MIRM vs. TGTX

Last updated Jun 4, 2026

MIRM (Mirum Pharmaceuticals, Inc.) and TGTX (TG Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, MIRM returned 40.32%/yr vs 2.66%/yr for TGTX. At a 0.27 correlation, their price movements are largely independent.

Performance

MIRM vs. TGTX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Mirum Pharmaceuticals, Inc. (MIRM) and TG Therapeutics, Inc. (TGTX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, MIRM achieves a 16.26% return, which is significantly lower than TGTX's 34.55% return.

MIRM

• 1D: -0.36%
• 1M: -13.19%
• YTD: 16.26%
• 6M: 29.36%
• 1Y: 102.77%
• 3Y*: 51.65%
• 5Y*: 40.32%
• 10Y*: —

TGTX

• 1D: 9.47%
• 1M: 12.34%
• YTD: 34.55%
• 6M: 26.89%
• 1Y: 10.16%
• 3Y*: 14.73%
• 5Y*: 2.66%
• 10Y*: 17.63%

*Multi-year figures are annualized to reflect compound growth (CAGR)

MIRM vs. TGTX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
MIRM Mirum Pharmaceuticals, Inc.	16.26%	91.03%	40.07%	51.38%	22.26%	-8.65%	-28.79%	85.62%
TGTX TG Therapeutics, Inc.	34.55%	-0.96%	76.23%	44.38%	-37.74%	-63.48%	368.65%	39.27%

Correlation

The correlation between MIRM and TGTX is 0.28, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.28
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (5Y) Calculated over the trailing 5-year period	0.30
Correlation (All Time) Calculated using the full available price history since Jul 19, 2019	0.27

Fundamentals

Market Cap MIRM : $5.40B TGTX : $6.42B
EPS MIRM : -$14.81 TGTX : $2.87
PS Ratio MIRM : 12.09 TGTX : 9.21
PB Ratio MIRM : 22.29 TGTX : 11.01
Total Revenue (TTM) MIRM : $409.73M TGTX : $700.35M
Gross Profit (TTM) MIRM : -$422.68M TGTX : $581.54M
EBITDA (TTM) MIRM : -$771.51M TGTX : $156.88M

Return for Risk

MIRM vs. TGTX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MIRM

MIRM Risk / Return Rank: 89
MIRM Sharpe Ratio Rank: 91
MIRM Sortino Ratio Rank: 86
MIRM Omega Ratio Rank: 87
MIRM Calmar Ratio Rank: 91
MIRM Martin Ratio Rank: 90

TGTX

TGTX Risk / Return Rank: 46
TGTX Sharpe Ratio Rank: 48
TGTX Sortino Ratio Rank: 45
TGTX Omega Ratio Rank: 45
TGTX Calmar Ratio Rank: 47
TGTX Martin Ratio Rank: 46

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MIRM vs. TGTX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Mirum Pharmaceuticals, Inc. (MIRM) and TG Therapeutics, Inc. (TGTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	MIRM	TGTX	Difference
Sharpe ratio: Return per unit of total volatility	2.32	0.22	+2.10
Sortino ratio: Return per unit of downside risk	2.79	0.67	+2.12
Omega ratio: Gain probability vs. loss probability	1.39	1.08	+0.31
Calmar ratio: Return relative to maximum drawdown	5.03	0.30	+4.73
Martin ratio: Return relative to average drawdown	12.01	0.52	+11.49
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

MIRM vs. TGTX - Sharpe Ratio Comparison

The current MIRM Sharpe Ratio is 2.32, which is higher than the TGTX Sharpe Ratio of 0.22. The chart below compares the historical Sharpe Ratios of MIRM and TGTX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	MIRM	TGTX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.32	0.22	+2.10
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.79	0.03	+0.76
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.20	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.44	-0.05	+0.49

Drawdowns

MIRM vs. TGTX - Drawdown Comparison

The maximum MIRM drawdown since its inception was -63.78%, smaller than the maximum TGTX drawdown of -99.52%. Use the drawdown chart below to compare losses from any high point for MIRM and TGTX.

Drawdown Indicators

	MIRM	TGTX	Difference
Max Drawdown Largest peak-to-trough decline	-63.78%	-99.52%	+35.74%
Max Drawdown (1Y) Largest decline over 1 year	-20.55%	-34.12%	+13.57%
Max Drawdown (3Y) Largest decline over 3 years	-32.52%	-76.95%	+44.43%
Max Drawdown (5Y) Largest decline over 5 years	-40.25%	-90.75%	+50.50%
Max Drawdown (10Y) Largest decline over 10 years	—	-93.19%	—
Current Drawdown Current decline from peak	-17.56%	-82.82%	+65.26%
Average Drawdown Average peak-to-trough decline	-20.27%	-91.47%	+71.20%
Ulcer Index Depth and duration of drawdowns from previous peaks	8.59%	19.60%	-11.01%

Volatility

MIRM vs. TGTX - Volatility Comparison

The current volatility for Mirum Pharmaceuticals, Inc. (MIRM) is 17.03%, while TG Therapeutics, Inc. (TGTX) has a volatility of 19.58%. This indicates that MIRM experiences smaller price fluctuations and is considered to be less risky than TGTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MIRM	TGTX	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.03%	19.58%	-2.55%
Volatility (6M) Calculated over the trailing 6-month period	36.43%	33.27%	+3.16%
Volatility (1Y) Calculated over the trailing 1-year period	44.53%	46.62%	-2.09%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	51.62%	87.72%	-36.10%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	74.12%	86.87%	-12.75%

Dividends

MIRM vs. TGTX - Dividend Comparison

Neither MIRM nor TGTX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both MIRM and TGTX in my portfolio?

MIRM and TGTX have a correlation of 0.28, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, MIRM or TGTX?

TGTX has higher volatility (19.58%) compared to MIRM (17.03%). In terms of maximum drawdown, MIRM dropped -63.78% vs TGTX's -99.52%.

Which has better risk-adjusted returns?

MIRM currently has the higher Sharpe Ratio (2.32 vs 0.22), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.