PMVP vs. PRLD

Last updated Aug 4, 2026

PMVP (PMV Pharmaceuticals, Inc.) and PRLD (Prelude Therapeutics Incorporated) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, PMVP returned -50.16%/yr vs -32.60%/yr for PRLD. Their 0.23 correlation means their historical movements had little consistent relationship.

Performance

PMVP vs. PRLD - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in PMV Pharmaceuticals, Inc. (PMVP) and Prelude Therapeutics Incorporated (PRLD). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PMVP achieves a -10.40% return, which is significantly lower than PRLD's 51.38% return.

PMVP

• 1D: 0.90%
• 1M: -8.20%
• 6M: 5.66%
• YTD: -10.40%
• 1Y: -20.00%
• 3Y*: -44.64%
• 5Y*: -50.16%
• 10Y*: —
• ALL TIME*: -44.46%

PRLD

• 1D: -4.57%
• 1M: -10.59%
• 6M: 116.26%
• YTD: 51.38%
• 1Y: 430.00%
• 3Y*: 6.15%
• 5Y*: -32.60%
• 10Y*: —
• ALL TIME*: -25.83%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
PMVP PMV Pharmaceuticals, Inc.	$494.13K	$487.49K	$457.02K
PRLD Prelude Therapeutics Incorporated	$1.90M	$1.67M	$1.93M

PMVP vs. PRLD - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
PMVP PMV Pharmaceuticals, Inc.	-10.40%	-17.22%	-51.29%	-64.37%	-62.34%	-62.45%	75.74%
PRLD Prelude Therapeutics Incorporated	51.38%	127.45%	-70.14%	-29.30%	-51.49%	-82.60%	183.59%

Correlation

The correlation between PMVP and PRLD is 0.23, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.23
Correlation (3Y) Balances recent behavior with more history.	0.20
Correlation (5Y) Shows whether the relationship held over a longer period.	0.24
Correlation (All Time) Calculated using the full available price history since Sep 25, 2020	0.23

Fundamentals

Market Cap PMVP : $59.73M PRLD : $249.93M
EPS PMVP : -$1.47 PRLD : -$1.05
PB Ratio PMVP : 0.68 PRLD : 6.02
Total Revenue (TTM) PMVP : $0.00 PRLD : $16.72M
Gross Profit (TTM) PMVP : -$97.00K PRLD : $11.30M
EBITDA (TTM) PMVP : -$80.43M PRLD : -$82.17M

Return for Risk

PMVP vs. PRLD — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

PMVP

PMVP Risk / Return Rank: 29
PMVP Sharpe Ratio Rank: 31
PMVP Sortino Ratio Rank: 33
PMVP Omega Ratio Rank: 33
PMVP Calmar Ratio Rank: 25
PMVP Martin Ratio Rank: 26

PRLD

PRLD Risk / Return Rank: 95
PRLD Sharpe Ratio Rank: 93
PRLD Sortino Ratio Rank: 95
PRLD Omega Ratio Rank: 96
PRLD Calmar Ratio Rank: 97
PRLD Martin Ratio Rank: 95

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

PMVP vs. PRLD - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for PMV Pharmaceuticals, Inc. (PMVP) and Prelude Therapeutics Incorporated (PRLD). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	PMVP	PRLD	Difference
Sharpe ratio: Return per unit of total volatility	-0.28	2.17	-2.45
Sortino ratio: Return per unit of downside risk	0.05	3.60	-3.54
Omega ratio: Gain probability vs. loss probability	1.01	1.51	-0.50
Calmar ratio: Return relative to maximum drawdown	-0.48	6.18	-6.67
Martin ratio: Return relative to average drawdown	-0.84	13.70	-14.54

PMVP vs. PRLD - Sharpe Ratio Comparison

The current PMVP Sharpe Ratio is -0.28, which is lower than the PRLD Sharpe Ratio of 2.17. The chart below compares the historical Sharpe Ratios of PMVP and PRLD, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

PMVP vs. PRLD - Drawdown Comparison

The maximum PMVP drawdown since its inception was -98.64%, roughly equal to the maximum PRLD drawdown of -99.33%. Use the drawdown chart below to compare losses from any high point for PMVP and PRLD.

Drawdown Indicators

	PMVP	PRLD	Difference
Max Drawdown Largest peak-to-trough decline	-98.64%	-99.33%	+0.69%
Max Drawdown (1Y) Largest decline over 1 year	-41.67%	-70.10%	+28.43%
Max Drawdown (3Y) Largest decline over 3 years	-90.61%	-90.42%	-0.19%
Max Drawdown (5Y) Largest decline over 5 years	-97.71%	-98.42%	+0.71%
Current Drawdown Current decline from peak	-98.18%	-95.21%	-2.97%
Average Drawdown Average peak-to-trough decline	-80.21%	-85.39%	+5.18%
Ulcer Index Depth and duration of drawdowns from previous peaks	23.89%	31.57%	-7.68%

Volatility

PMVP vs. PRLD - Volatility Comparison

The current volatility for PMV Pharmaceuticals, Inc. (PMVP) is 20.09%, while Prelude Therapeutics Incorporated (PRLD) has a volatility of 25.84%. This indicates that PMVP experiences smaller price fluctuations and is considered to be less risky than PRLD based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PMVP	PRLD	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.09%	25.84%	-5.75%
Volatility (6M) Calculated over the trailing 6-month period	51.64%	78.30%	-26.66%
Volatility (1Y) Calculated over the trailing 1-year period	71.30%	200.19%	-128.89%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	76.94%	125.66%	-48.72%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	76.86%	121.39%	-44.53%

Dividends

PMVP vs. PRLD - Dividend Comparison

Neither PMVP nor PRLD has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both PMVP and PRLD in my portfolio?

PMVP and PRLD have a correlation of 0.23, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PMVP or PRLD?

PRLD has higher volatility (25.84%) compared to PMVP (20.09%). In terms of maximum drawdown, PMVP dropped -98.64% vs PRLD's -99.33%.

Which has better risk-adjusted returns?

PRLD currently has the higher Sharpe Ratio (2.17 vs -0.28), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.