MIRM vs. KRYS

Last updated Jun 23, 2026

MIRM (Mirum Pharmaceuticals, Inc.) and KRYS (Krystal Biotech, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, MIRM returned 43.73%/yr vs 39.02%/yr for KRYS. At a 0.36 correlation, their price movements are largely independent.

Performance

MIRM vs. KRYS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Mirum Pharmaceuticals, Inc. (MIRM) and Krystal Biotech, Inc. (KRYS). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, MIRM achieves a 36.43% return, which is significantly lower than KRYS's 39.30% return.

MIRM

• 1D: 0.60%
• 1M: 9.28%
• YTD: 36.43%
• 6M: 32.93%
• 1Y: 114.08%
• 3Y*: 57.95%
• 5Y*: 43.73%
• 10Y*: —

KRYS

• 1D: -1.33%
• 1M: 14.69%
• YTD: 39.30%
• 6M: 37.59%
• 1Y: 159.27%
• 3Y*: 42.18%
• 5Y*: 39.02%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

MIRM vs. KRYS - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
MIRM Mirum Pharmaceuticals, Inc.	36.43%	91.03%	40.07%	51.38%	22.26%	-8.65%	-28.79%	88.62%
KRYS Krystal Biotech, Inc.	39.30%	57.37%	26.28%	56.60%	13.25%	16.58%	8.34%	13.93%

Correlation

The correlation between MIRM and KRYS is 0.34, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.34
Correlation (3Y) Calculated over the trailing 3-year period	0.41
Correlation (5Y) Calculated over the trailing 5-year period	0.40
Correlation (All Time) Calculated using the full available price history since Jul 18, 2019	0.36

Fundamentals

Market Cap MIRM : $6.34B KRYS : $10.48B
EPS MIRM : -$14.81 KRYS : $7.50
PS Ratio MIRM : 14.19 KRYS : 24.70
PB Ratio MIRM : 26.15 KRYS : 8.21
Total Revenue (TTM) MIRM : $409.73M KRYS : $417.30M
Gross Profit (TTM) MIRM : -$422.68M KRYS : $387.24M
EBITDA (TTM) MIRM : -$771.51M KRYS : $185.45M

Return for Risk

MIRM vs. KRYS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MIRM

MIRM Risk / Return Rank: 91
MIRM Sharpe Ratio Rank: 93
MIRM Sortino Ratio Rank: 89
MIRM Omega Ratio Rank: 90
MIRM Calmar Ratio Rank: 93
MIRM Martin Ratio Rank: 91

KRYS

KRYS Risk / Return Rank: 97
KRYS Sharpe Ratio Rank: 98
KRYS Sortino Ratio Rank: 96
KRYS Omega Ratio Rank: 96
KRYS Calmar Ratio Rank: 98
KRYS Martin Ratio Rank: 97

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MIRM vs. KRYS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Mirum Pharmaceuticals, Inc. (MIRM) and Krystal Biotech, Inc. (KRYS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	MIRM	KRYS	Difference
Sharpe ratio: Return per unit of total volatility	2.56	4.10	-1.53
Sortino ratio: Return per unit of downside risk	2.99	4.13	-1.14
Omega ratio: Gain probability vs. loss probability	1.42	1.57	-0.15
Calmar ratio: Return relative to maximum drawdown	5.58	10.05	-4.47
Martin ratio: Return relative to average drawdown	12.76	26.20	-13.45

MIRM vs. KRYS - Sharpe Ratio Comparison

The current MIRM Sharpe Ratio is 2.56, which is lower than the KRYS Sharpe Ratio of 4.10. The chart below compares the historical Sharpe Ratios of MIRM and KRYS, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

MIRM vs. KRYS - Drawdown Comparison

The maximum MIRM drawdown since its inception was -63.78%, which is greater than KRYS's maximum drawdown of -53.42%. Use the drawdown chart below to compare losses from any high point for MIRM and KRYS.

Drawdown Indicators

	MIRM	KRYS	Difference
Max Drawdown Largest peak-to-trough decline	-63.78%	-53.42%	-10.36%
Max Drawdown (1Y) Largest decline over 1 year	-20.55%	-15.94%	-4.61%
Max Drawdown (3Y) Largest decline over 3 years	-32.52%	-42.26%	+9.74%
Max Drawdown (5Y) Largest decline over 5 years	-40.25%	-44.55%	+4.30%
Current Drawdown Current decline from peak	-3.25%	-1.33%	-1.92%
Average Drawdown Average peak-to-trough decline	-20.19%	-16.13%	-4.06%
Ulcer Index Depth and duration of drawdowns from previous peaks	8.98%	6.10%	+2.88%

Volatility

MIRM vs. KRYS - Volatility Comparison

Mirum Pharmaceuticals, Inc. (MIRM) has a higher volatility of 12.12% compared to Krystal Biotech, Inc. (KRYS) at 9.71%. This indicates that MIRM's price experiences larger fluctuations and is considered to be riskier than KRYS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MIRM	KRYS	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.12%	9.71%	+2.41%
Volatility (6M) Calculated over the trailing 6-month period	36.23%	27.40%	+8.83%
Volatility (1Y) Calculated over the trailing 1-year period	44.85%	39.18%	+5.67%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	51.65%	76.47%	-24.82%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	73.91%	74.06%	-0.15%

Dividends

MIRM vs. KRYS - Dividend Comparison

Neither MIRM nor KRYS has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both MIRM and KRYS in my portfolio?

MIRM and KRYS have a correlation of 0.34, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, MIRM or KRYS?

MIRM has higher volatility (12.12%) compared to KRYS (9.71%). In terms of maximum drawdown, MIRM dropped -63.78% vs KRYS's -53.42%.

Which has better risk-adjusted returns?

KRYS currently has the higher Sharpe Ratio (4.10 vs 2.56), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.