trailing 6-month period	29.23%	21.12%	+8.11%
Volatility (1Y) Calculated over the trailing 1-year period	41.80%	26.90%	+14.90%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	54.86%	29.80%	+25.06%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	66.56%	32.60%	+33.96%

Dividends

PTCT vs. HCA - Dividend Comparison

PTCT has not paid dividends to shareholders, while HCA's dividend yield for the trailing twelve months is around 0.81%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018
HCA HCA Healthcare, Inc.	0.81%	0.62%	0.88%	0.89%	0.93%	0.75%	0.63%	1.08%	1.12%
PTCT PTC Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Financials

PTCT vs. HCA - Profitability Comparison

The chart below illustrates the profitability comparison between PTC Therapeutics, Inc. and HCA Healthcare, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

PTCT - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, PTC Therapeutics, Inc. reported a gross profit of 0.00 and revenue of 272.55M. Therefore, the gross margin over that period was 0.0%.

HCA - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, HCA Healthcare, Inc. reported a gross profit of 8.18B and revenue of 19.51B. Therefore, the gross margin over that period was 41.9%.

PTCT - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, PTC Therapeutics, Inc. reported an operating income of 44.96M and revenue of 272.55M, resulting in an operating margin of 16.5%.

HCA - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, HCA Healthcare, Inc. reported an operating income of 3.18B and revenue of 19.51B, resulting in an operating margin of 16.3%.

PTCT - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, PTC Therapeutics, Inc. reported a net income of -2.81M and revenue of 272.55M, resulting in a net margin of -1.0%.

HCA - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, HCA Healthcare, Inc. reported a net income of 1.88B and revenue of 19.51B, resulting in a net margin of 9.6%.

Frequently Asked Questions

Can I hold both PTCT and HCA in my portfolio?

PTCT and HCA have a correlation of 0.09, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PTCT or HCA?

PTCT has higher volatility (18.71%) compared to HCA (6.36%). In terms of maximum drawdown, PTCT dropped -94.60% vs HCA's -54.74%.

Which has better risk-adjusted returns?

PTCT currently has the higher Sharpe Ratio (0.86 vs -0.17), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.