IBRN vs. USOY

Last updated Jun 3, 2026

IBRN (iShares Neuroscience and Healthcare ETF) and USOY (Defiance Oil Enhanced Options Income ETF) are both exchange-traded funds - IBRN is a Health & Biotech Equities fund tracking the NYSE FactSet Global Neuro Biopharma and MedTech Index, while USOY is a Derivative Income fund actively managed by Defiance. IBRN is passively managed, while USOY is actively managed. Over the past year, IBRN returned 52.57% vs 55.52% for USOY. At a correlation of -0.12, they often move in opposite directions. IBRN charges 0.47%/yr vs 1.22%/yr for USOY.

Performance

IBRN vs. USOY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Neuroscience and Healthcare ETF (IBRN) and Defiance Oil Enhanced Options Income ETF (USOY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IBRN achieves a 4.62% return, which is significantly lower than USOY's 59.86% return.

IBRN

• 1D: -4.52%
• 1M: -1.90%
• YTD: 4.62%
• 6M: 12.73%
• 1Y: 52.57%
• 3Y*: 11.10%
• 5Y*: —
• 10Y*: —

USOY

• 1D: 1.63%
• 1M: -1.93%
• YTD: 59.86%
• 6M: 58.33%
• 1Y: 55.52%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

IBRN vs. USOY - Yearly Performance Comparison

	2026 (YTD)	2025	2024
IBRN iShares Neuroscience and Healthcare ETF	4.62%	28.49%	9.57%
USOY Defiance Oil Enhanced Options Income ETF	59.86%	-7.93%	7.27%

Correlation

The correlation between IBRN and USOY is -0.31, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.31
Correlation (All Time) Calculated using the full available price history since May 13, 2024	-0.13

The correlation between IBRN and USOY shifts across timeframes, from -0.31 (1 year) to -0.12 (all time), reflecting how their relationship changes across market environments.

Return for Risk

IBRN vs. USOY — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IBRN

IBRN Risk / Return Rank: 69
IBRN Sharpe Ratio Rank: 61
IBRN Sortino Ratio Rank: 62
IBRN Omega Ratio Rank: 53
IBRN Calmar Ratio Rank: 92
IBRN Martin Ratio Rank: 79

USOY

USOY Risk / Return Rank: 56
USOY Sharpe Ratio Rank: 53
USOY Sortino Ratio Rank: 45
USOY Omega Ratio Rank: 54
USOY Calmar Ratio Rank: 79
USOY Martin Ratio Rank: 47

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IBRN vs. USOY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Neuroscience and Healthcare ETF (IBRN) and Defiance Oil Enhanced Options Income ETF (USOY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IBRN	USOY	Difference
Sharpe ratio Return per unit of total volatility	2.09	1.83	+0.25
Sortino ratio Return per unit of downside risk	2.94	2.25	+0.69
Omega ratio Gain probability vs. loss probability	1.34	1.34	0.00
Calmar ratio Return relative to maximum drawdown	6.30	4.10	+2.20
Martin ratio Return relative to average drawdown	15.59	7.91	+7.68
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IBRN vs. USOY - Sharpe Ratio Comparison

The current IBRN Sharpe Ratio is 2.09, which is comparable to the USOY Sharpe Ratio of 1.83. The chart below compares the historical Sharpe Ratios of IBRN and USOY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IBRN	USOY	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.09	1.83	+0.25
Sharpe Ratio (All Time) Calculated using the full available price history	0.37	0.96	-0.59

Drawdowns

IBRN vs. USOY - Drawdown Comparison

The maximum IBRN drawdown since its inception was -35.38%, which is greater than USOY's maximum drawdown of -17.46%. Use the drawdown chart below to compare losses from any high point for IBRN and USOY.

Drawdown Indicators

	IBRN	USOY	Difference
Max Drawdown Largest peak-to-trough decline	-35.38%	-17.46%	-17.92%
Max Drawdown (1Y) Largest decline over 1 year	-8.80%	-14.29%	+5.49%
Max Drawdown (3Y) Largest decline over 3 years	-35.38%	—	—
Current Drawdown Current decline from peak	-6.28%	-6.47%	+0.19%
Average Drawdown Average peak-to-trough decline	-9.83%	-6.47%	-3.36%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.56%	7.42%	-3.86%

Volatility

IBRN vs. USOY - Volatility Comparison

The current volatility for iShares Neuroscience and Healthcare ETF (IBRN) is 7.66%, while Defiance Oil Enhanced Options Income ETF (USOY) has a volatility of 11.94%. This indicates that IBRN experiences smaller price fluctuations and is considered to be less risky than USOY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IBRN	USOY	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.66%	11.94%	-4.28%
Volatility (6M) Calculated over the trailing 6-month period	19.29%	27.16%	-7.87%
Volatility (1Y) Calculated over the trailing 1-year period	25.38%	30.46%	-5.08%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.32%	26.14%	-0.82%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.32%	26.14%	-0.82%

IBRN vs. USOY - Expense Ratio Comparison

IBRN has a 0.47% expense ratio, which is lower than USOY's 1.22% expense ratio.

Dividends

IBRN vs. USOY - Dividend Comparison

IBRN's dividend yield for the trailing twelve months is around 0.95%, less than USOY's 54.95% yield.

Position	TTM	2025	2024	2023
IBRN iShares Neuroscience and Healthcare ETF	0.95%	0.99%	0.40%	0.06%
USOY Defiance Oil Enhanced Options Income ETF	54.95%	104.32%	48.60%	0.00%

Frequently Asked Questions

Can I hold both IBRN and USOY in my portfolio?

IBRN and USOY have a correlation of -0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IBRN or USOY?

USOY has higher volatility (11.94%) compared to IBRN (7.66%). In terms of maximum drawdown, IBRN dropped -35.38% vs USOY's -17.46%.

Which ETF is better, IBRN or USOY?

On 1-year performance, USOY leads with 55.52% vs 52.57% for IBRN. On fees, IBRN is cheaper at 0.47% per year. On volatility, IBRN has been the lower-risk option at 7.66%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IBRN or USOY?

Over the 1-year period, USOY has performed better with a 55.52% return vs 52.57%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IBRN or USOY?

IBRN is cheaper with a 0.47% expense ratio, compared with 1.22% for USOY.

Which ETF pays a higher dividend yield, IBRN or USOY?

USOY has the higher dividend yield at 54.95%, compared with 0.95% for IBRN.

What is the main difference between IBRN and USOY?

IBRN is categorized as Health & Biotech Equities, while USOY is Derivative Income. They also come from different issuers: iShares and Defiance. Their fees differ too: 0.47% for IBRN and 1.22% for USOY.

Which has better risk-adjusted returns?

IBRN currently has the higher Sharpe Ratio (2.09 vs 1.83), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.