GNOG.L vs. BIOT.L

Last updated Jul 16, 2026

GNOG.L (Global X Genomics & Biotechnology UCITS ETF) and BIOT.L (L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF) are both Health & Biotech Equities funds - GNOG.L tracks the MSCI World/Health Care NR USD while BIOT.L tracks the Solactive Pharma Breakthrough Value Index Net Total Return. Both are passively managed. Over the past 3 years, GNOG.L returned 3.96%/yr vs 8.83%/yr for BIOT.L. A 0.70 correlation means they provide meaningful diversification when combined. GNOG.L charges 0.50%/yr vs 0.49%/yr for BIOT.L.

Performance

GNOG.L vs. BIOT.L - Performance Comparison

The chart below illustrates the hypothetical performance of a £10,000 investment in Global X Genomics & Biotechnology UCITS ETF (GNOG.L) and L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF (BIOT.L). The values are adjusted to include any dividend payments, if applicable.

Different Trading Currencies

GNOG.L is traded in GBP, while BIOT.L is traded in USD. To make them comparable, the BIOT.L values have been converted to GBP using the latest available exchange rates.

Returns By Period

In the year-to-date period, GNOG.L achieves a 21.62% return, which is significantly higher than BIOT.L's 7.49% return.

GNOG.L

• 1D: -0.67%
• 1M: 11.16%
• 6M: 15.16%
• YTD: 21.62%
• 1Y: 61.62%
• 3Y*: 3.96%
• 5Y*: —
• 10Y*: —

BIOT.L

• 1D: 0.00%
• 1M: 6.51%
• 6M: 6.57%
• YTD: 7.49%
• 1Y: 31.98%
• 3Y*: 8.83%
• 5Y*: 3.12%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

GNOG.L vs. BIOT.L - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
GNOG.L Global X Genomics & Biotechnology UCITS ETF	21.62%	12.01%	-17.02%	-11.28%	-29.74%	-32.17%
BIOT.L L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF	7.49%	26.75%	-3.66%	-13.81%	2.48%	-2.81%

Correlation

The correlation between GNOG.L and BIOT.L is 0.71, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.71
Correlation (3Y) Calculated over the trailing 3-year period	0.69
Correlation (All Time) Calculated using the full available price history since Nov 2, 2021	0.70

The correlation between GNOG.L and BIOT.L has been stable across timeframes, ranging from 0.69 to 0.71 - a consistent structural relationship.

Return for Risk

GNOG.L vs. BIOT.L — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GNOG.L

GNOG.L Risk / Return Rank: 78
GNOG.L Sharpe Ratio Rank: 85
GNOG.L Sortino Ratio Rank: 82
GNOG.L Omega Ratio Rank: 75
GNOG.L Calmar Ratio Rank: 83
GNOG.L Martin Ratio Rank: 63

BIOT.L

BIOT.L Risk / Return Rank: 67
BIOT.L Sharpe Ratio Rank: 63
BIOT.L Sortino Ratio Rank: 64
BIOT.L Omega Ratio Rank: 55
BIOT.L Calmar Ratio Rank: 83
BIOT.L Martin Ratio Rank: 70

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GNOG.L vs. BIOT.L - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Global X Genomics & Biotechnology UCITS ETF (GNOG.L) and L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF (BIOT.L). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	GNOG.L	BIOT.L	Difference
Sharpe ratio: Return per unit of total volatility	2.19	1.58	+0.62
Sortino ratio: Return per unit of downside risk	2.94	2.26	+0.69
Omega ratio: Gain probability vs. loss probability	1.35	1.27	+0.08
Calmar ratio: Return relative to maximum drawdown	3.58	3.15	+0.43
Martin ratio: Return relative to average drawdown	9.03	9.02	+0.01

GNOG.L vs. BIOT.L - Sharpe Ratio Comparison

The current GNOG.L Sharpe Ratio is 2.19, which is higher than the BIOT.L Sharpe Ratio of 1.58. The chart below compares the historical Sharpe Ratios of GNOG.L and BIOT.L, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

GNOG.L vs. BIOT.L - Drawdown Comparison

The maximum GNOG.L drawdown since its inception was -75.79%, which is greater than BIOT.L's maximum drawdown of -30.68%. Use the drawdown chart below to compare losses from any high point for GNOG.L and BIOT.L.

Drawdown Indicators

	GNOG.L	BIOT.L	Difference
Max Drawdown Largest peak-to-trough decline	-75.79%	-30.68%	-45.11%
Max Drawdown (1Y) Largest decline over 1 year	-17.11%	-10.21%	-6.90%
Max Drawdown (3Y) Largest decline over 3 years	-45.79%	-19.56%	-26.23%
Max Drawdown (5Y) Largest decline over 5 years	—	-30.68%	—
Current Drawdown Current decline from peak	-53.05%	-7.02%	-46.03%
Average Drawdown Average peak-to-trough decline	-58.21%	-10.48%	-47.73%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.81%	3.57%	+3.24%

Volatility

GNOG.L vs. BIOT.L - Volatility Comparison

Global X Genomics & Biotechnology UCITS ETF (GNOG.L) has a higher volatility of 8.33% compared to L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF (BIOT.L) at 6.34%. This indicates that GNOG.L's price experiences larger fluctuations and is considered to be riskier than BIOT.L based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GNOG.L	BIOT.L	Difference
Volatility (1M) Calculated over the trailing 1-month period	8.33%	6.34%	+1.99%
Volatility (6M) Calculated over the trailing 6-month period	20.29%	15.32%	+4.97%
Volatility (1Y) Calculated over the trailing 1-year period	28.06%	20.40%	+7.66%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	35.66%	17.99%	+17.67%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	35.66%	19.14%	+16.52%

GNOG.L vs. BIOT.L - Expense Ratio Comparison

GNOG.L has a 0.50% expense ratio, which is higher than BIOT.L's 0.49% expense ratio.

Dividends

GNOG.L vs. BIOT.L - Dividend Comparison

Neither GNOG.L nor BIOT.L has paid dividends to shareholders.

Tickers have no history of dividend payments

Frequently Asked Questions

Can I hold both GNOG.L and BIOT.L in my portfolio?

GNOG.L and BIOT.L have a correlation of 0.71, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, GNOG.L or BIOT.L?

On fees, BIOT.L is cheaper at 0.49% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, GNOG.L or BIOT.L?

BIOT.L is cheaper with a 0.49% expense ratio, compared with 0.50% for GNOG.L.

What is the main difference between GNOG.L and BIOT.L?

GNOG.L tracks MSCI World/Health Care NR USD, while BIOT.L tracks Solactive Pharma Breakthrough Value Index Net Total Return. They also come from different issuers: Global X and L&G. Their fees differ too: 0.50% for GNOG.L and 0.49% for BIOT.L.