IMVT vs. AXSM

Last updated Jun 23, 2026

IMVT (Immunovant, Inc.) and AXSM (Axsome Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, IMVT returned 28.21%/yr vs 28.89%/yr for AXSM. At a 0.36 correlation, their price movements are largely independent.

Performance

IMVT vs. AXSM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Immunovant, Inc. (IMVT) and Axsome Therapeutics, Inc. (AXSM). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IMVT achieves a 49.88% return, which is significantly higher than AXSM's 35.70% return.

IMVT

• 1D: 7.81%
• 1M: 11.57%
• YTD: 49.88%
• 6M: 38.34%
• 1Y: 141.14%
• 3Y*: 24.11%
• 5Y*: 28.21%
• 10Y*: —

AXSM

• 1D: -1.06%
• 1M: 5.03%
• YTD: 35.70%
• 6M: 60.21%
• 1Y: 146.15%
• 3Y*: 41.16%
• 5Y*: 28.89%
• 10Y*: 42.66%

*Multi-year figures are annualized to reflect compound growth (CAGR)

IMVT vs. AXSM - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
IMVT Immunovant, Inc.	49.88%	2.62%	-41.21%	137.35%	108.33%	-81.55%	191.05%	11.37%
AXSM Axsome Therapeutics, Inc.	35.70%	115.86%	6.31%	3.19%	104.16%	-53.63%	-21.18%	15.40%

Correlation

The correlation between IMVT and AXSM is 0.38, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.38
Correlation (3Y) Calculated over the trailing 3-year period	0.40
Correlation (5Y) Calculated over the trailing 5-year period	0.37
Correlation (All Time) Calculated using the full available price history since Dec 19, 2019	0.36

Fundamentals

Market Cap IMVT : $7.76B AXSM : $12.69B
EPS IMVT : -$2.77 AXSM : -$3.74
PB Ratio IMVT : 9.10 AXSM : 232.46
Total Revenue (TTM) IMVT : $0.00 AXSM : $708.24M
Gross Profit (TTM) IMVT : -$206.00K AXSM : $655.82M
EBITDA (TTM) IMVT : -$527.21M AXSM : -$172.72M

Return for Risk

IMVT vs. AXSM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IMVT

IMVT Risk / Return Rank: 92
IMVT Sharpe Ratio Rank: 91
IMVT Sortino Ratio Rank: 93
IMVT Omega Ratio Rank: 88
IMVT Calmar Ratio Rank: 95
IMVT Martin Ratio Rank: 94

AXSM

AXSM Risk / Return Rank: 97
AXSM Sharpe Ratio Rank: 97
AXSM Sortino Ratio Rank: 98
AXSM Omega Ratio Rank: 96
AXSM Calmar Ratio Rank: 96
AXSM Martin Ratio Rank: 97

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IMVT vs. AXSM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Immunovant, Inc. (IMVT) and Axsome Therapeutics, Inc. (AXSM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	IMVT	AXSM	Difference
Sharpe ratio: Return per unit of total volatility	2.26	3.53	-1.27
Sortino ratio: Return per unit of downside risk	3.53	4.90	-1.37
Omega ratio: Gain probability vs. loss probability	1.39	1.59	-0.20
Calmar ratio: Return relative to maximum drawdown	6.77	7.95	-1.18
Martin ratio: Return relative to average drawdown	15.48	23.42	-7.93

IMVT vs. AXSM - Sharpe Ratio Comparison

The current IMVT Sharpe Ratio is 2.26, which is lower than the AXSM Sharpe Ratio of 3.53. The chart below compares the historical Sharpe Ratios of IMVT and AXSM, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

IMVT vs. AXSM - Drawdown Comparison

The maximum IMVT drawdown since its inception was -93.59%, which is greater than AXSM's maximum drawdown of -86.65%. Use the drawdown chart below to compare losses from any high point for IMVT and AXSM.

Drawdown Indicators

	IMVT	AXSM	Difference
Max Drawdown Largest peak-to-trough decline	-93.59%	-86.65%	-6.94%
Max Drawdown (1Y) Largest decline over 1 year	-20.98%	-18.50%	-2.48%
Max Drawdown (3Y) Largest decline over 3 years	-69.88%	-34.83%	-35.05%
Max Drawdown (5Y) Largest decline over 5 years	-70.38%	-72.91%	+2.53%
Max Drawdown (10Y) Largest decline over 10 years	—	-81.26%	—
Current Drawdown Current decline from peak	-27.72%	-2.87%	-24.85%
Average Drawdown Average peak-to-trough decline	-53.85%	-39.40%	-14.45%
Ulcer Index Depth and duration of drawdowns from previous peaks	9.15%	6.27%	+2.88%

Volatility

IMVT vs. AXSM - Volatility Comparison

Immunovant, Inc. (IMVT) has a higher volatility of 15.09% compared to Axsome Therapeutics, Inc. (AXSM) at 8.92%. This indicates that IMVT's price experiences larger fluctuations and is considered to be riskier than AXSM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IMVT	AXSM	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.09%	8.92%	+6.17%
Volatility (6M) Calculated over the trailing 6-month period	45.21%	33.16%	+12.05%
Volatility (1Y) Calculated over the trailing 1-year period	62.87%	41.74%	+21.13%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	74.94%	70.26%	+4.68%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	78.27%	90.40%	-12.13%

Dividends

IMVT vs. AXSM - Dividend Comparison

Neither IMVT nor AXSM has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both IMVT and AXSM in my portfolio?

IMVT and AXSM have a correlation of 0.38, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IMVT or AXSM?

IMVT has higher volatility (15.09%) compared to AXSM (8.92%). In terms of maximum drawdown, IMVT dropped -93.59% vs AXSM's -86.65%.

Which has better risk-adjusted returns?

AXSM currently has the higher Sharpe Ratio (3.53 vs 2.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.