NVNO vs. ACXP

Last updated Jun 23, 2026

NVNO (enVVeno Medical Corporation) and ACXP (Acurx Pharmaceuticals, Inc.) are both stocks. Both are in the Healthcare sector — NVNO in Medical Devices, ACXP in Biotechnology. Over the past 3 years, NVNO returned -51.62%/yr vs -69.14%/yr for ACXP. At a 0.15 correlation, their price movements are largely independent.

Performance

NVNO vs. ACXP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in enVVeno Medical Corporation (NVNO) and Acurx Pharmaceuticals, Inc. (ACXP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, NVNO achieves a -6.48% return, which is significantly higher than ACXP's -39.36% return.

NVNO

• 1D: 5.00%
• 1M: -4.20%
• YTD: -6.48%
• 6M: -7.72%
• 1Y: -92.59%
• 3Y*: -51.62%
• 5Y*: -45.55%
• 10Y*: —

ACXP

• 1D: -1.95%
• 1M: -23.35%
• YTD: -39.36%
• 6M: -56.23%
• 1Y: -86.27%
• 3Y*: -69.14%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

NVNO vs. ACXP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
NVNO enVVeno Medical Corporation	-6.48%	-89.38%	-41.25%	0.78%	-22.61%	1.23%
ACXP Acurx Pharmaceuticals, Inc.	-39.36%	-84.71%	-78.75%	-3.77%	-7.90%	-27.37%

Correlation

The correlation between NVNO and ACXP is 0.26, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.26
Correlation (3Y) Calculated over the trailing 3-year period	0.20
Correlation (All Time) Calculated using the full available price history since Jun 25, 2021	0.15

The correlation between NVNO and ACXP shifts across timeframes, from 0.15 (all time) to 0.26 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap NVNO : $6.87M ACXP : $4.10M
EPS NVNO : -$58.99 ACXP : -$959.29
PB Ratio NVNO : 0.29 ACXP : 0.00
Total Revenue (TTM) NVNO : $0.00 ACXP : $0.00
Gross Profit (TTM) NVNO : -$491.00K ACXP : $0.00
EBITDA (TTM) NVNO : -$18.82M ACXP : -$5.88M

Return for Risk

NVNO vs. ACXP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

NVNO

NVNO Risk / Return Rank: 8
NVNO Sharpe Ratio Rank: 10
NVNO Sortino Ratio Rank: 5
NVNO Omega Ratio Rank: 3
NVNO Calmar Ratio Rank: 3
NVNO Martin Ratio Rank: 18

ACXP

ACXP Risk / Return Rank: 14
ACXP Sharpe Ratio Rank: 22
ACXP Sortino Ratio Rank: 15
ACXP Omega Ratio Rank: 17
ACXP Calmar Ratio Rank: 3
ACXP Martin Ratio Rank: 13

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

NVNO vs. ACXP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for enVVeno Medical Corporation (NVNO) and Acurx Pharmaceuticals, Inc. (ACXP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	NVNO	ACXP	Difference
Sharpe ratio: Return per unit of total volatility	-0.78	-0.46	-0.33
Sortino ratio: Return per unit of downside risk	-1.57	-0.83	-0.74
Omega ratio: Gain probability vs. loss probability	0.74	0.91	-0.17
Calmar ratio: Return relative to maximum drawdown	-0.97	-0.97	0.00
Martin ratio: Return relative to average drawdown	-1.11	-1.25	+0.14

NVNO vs. ACXP - Sharpe Ratio Comparison

The current NVNO Sharpe Ratio is -0.78, which is lower than the ACXP Sharpe Ratio of -0.46. The chart below compares the historical Sharpe Ratios of NVNO and ACXP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

NVNO vs. ACXP - Drawdown Comparison

The maximum NVNO drawdown since its inception was -99.81%, roughly equal to the maximum ACXP drawdown of -99.14%. Use the drawdown chart below to compare losses from any high point for NVNO and ACXP.

Drawdown Indicators

	NVNO	ACXP	Difference
Max Drawdown Largest peak-to-trough decline	-99.81%	-99.14%	-0.67%
Max Drawdown (1Y) Largest decline over 1 year	-95.28%	-89.26%	-6.02%
Max Drawdown (3Y) Largest decline over 3 years	-96.27%	-98.83%	+2.56%
Max Drawdown (5Y) Largest decline over 5 years	-97.66%	—	—
Current Drawdown Current decline from peak	-99.77%	-99.04%	-0.73%
Average Drawdown Average peak-to-trough decline	-89.98%	-69.51%	-20.47%
Ulcer Index Depth and duration of drawdowns from previous peaks	83.37%	69.15%	+14.22%

Volatility

NVNO vs. ACXP - Volatility Comparison

enVVeno Medical Corporation (NVNO) has a higher volatility of 12.87% compared to Acurx Pharmaceuticals, Inc. (ACXP) at 12.17%. This indicates that NVNO's price experiences larger fluctuations and is considered to be riskier than ACXP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	NVNO	ACXP	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.87%	12.17%	+0.70%
Volatility (6M) Calculated over the trailing 6-month period	60.29%	119.74%	-59.45%
Volatility (1Y) Calculated over the trailing 1-year period	118.30%	188.57%	-70.27%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	81.46%	140.92%	-59.46%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	93.51%	140.92%	-47.41%

Dividends

NVNO vs. ACXP - Dividend Comparison

Neither NVNO nor ACXP has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both NVNO and ACXP in my portfolio?

NVNO and ACXP have a correlation of 0.26, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, NVNO or ACXP?

NVNO has higher volatility (12.87%) compared to ACXP (12.17%). In terms of maximum drawdown, NVNO dropped -99.81% vs ACXP's -99.14%.

Which has better risk-adjusted returns?

ACXP currently has the higher Sharpe Ratio (-0.46 vs -0.78), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.