IBRN vs. IBBQ

Last updated Aug 2, 2026

IBRN (iShares Neuroscience and Healthcare ETF) and IBBQ (Invesco Nasdaq Biotechnology ETF) are both Health & Biotech Equities funds - IBRN tracks the NYSE FactSet Global Neuro Biopharma and MedTech Index while IBBQ tracks the Nasdaq Biotechnology Index. Both are passively managed. Over the past 3 years, IBRN returned 14.57%/yr vs 17.25%/yr for IBBQ. Their correlation of 0.83 means they have usually moved in the same direction. IBRN charges 0.47%/yr vs 0.19%/yr for IBBQ.

Performance

IBRN vs. IBBQ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares Neuroscience and Healthcare ETF (IBRN) and Invesco Nasdaq Biotechnology ETF (IBBQ). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

The year-to-date returns for both investments are quite close, with IBRN having a 13.26% return and IBBQ slightly higher at 13.32%.

IBRN

• 1D: -3.24%
• 1M: -6.28%
• 6M: 12.31%
• YTD: 13.26%
• 1Y: 59.23%
• 3Y*: 14.57%
• 5Y*: —
• 10Y*: —
• ALL TIME*: 10.28%

IBBQ

• 1D: -1.84%
• 1M: -4.55%
• 6M: 10.60%
• YTD: 13.32%
• 1Y: 44.71%
• 3Y*: 17.25%
• 5Y*: 5.42%
• 10Y*: —
• ALL TIME*: 5.57%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
IBBQ Invesco Nasdaq Biotechnology ETF	$517.67K	$836.57K	$727.46K
IBRN iShares Neuroscience and Healthcare ETF	$83.61K	$123.63K	$97.37K

IBRN vs. IBBQ - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
IBRN iShares Neuroscience and Healthcare ETF	13.26%	28.49%	-2.78%	0.92%	2.87%
IBBQ Invesco Nasdaq Biotechnology ETF	13.32%	33.32%	-0.63%	4.73%	4.14%

Correlation

The correlation between IBRN and IBBQ is 0.82, meaning they have usually moved in the same direction, including during past declines.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.82
Correlation (3Y) Balances recent behavior with more history.	0.83
Correlation (All Time) Calculated using the full available price history since Aug 26, 2022	0.83

The correlation between IBRN and IBBQ has been stable across timeframes, ranging from 0.82 to 0.83 - a consistent structural relationship.

IBRN vs. IBBQ - Sectors Allocation Comparison

Sectors	IBRN	IBBQ
Healthcare	100.0%	100.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	0.1%
Consumer Defensive	-	0.2%
Energy	-	-
Financial Services	-	0.1%
Industrials	-	0.0%
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

IBRN vs. IBBQ — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

IBRN

IBRN Risk / Return Rank: 91
IBRN Sharpe Ratio Rank: 91
IBRN Sortino Ratio Rank: 89
IBRN Omega Ratio Rank: 84
IBRN Calmar Ratio Rank: 96
IBRN Martin Ratio Rank: 93

IBBQ

IBBQ Risk / Return Rank: 91
IBBQ Sharpe Ratio Rank: 91
IBBQ Sortino Ratio Rank: 90
IBBQ Omega Ratio Rank: 85
IBBQ Calmar Ratio Rank: 95
IBBQ Martin Ratio Rank: 92

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

IBRN vs. IBBQ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares Neuroscience and Healthcare ETF (IBRN) and Invesco Nasdaq Biotechnology ETF (IBBQ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	IBRN	IBBQ	Difference
Sharpe ratio: Return per unit of total volatility	2.29	2.27	+0.02
Sortino ratio: Return per unit of downside risk	3.10	3.12	-0.03
Omega ratio: Gain probability vs. loss probability	1.36	1.37	-0.01
Calmar ratio: Return relative to maximum drawdown	6.42	5.49	+0.93
Martin ratio: Return relative to average drawdown	16.74	15.87	+0.87

IBRN vs. IBBQ - Sharpe Ratio Comparison

The current IBRN Sharpe Ratio is 2.29, which is comparable to the IBBQ Sharpe Ratio of 2.27. The chart below compares the historical Sharpe Ratios of IBRN and IBBQ, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

IBRN vs. IBBQ - Drawdown Comparison

The maximum IBRN drawdown since its inception was -35.38%, smaller than the maximum IBBQ drawdown of -37.94%. Use the drawdown chart below to compare losses from any high point for IBRN and IBBQ.

Drawdown Indicators

	IBRN	IBBQ	Difference
Max Drawdown Largest peak-to-trough decline	-35.38%	-37.94%	+2.56%
Max Drawdown (1Y) Largest decline over 1 year	-9.15%	-8.34%	-0.81%
Max Drawdown (3Y) Largest decline over 3 years	-35.38%	-23.66%	-11.72%
Max Drawdown (5Y) Largest decline over 5 years	—	-37.94%	—
Current Drawdown Current decline from peak	-9.15%	-6.14%	-3.01%
Average Drawdown Average peak-to-trough decline	-9.59%	-16.38%	+6.79%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.50%	2.88%	+0.62%

Volatility

IBRN vs. IBBQ - Volatility Comparison

iShares Neuroscience and Healthcare ETF (IBRN) has a higher volatility of 7.68% compared to Invesco Nasdaq Biotechnology ETF (IBBQ) at 6.31%. This indicates that IBRN's price experiences larger fluctuations and is considered to be riskier than IBBQ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IBRN	IBBQ	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.68%	6.31%	+1.37%
Volatility (6M) Calculated over the trailing 6-month period	19.64%	15.72%	+3.92%
Volatility (1Y) Calculated over the trailing 1-year period	25.61%	20.18%	+5.43%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	25.34%	21.98%	+3.36%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.34%	21.85%	+3.49%

IBRN vs. IBBQ - Expense Ratio Comparison

IBRN has a 0.47% expense ratio, which is higher than IBBQ's 0.19% expense ratio.

Dividends

IBRN vs. IBBQ - Dividend Comparison

IBRN's dividend yield for the trailing twelve months is around 0.87%, more than IBBQ's 0.80% yield.

Position	TTM	2025	2024	2023	2022	2021
IBBQ Invesco Nasdaq Biotechnology ETF	0.80%	0.90%	1.14%	0.81%	0.76%	0.63%
IBRN iShares Neuroscience and Healthcare ETF	0.87%	0.99%	0.40%	0.06%	0.00%	0.00%

Frequently Asked Questions

Can I hold both IBRN and IBBQ in my portfolio?

IBRN and IBBQ have a correlation of 0.82, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IBRN or IBBQ?

IBRN has higher volatility (7.68%) compared to IBBQ (6.31%). In terms of maximum drawdown, IBRN dropped -35.38% vs IBBQ's -37.94%.

Which ETF is better, IBRN or IBBQ?

On 3-year performance, IBBQ leads with 17.25% vs 14.57% for IBRN. On fees, IBBQ is cheaper at 0.19% per year. On volatility, IBBQ has been the lower-risk option at 6.31%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IBRN or IBBQ?

Over the 3-year period, IBBQ has performed better with a 17.25% return vs 14.57%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IBRN or IBBQ?

IBBQ is cheaper with a 0.19% expense ratio, compared with 0.47% for IBRN.

Which ETF pays a higher dividend yield, IBRN or IBBQ?

IBRN has the higher dividend yield at 0.87%, compared with 0.80% for IBBQ.

What is the main difference between IBRN and IBBQ?

IBRN tracks NYSE FactSet Global Neuro Biopharma and MedTech Index, while IBBQ tracks Nasdaq Biotechnology Index. They also come from different issuers: iShares and Invesco. Their fees differ too: 0.47% for IBRN and 0.19% for IBBQ.

Which has better risk-adjusted returns?

IBRN currently has the higher Sharpe Ratio (2.29 vs 2.27), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.