MDAI vs. EXEL

Last updated Apr 1, 2026

Compare and contrast key facts about Spectral AI Inc. (MDAI) and Exelixis, Inc. (EXEL).

Performance

MDAI vs. EXEL - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Spectral AI Inc. (MDAI) and Exelixis, Inc. (EXEL). The values are adjusted to include any dividend payments, if applicable.

MDAI vs. EXEL - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
MDAI Spectral AI Inc.	3.52%	-49.82%	15.04%	-75.64%	2.96%	1.13%
EXEL Exelixis, Inc.	-2.14%	31.62%	38.81%	49.56%	-12.25%	-21.65%

Fundamentals

Market Cap MDAI : $44.68M EXEL : $12.09B
EPS MDAI : -$0.29 EXEL : $2.76
PS Ratio MDAI : 2.07 EXEL : 5.24
Total Revenue (TTM) MDAI : $19.41M EXEL : $2.32B
Gross Profit (TTM) MDAI : $8.61M EXEL : $2.24B
EBITDA (TTM) MDAI : -$8.71M EXEL : $934.65M

Returns By Period

In the year-to-date period, MDAI achieves a 3.52% return, which is significantly higher than EXEL's -2.14% return.

MDAI

• 1D: 0.68%
• 1M: 5.00%
• YTD: 3.52%
• 6M: -35.53%
• 1Y: 27.83%
• 3Y*: -47.15%
• 5Y*: —
• 10Y*: —

EXEL

• 1D: 2.24%
• 1M: -2.66%
• YTD: -2.14%
• 6M: 3.85%
• 1Y: 16.17%
• 3Y*: 30.25%
• 5Y*: 13.15%
• 10Y*: 26.62%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

MDAI vs. EXEL — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MDAI

MDAI Risk / Return Rank: 54
MDAI Sharpe Ratio Rank: 55
MDAI Sortino Ratio Rank: 59
MDAI Omega Ratio Rank: 52
MDAI Calmar Ratio Rank: 53
MDAI Martin Ratio Rank: 50

EXEL

EXEL Risk / Return Rank: 56
EXEL Sharpe Ratio Rank: 56
EXEL Sortino Ratio Rank: 52
EXEL Omega Ratio Rank: 54
EXEL Calmar Ratio Rank: 58
EXEL Martin Ratio Rank: 58

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

MDAI vs. EXEL - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Spectral AI Inc. (MDAI) and Exelixis, Inc. (EXEL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	MDAI	EXEL	Difference
Sharpe ratio Return per unit of total volatility	0.38	0.37	+0.01
Sortino ratio Return per unit of downside risk	1.14	0.83	+0.31
Omega ratio Gain probability vs. loss probability	1.12	1.12	0.00
Calmar ratio Return relative to maximum drawdown	0.49	0.67	-0.18
Martin ratio Return relative to average drawdown	0.83	1.55	-0.72
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

MDAI vs. EXEL - Sharpe Ratio Comparison

The current MDAI Sharpe Ratio is 0.38, which is comparable to the EXEL Sharpe Ratio of 0.37. The chart below compares the historical Sharpe Ratios of MDAI and EXEL, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	MDAI	EXEL	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.38	0.37	+0.01
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.36	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.60	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.39	0.07	-0.46

Correlation

The correlation between MDAI and EXEL is 0.08, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

MDAI vs. EXEL - Dividend Comparison

Neither MDAI nor EXEL has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

MDAI vs. EXEL - Drawdown Comparison

The maximum MDAI drawdown since its inception was -93.49%, roughly equal to the maximum EXEL drawdown of -97.38%. Use the drawdown chart below to compare losses from any high point for MDAI and EXEL.

Drawdown Indicators

	MDAI	EXEL	Difference
Max Drawdown Largest peak-to-trough decline	-93.49%	-97.38%	+3.89%
Max Drawdown (1Y) Largest decline over 1 year	-61.78%	-25.34%	-36.44%
Max Drawdown (5Y) Largest decline over 5 years	—	-41.47%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-57.20%	—
Current Drawdown Current decline from peak	-89.81%	-12.91%	-76.90%
Average Drawdown Average peak-to-trough decline	-46.64%	-71.55%	+24.91%
Ulcer Index Depth and duration of drawdowns from previous peaks	36.16%	10.85%	+25.31%

Volatility

MDAI vs. EXEL - Volatility Comparison

Spectral AI Inc. (MDAI) has a higher volatility of 26.41% compared to Exelixis, Inc. (EXEL) at 6.86%. This indicates that MDAI's price experiences larger fluctuations and is considered to be riskier than EXEL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	MDAI	EXEL	Difference
Volatility (1M) Calculated over the trailing 1-month period	26.41%	6.86%	+19.55%
Volatility (6M) Calculated over the trailing 6-month period	51.12%	26.58%	+24.54%
Volatility (1Y) Calculated over the trailing 1-year period	73.97%	43.76%	+30.21%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	80.94%	36.84%	+44.10%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	80.94%	44.88%	+36.06%

Financials

MDAI vs. EXEL - Profitability Comparison

The chart below illustrates the profitability comparison between Spectral AI Inc. and Exelixis, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

MDAI - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Spectral AI Inc. reported a gross profit of 1.53M and revenue of 3.85M. Therefore, the gross margin over that period was 39.8%.

EXEL - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Exelixis, Inc. reported a gross profit of 572.18M and revenue of 598.66M. Therefore, the gross margin over that period was 95.6%.

MDAI - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Spectral AI Inc. reported an operating income of -2.48M and revenue of 3.85M, resulting in an operating margin of -64.5%.

EXEL - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Exelixis, Inc. reported an operating income of 235.22M and revenue of 598.66M, resulting in an operating margin of 39.3%.

MDAI - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Spectral AI Inc. reported a net income of 642.00K and revenue of 3.85M, resulting in a net margin of 16.7%.

EXEL - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Exelixis, Inc. reported a net income of 244.53M and revenue of 598.66M, resulting in a net margin of 40.9%.