IRON vs. AMLX

Last updated Jul 11, 2026

IRON (Disc Medicine Inc.) and AMLX (Amylyx Pharmaceuticals, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, IRON returned 17.02%/yr vs -7.32%/yr for AMLX. At a 0.24 correlation, their price movements are largely independent.

Performance

IRON vs. AMLX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Disc Medicine Inc. (IRON) and Amylyx Pharmaceuticals, Inc. (AMLX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IRON achieves a -3.55% return, which is significantly lower than AMLX's 47.10% return.

IRON

• 1D: -2.98%
• 1M: 12.65%
• 6M: -1.98%
• YTD: -3.55%
• 1Y: 34.58%
• 3Y*: 17.02%
• 5Y*: 5.50%
• 10Y*: —

AMLX

• 1D: -3.32%
• 1M: 21.80%
• 6M: 45.54%
• YTD: 47.10%
• 1Y: 131.38%
• 3Y*: -7.32%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IRON vs. AMLX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
IRON Disc Medicine Inc.	-3.55%	25.25%	9.76%	190.40%	-23.79%
AMLX Amylyx Pharmaceuticals, Inc.	47.10%	219.58%	-74.32%	-60.16%	75.95%

Correlation

The correlation between IRON and AMLX is 0.41, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.41
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (All Time) Calculated using the full available price history since Jan 7, 2022	0.24

The correlation between IRON and AMLX shifts across timeframes, from 0.24 (all time) to 0.41 (1 year), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap IRON : $2.93B AMLX : $1.48B
EPS IRON : -$6.65 AMLX : -$1.51
PB Ratio IRON : 4.28 AMLX : 7.19
Total Revenue (TTM) IRON : $0.00 AMLX : $0.00
Gross Profit (TTM) IRON : -$265.00K AMLX : -$20.10M
EBITDA (TTM) IRON : -$243.47M AMLX : -$150.30M

Return for Risk

IRON vs. AMLX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IRON

IRON Risk / Return Rank: 64
IRON Sharpe Ratio Rank: 66
IRON Sortino Ratio Rank: 63
IRON Omega Ratio Rank: 66
IRON Calmar Ratio Rank: 63
IRON Martin Ratio Rank: 63

AMLX

AMLX Risk / Return Rank: 91
AMLX Sharpe Ratio Rank: 94
AMLX Sortino Ratio Rank: 91
AMLX Omega Ratio Rank: 88
AMLX Calmar Ratio Rank: 93
AMLX Martin Ratio Rank: 90

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IRON vs. AMLX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Disc Medicine Inc. (IRON) and Amylyx Pharmaceuticals, Inc. (AMLX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	IRON	AMLX	Difference
Sharpe ratio: Return per unit of total volatility	0.61	2.31	-1.70
Sortino ratio: Return per unit of downside risk	1.16	2.94	-1.78
Omega ratio: Gain probability vs. loss probability	1.17	1.34	-0.17
Calmar ratio: Return relative to maximum drawdown	0.79	4.62	-3.82
Martin ratio: Return relative to average drawdown	1.64	9.87	-8.23

IRON vs. AMLX - Sharpe Ratio Comparison

The current IRON Sharpe Ratio is 0.61, which is lower than the AMLX Sharpe Ratio of 2.31. The chart below compares the historical Sharpe Ratios of IRON and AMLX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

IRON vs. AMLX - Drawdown Comparison

The maximum IRON drawdown since its inception was -93.22%, roughly equal to the maximum AMLX drawdown of -96.04%. Use the drawdown chart below to compare losses from any high point for IRON and AMLX.

Drawdown Indicators

	IRON	AMLX	Difference
Max Drawdown Largest peak-to-trough decline	-93.22%	-96.04%	+2.82%
Max Drawdown (1Y) Largest decline over 1 year	-40.55%	-30.61%	-9.94%
Max Drawdown (3Y) Largest decline over 3 years	-64.79%	-93.09%	+28.30%
Max Drawdown (5Y) Largest decline over 5 years	-77.02%	—	—
Current Drawdown Current decline from peak	-57.45%	-56.58%	-0.87%
Average Drawdown Average peak-to-trough decline	-66.33%	-59.36%	-6.97%
Ulcer Index Depth and duration of drawdowns from previous peaks	19.61%	14.29%	+5.32%

Volatility

IRON vs. AMLX - Volatility Comparison

The current volatility for Disc Medicine Inc. (IRON) is 9.52%, while Amylyx Pharmaceuticals, Inc. (AMLX) has a volatility of 11.89%. This indicates that IRON experiences smaller price fluctuations and is considered to be less risky than AMLX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IRON	AMLX	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.52%	11.89%	-2.37%
Volatility (6M) Calculated over the trailing 6-month period	42.57%	43.27%	-0.70%
Volatility (1Y) Calculated over the trailing 1-year period	52.77%	61.24%	-8.47%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	69.06%	91.05%	-21.99%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	69.16%	91.05%	-21.89%

Dividends

IRON vs. AMLX - Dividend Comparison

Neither IRON nor AMLX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both IRON and AMLX in my portfolio?

IRON and AMLX have a correlation of 0.41, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IRON or AMLX?

AMLX has higher volatility (11.89%) compared to IRON (9.52%). In terms of maximum drawdown, IRON dropped -93.22% vs AMLX's -96.04%.

Which has better risk-adjusted returns?

AMLX currently has the higher Sharpe Ratio (2.31 vs 0.61), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.